Chlorpromazine versus Metoclopramide for Neurogenic Nausea and Vomiting in Incurable Patients with Gastrointestinal Tumors: A Prospective Observational Cohort Study [0.03%]
氯丙嗪与胃复安治疗胃肠肿瘤终末期患者神经源性恶心和呕吐的疗效观察：前瞻性队列研究
Anna Konysheva,Stanislav Myasoyedov
Anna Konysheva
Background: Nausea and vomiting are prevalent symptoms in incurable patients with gastrointestinal (GI) tumors. While standard antiemetic protocols are widely used, evidence supporting mechanism-based treatment selection ...
Hippo-YAP/TAZ Signaling in Hematological Malignancies: Molecular Mechanisms, Pathway Crosstalk and Therapeutic Potential [0.03%]
斑马鱼血管病相关基因yap/taz在血液系统恶性肿瘤中的信号机制、通路互作及治疗潜力研究
Wanfu Jiang,Changling Zhu,Li Xu et al.
Wanfu Jiang et al.
The Hippo signaling pathway represents an evolutionarily conserved regulatory network. It plays a central role in controlling cell proliferation, apoptosis, differentiation, and tissue homeostasis. Increasing evidence indicates that dysregu...
The Interaction of PI3K/AKT/mTOR Pathway with the Tumor Microenvironment: A Dual Engine Driving Breast Cancer Progression and Reshaping Treatment Strategies [0.03%]
PI3K/AKT/mTOR信号通路与肿瘤微环境的相互作用：驱动乳腺癌进展和重塑治疗策略的双引擎
Xi Huang,Chunjun Xia,Xiangyue Jin et al.
Xi Huang et al.
The PI3K/AKT/mTOR signaling pathway, as a core regulatory network for cell growth, proliferation and metabolism, frequently undergoes abnormal activation in breast cancer, becoming a key driver of tumor occurrence and development. In recent...
Xinru Yang,Yi Tang,Genyun Liu et al.
Xinru Yang et al.
Cervical cancer (CC) remains a major gynecological malignancy worldwide, and patients with recurrent, metastatic, or treatment-resistant disease continue to have limited therapeutic options. Human epidermal growth factor receptor 2 (HER2) i...
Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk [0.03%]
结直肠癌进展和骨转移：分子机制、肿瘤微环境及肿瘤-骨骼相互作用
Xiang Qi,Shuai Hao,Yue Sun et al.
Xiang Qi et al.
Colorectal cancer (CRC) ranks as the third most common malignancy globally and represents one of the main causes of cancer-related death. This narrative review provides a comprehensive synthesis of recent advances in the molecular mechanism...
Molecular Response to Treatment of Chronic Myeloid Leukemia at University Teaching Hospital of Kigali, Rwanda: One-Arm Open Label Prospective Observational Study [0.03%]
卢旺达基加利大学教学医院慢性粒细胞性白血病治疗的分子反应：单臂、开放性标签前瞻性观察研究
Gilbert Uwizeyimana,Florence Masaisa,Belson Rugwizangoga et al.
Gilbert Uwizeyimana et al.
Background: Chronic myeloid leukemia (CML) is among most common chronic hematological neoplasms marked by proliferation of granulocytes. Since 2001, the introduction of tyrosine kinase inhibitors (TKI), especially imatini...
Common Bile Duct Diameter in Bladder Urothelial Carcinoma: A Case-Control Study [0.03%]
胆汁总管直径与膀胱尿路上皮癌病例对照研究
Adeleh Dadkhah,Masoome Zolfaghari,Seyed Morteza Bagheri et al.
Adeleh Dadkhah et al.
Background: Although sporadic case reports have suggested an association between bladder urothelial carcinoma and common bile duct (CBD) dilation, no comprehensive study has investigated this association. This study aimed...
Combining Serum PVT1 Exon 4A and Exon 9 with Serum Prostate-Specific Antigen Shows Potential for Improving Identification and Risk Stratification of Prostate Cancer [0.03%]
血清PVT1外显子4A和外显子9与血清前列腺特异性抗原联合检测可望提高前列腺癌的识别及风险分层能力
Emmanuel Asante-Asamani,Rachel E Bonacci,Tinovimba Hove et al.
Emmanuel Asante-Asamani et al.
Purpose: Prostate-specific antigen (PSA), a common screening tool for prostate cancer (PCa), has a high false-positive rate and is largely suboptimal. PSA is also weakly validated in men of African ancestry (moAA), who di...
Jianpi Rougan Method in Support of Lenvatinib Therapy: A Real-World Study on Maintaining Relative Dose Intensity and Mitigating Toxicity-Driven Discontinuation in Intermediate-to-Advanced HCC [0.03%]
健脾柔肝法助力仑伐替尼治疗：一项真实世界研究，维持相对剂量强度及减毒减停的疗效观察（中英文摘要）
Tianbin Zhang,Peng Kuang
Tianbin Zhang
Purpose: To investigate the effects of Jianpi Rougan method on lenvatinib (LEN) relative dose intensity (RDI), toxicity-related treatment discontinuation, and treatment tolerability in intermediate-to-advanced hepatocellu...
Baseline Nutritional Indices as Prognostic Indicators in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma Treated with the PD-L1 Inhibitor KL-A167: A Secondary Analysis of the KL-A167 Trial [0.03%]
基线营养指数作为接受PD-L1抑制剂KL-A167治疗的复发或转移性鼻咽癌患者预后指标的探索：一项来自KL-A167研究的事后分析
Huilin Li,Zheran Liu,Jiacheng Li et al.
Huilin Li et al.
Background: Nutritional status is a recognized prognostic factor in oncology. However, its impact on patients with recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) treated with the PD-L1 inhibitor KL-A167 remain...