Protocadherin 1 (PCDH1) Promotes Pancreatic Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition (EMT) Progression Through the NF-κB Pathway [0.03%]
原癌基因PCDH1通过NF-κB通路调节上皮间质转化促进胰腺癌转移
JianXin Lv,Jie Lou,Shaoqing Ding et al.
JianXin Lv et al.
Objective: This study investigates the role of the protocadherin-1 (PCDH1) gene in pancreatic cancer metastasis, focusing on its influence on the epithelial-mesenchymal transition (EMT) process and the NF-κB signaling pa...
Synergistic Inhibition of Angiogenesis and Tumor Progression by CD73 Inhibitor and Menstrual Blood Stem Cell-Derived Exosomes via miR-422a Upregulation in HER2-Positive Breast Cancer [0.03%]
CD73抑制剂和月經血源性干细胞衍生的外泌体通过上调miR-422a在HER2阳性乳腺癌中协同抑制血管生成和肿瘤进展
Narges Jafarbeik Iravani,Keivan Majidzadeh-A,Samaneh Arab et al.
Narges Jafarbeik Iravani et al.
Objective: HER2-positive breast cancer (HER2+ BC) remains an aggressive subtype with limited treatment efficacy due to therapeutic resistance and systemic toxicities. CD73, an ectoenzyme producing extracellular adenosine,...
Preoperative Prognostic Factors of Colorectal Cancer in Patients from Central China: A Retrospective Observational Study [0.03%]
中部中国结直肠癌患者术前预后因素的回顾性观察研究
Qilin Fan,Min Jin,Jun Fan et al.
Qilin Fan et al.
Purpose: This study aimed to investigate the clinicopathological characteristics and identify prognostic factors influencing overall survival (OS) in colorectal cancer (CRC) patients from central China. ...
Apolipoprotein E (APOE) Promotes Cell Proliferation and Invasion in Glioma via the PI3K/AKT Signaling Pathway [0.03%]
载脂蛋白E(APOE)通过PI3K/AKT信号通路促进胶质瘤细胞增殖和侵袭
Mengdi Xia,Ke Chen,Weiwei Chen et al.
Mengdi Xia et al.
Background: Glioma presents significant therapeutic challenges due to its marked heterogeneity and resistance to conventional treatments. Apolipoprotein E (APOE), a glycoprotein involved in lipid metabolism, has been repo...
Burden of Care: Stress, Anxiety, Depression, and Quality of Life in Cancer Caregivers in Kuwait: A Cross-Sectional Study [0.03%]
护理负担：科威特癌症照顾者的压力、焦虑、抑郁和生活质量状况：一项横断面研究
Hamad Alhamad,Ahmad Alenezi,Haya Shabakoh et al.
Hamad Alhamad et al.
Introduction: Cancer care frequently relies on unpaid family caregivers who face substantial psychological strain that may diminish their quality of life (QoL). Local evidence from Kuwait is limited. In Kuwait, where fami...
Development and Validation of a Traditional Chinese Medicine Constitution-Based Risk Score for Advanced Colorectal Neoplasia in Asymptomatic Chinese Adults [0.03%]
基于中医药体质的无症状成人进展期结直肠病变风险评分的制订及验证
Chenxi Huang,Yue Hou,Qing-Hua Liu et al.
Chenxi Huang et al.
Objective: The objective of this study was to develop and validate an innovative risk-stratification tool that integrates Traditional Chinese Medicine (TCM) constitution with clinical factors to enhance colorectal cancer ...
Taxanes Versus Pemetrexed After Osimertinib Resistance in EGFR-Mutated NSCLC: A Retrospective Cohort with Two-Model In Vitro Validation [0.03%]
表皮生长因子受体突变非小细胞肺癌奥希替尼耐药后紫杉烷类与培美曲塞：含体外两种模型验证的回顾性队列研究
Ning Yang,Ning Wan,Ya Guo et al.
Ning Yang et al.
Purpose: To evaluate whether chemotherapy backbone selection influences outcomes in epidermal growth factor receptor (EGFR)‑mutated non-small cell lung cancer (NSCLC) after acquired resistance to osimertinib, addressing ...
Clinicopathological Spectrum and Survival in Esophageal Neuroendocrine Carcinoma and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms: A 74-Patient Cohort [0.03%]
食管神经内分泌癌和混合型神经内分泌-非神经内分泌肿瘤的临床病理谱及生存情况：一项74例患者的队列研究
Lingjuan Zhang,Shengli Zhou,Zhiquan Gong et al.
Lingjuan Zhang et al.
Background: Primary esophageal neuroendocrine carcinoma (NEC) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies with a poor prognosis. Data on clinicopathological features and survival o...
Identification of BRCA1-Associated RING Domain 1 Mutation as a Novel Indicator for Constructing a Prognostic Nomogram in Multiple Myeloma: A Retrospective Single-Center Study [0.03%]
BRCA1相关RING结构域1突变作为构建多发性骨髓瘤预后 nomogram的新型指示标志物的鉴定：一项回顾性单中心研究
Ling Lin,Xin Xu,Tong Yang et al.
Ling Lin et al.
Background: This study aims to investigate the prognostic value of BARD1 (BRCA1-associated RING domain 1) in newly diagnosed multiple myeloma (NDMM), which has not been well defined previously. ...
Improving Non-Invasive Prediction of Thyroid Nodule Malignancy: A Machine Learning-Based Clinical Approach [0.03%]
基于机器学习的改进非侵入预测甲状腺结节恶性的临床方法
Maja Reiner,Hanna Drobińska,Michał Miciak et al.
Maja Reiner et al.
Background: Thyroid cancer (TC) is the most commonly diagnosed endocrine malignancy, with rising global incidence. Current diagnostic techniques, including ultrasound and fine-needle aspiration biopsy (FNAB), often yield ...