Adult human mesenchymal stromal cells and the treatment of graft versus host disease [0.03%]
人源成人脉络膜前体细胞与移植物抗宿主病的治疗
Richard P Herrmann,Marian J Sturm
Richard P Herrmann
Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor human leucocyte antigen (HLA) mismatch and is normally treated with corticosteroid and other immun...
Dheeraj Kalladka,Keith W Muir
Dheeraj Kalladka
Stroke affects one in every six people worldwide, and is the leading cause of adult disability. Some spontaneous recovery is usual but of limited extent, and the mechanisms of late recovery are not completely understood. Endogenous neurogen...
Sophia Kelaini,Amy Cochrane,Andriana Margariti
Sophia Kelaini
The procedure of using mature, fully differentiated cells and inducing them toward other cell types while bypassing an intermediate pluripotent state is termed direct reprogramming. Avoiding the pluripotent stage during cellular conversions...
Patrick Orth,Ana Rey-Rico,Jagadeesh K Venkatesan et al.
Patrick Orth et al.
Protocols based on the delivery of stem cells are currently applied in patients, showing encouraging results for the treatment of articular cartilage lesions (focal defects, osteoarthritis). Yet, restoration of a fully functional cartilage ...
Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models [0.03%]
神经疾病模型中的人类个体化诱导多能干细胞与非人灵长类动物模型的重要性
Zhifang Qiu,Steven L Farnsworth,Anuja Mishra et al.
Zhifang Qiu et al.
The development of the technology for derivation of induced pluripotent stem (iPS) cells from human patients and animal models has opened up new pathways to the better understanding of many human diseases, and has created new opportunities ...
Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives [0.03%]
干细胞时代的细胞治疗智慧：我们的观点
Senthilkumar Preethy,Sudhakar John,Jegatheesan Saravana Ganesh et al.
Senthilkumar Preethy et al.
Among the various strategies providing a cure for illness, cell-based therapies have caught the attention of the world with the advent of the "stem cell" era. Our inherent understanding indicates that stem cells have been in existence since...
Tania Fuentes,Mary Kearns-Jonker
Tania Fuentes
Stem cell-based therapies hold promise for regenerating the myocardium after injury. Recent data obtained from phase I clinical trials using endogenous cardiovascular progenitors isolated directly from the heart suggest that cell-based trea...
Understanding the application of stem cell therapy in cardiovascular diseases [0.03%]
干细胞治疗在心血管疾病中的应用理解
Rakesh K Sharma,Donald J Voelker,Roma Sharma et al.
Rakesh K Sharma et al.
Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of r...
Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data [0.03%]
干细胞在严重脊髓损伤中潜在作用：当前观点和临床数据
Syed Ab Paspala,Sandeep K Vishwakarma,Tenneti Vrk Murthy et al.
Syed Ab Paspala et al.
Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the potential to restore function and ease the associated social and economic burden in the years ahead. Various sources of stem cells hav...
C Botti,C Maione,A Coppola et al.
C Botti et al.
Inadequate blood supply to tissues caused by obstruction of arterioles and/or capillaries results in ischemic injuries - these injuries can range from mild (eg, leg ischemia) to severe conditions (eg, myocardial infarction, stroke). Surgica...