Patient-Derived Organoids for Guiding Neoadjuvant Chemotherapy in Bilateral Primary Breast Cancer: A Case Report [0.03%]
患者源类器官用于指导双侧原发乳腺癌新辅助化疗一例报告
Meng Cao,Rong Wang,Xiaohan Cheng et al.
Meng Cao et al.
Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced breast cancer, but the response to chemotherapy is unpredictable due to unknown information on the tumor drug sensitivity. Patient-derived organoids (PDOs) have rec...
Case Reports
OncoTargets and therapy. 2025 Mar 6:18:319-324. DOI:10.2147/OTT.S484293 2025
Marta Muzzana,Massimo Broggini,Giovanna Damia
Marta Muzzana
PARP inhibitors are a class of agents that have shown significant preclinical activity in models defective in homologous recombination (HR). The identification of synthetic lethality between HR defects and PARP inhibition led to several cli...
Efficacy and Safety of Combined PD-1 Inhibitor With Induction Chemotherapy Followed by IMRT Plus Nimotuzumab in Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Analysis [0.03%]
PD-1抑制剂联合诱导化疗随后进行IMRT加 Nimotuzumab在局部晚期鼻咽癌中的疗效和安全性：一项回顾性分析
Kebin Chen,Xiaopeng Huang,Jiawei Chen et al.
Kebin Chen et al.
Background: Induction chemotherapy (IC) is the standard treatment protocol for locally advanced nasopharyngeal carcinoma (LANPC), though concerns persist regarding high rates of recurrence and metastasis. This retrospecti...
Profiling the Tumor Immune Microenvironment of HPV-Associated Base of Tongue Squamous Cell Carcinoma [0.03%]
人乳头瘤病毒相关舌根鳞状细胞癌肿瘤免疫微环境的特征分析
Reham M Alahmadi,Maaweya Awadalla,Najat Marraiki et al.
Reham M Alahmadi et al.
Background: Base of tongue squamous cell carcinoma (BOTSCC) is a prevalent and aggressive form of oral cancer, often associated with poor patient outcomes. The tumor microenvironment (TME) of HPV-positive BOTSCC is critic...
Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic Strategies [0.03%]
探索TGF-β信号在癌症进展中的作用：前景与治疗策略
Khansa Ali Sheikh,Momna Amjad,Mahnoor Tabassum Irfan et al.
Khansa Ali Sheikh et al.
Cancer persists as a ubiquitous global challenge despite the remarkable advances. It is caused by uncontrolled cell growth and metastasis. The Transforming Growth Factor-beta (TGF-β) signaling pathway is considered a primary regulator of v...
Comprehensive Analysis Identifies Hsa_circ_0058191 as a Potential Drug Resistance Target in Multiple Myeloma [0.03%]
全面分析鉴定hsa_circ_0058191为多发性骨髓瘤中潜在的药物抗性靶点
Huiye Yang,Jie Zhu,Xiaotao Wang
Huiye Yang
Background: Multiple Myeloma (MM) is the second most common hematologic malignancy, which exhibits strong resistance to bortezomib, the first-line treatment. Circular RNAs (circRNAs) are increasingly considered as importa...
A Comprehensive Review of Advances in Molecular Mechanisms and Targeted Therapies for the Specific Type of Cystic Lung Cancer [0.03%]
囊性肺癌分子机制及靶向治疗进展的综合回顾
Beinuo Wang,Cheng Shen,Danlu Liu et al.
Beinuo Wang et al.
Background and objective: Cystic lung cancer (CLC) presents diagnostic and treatment challenges due to its complex imaging features and unclear molecular mechanisms. Although surgery and standard chemotherapy are frequent...
Binbin Cong,Xiaoshan Cao,Wen G Jiang et al.
Binbin Cong et al.
Breast cancer is one of the most common malignant tumours in women worldwide. A primary route for breast cancer cells to disseminate is through regional lymphatic vessels and nodes. Cancer cell-induced lymphangiogenesis plays a crucial role...
Mechanism of microRNA-152-3p-Mediated Regulation of Autophagy and Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells [0.03%]
miR-152-3p通过靶向LARS调节紫杉醇耐药卵巢癌细胞自噬和敏感性的机制研究
Di Wu,Yang Zhang,Luna Zhang et al.
Di Wu et al.
Objective: The study investigated microRNA-152-3p-mediated autophagy and sensitivity of paclitaxel-resistant ovarian cancer cells. Methods: ...
Crosstalk of SPINK4 Expression With Patient Mortality, Immunotherapy and Metastasis in Pan-Cancer Based on Integrated Multi-Omics Analyses [0.03%]
基于综合多组学分析的胰腺癌SPINK4表达与患者预后、免疫治疗和转移的关系研究
Xiuhua Cao,Na Luo,Xiaoyan Liu et al.
Xiuhua Cao et al.
Background: Cancer remains a major global health challenge, with early detection and prompt treatment being crucial for reducing mortality rates. The SPINK4 has been linked to the development of several tumors, and there ...