SNRPE is Associated with ERK/mTOR Signaling Activation and Reduced Autophagy to Promote Lung Adenocarcinoma Cell Proliferation [0.03%]
SNRPE通过与ERK/mTOR信号激活及自噬抑制相关促进肺腺癌细胞增殖
Jun Yang,Wenchao Dai,Bi Ren et al.
Jun Yang et al.
Objective: To explore the effect of small nuclear ribonucleoprotein E (SNRPE) on proliferation and autophagy in lung adenocarcinoma (LUAD). Methods: ...
Redefining Therapeutic Boundaries: PD-1 Blockade Facilitates Surgical Cure in EGFR-TKI Refractory EGFR-Mutant NSCLC with Pleural Metastases [0.03%]
突破性治疗界限：PD-1阻断联合手术切除治疗EGFR-TKI耐药伴恶性胸腔积液的EGFR突变型晚期非小细胞肺癌患者
Yong-Liang Niu,Xiao-Bao Teng,Ming-Feng Han et al.
Yong-Liang Niu et al.
We present a 57-year-old female diagnosed with stage cT3N1M1a (IVA) EGFR L858R-mutant lung adenocarcinoma (PD-L1 TPS 60%). The patient attained sustained disease control with a partial response lasting 22 months on first-line gefitinib. Fol...
Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma [Retraction] [0.03%]
FOX S1抑制肝细胞癌的发展[撤稿]
[This retracts the article DOI: 10.2147/OTT.S272596.]. © 2025 Dove Medical Press.
Targeting ANXA4 to Overcome Cisplatin Resistance in Ovarian Cancer: A Bioinformatics and in Vitro Study [0.03%]
靶向ANXA4克服卵巢癌顺铂耐药的生物信息学及体外研究
Yong Wang,Qingzhen Xie
Yong Wang
Background: Ovarian cancer is a leading cause of gynecologic cancer-related deaths, with cisplatin (DDP) resistance posing a significant challenge to effective treatment. Understanding the molecular mechanisms underlying ...
Patients with Advanced Non-Small Cell Lung Cancer and the EGFR Exon 19 Deletion p.L747 Benefit from Chemotherapy and First-Generation Tyrosine Kinase Inhibitors Compared with Patients with p.E746 [0.03%]
与p.E746相比，含铂化疗联合第一代酪氨酸激酶抑制剂较只使用一代TKI能更好的改善EGFR外显子19缺失(p.L747)的晚期非小细胞肺癌患者预后
Maojing Guan,Qingming Shi,Wei Ye et al.
Maojing Guan et al.
Purpose: Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) varies among individuals harboring exon 19 deletions (19del) at different amino acid positions and EGFR 19del or deletion-ins...
Decoding the Prognosis-Related S100A9high Monocyte in Glioblastoma Using Single-Cell and Spatial Transcriptome Sequencing [0.03%]
基于单细胞和空间转录组测序解码胶质母细胞瘤预后相关的S100A9高表达单核细胞
Xiucan Li,Ying Qin,Pengfei Gao et al.
Xiucan Li et al.
Purpose: Monocytes and macrophages are recognized as predominant immune populations in human glioblastoma, where they play vital roles in tumor progression. Despite their established significance, the heterogeneity of the...
miR-424-3p Contributes to the Malignant Progression and Chemoresistance of Gastric Cancer [Retraction] [0.03%]
MicroRNA-424-3P促进胃癌恶性进展和耐药性【撤稿】
[This retracts the article DOI: 10.2147/OTT.S280717.]. © 2025 Dove Medical Press.
Real-World Experience of Niraparib as Maintenance Therapy in Patients with Newly Diagnosed Advanced Ovarian Cancer: A Single-Center Retrospective Study [0.03%]
尼拉帕利作为新诊断的晚期卵巢癌维持治疗的单中心回顾性研究现实世界经验分析
Wenxin Liu,Li Zhang,Huijuan Wu et al.
Wenxin Liu et al.
Objective: This study aimed to evaluate the efficacy and safety of niraparib as a maintenance treatment for newly diagnosed advanced ovarian cancer in a real-world setting. ...
Metastatic Laryngeal Minor Salivary Gland Carcinoma to the Liver: Successful Treatment with Anti-EGFR-Based Combination Therapy - A Case Report and Literature Review [0.03%]
抗EGFR联合治疗转移性喉部小涎腺癌成功的病例报告及文献回顾
Zhigui Guo,Qianwen Li,Dan Hong et al.
Zhigui Guo et al.
Laryngeal minor salivary gland carcinoma is a rare malignancy, accounting for less than 1% of laryngeal cancers. We present a case of a 43-year-old male with a history of surgically resected laryngeal ductal carcinoma who developed liver me...
Evaluating the Prognostic Value of a Pan-Cancer Circulating Tumor DNA Next-Generation Sequencing Panel in Advanced Cancer Patients [0.03%]
泛癌种循环肿瘤DNA下一代测序谱板对晚期癌症患者预后价值的评估
Jaewoong Lee,Jang Ho Cho,Seungok Lee et al.
Jaewoong Lee et al.
Purpose: This study aimed to evaluate the clinical utility of a pan-cancer circulating tumor DNA (ctDNA) next-generation sequencing (NGS) panel for predicting treatment response and progression-free survival (PFS) in pati...