Coumarins from Citrus aurantiifolia (Christm.) Swingle Peel with Potential Cytotoxic Activity Against MCF-7 Breast Cancer Cell Line: In Vitro and In Silico Studies [0.03%]
柑橘属西印度 lime果皮中具有抗MCF-7乳腺癌细胞活性的香豆素类成分：体内外研究
Euis Julaeha,Faryanti Eka Mulyawan,Feby Marlia Anwar et al.
Euis Julaeha et al.
Aim: Breast cancer remains a prevalent and challenging health issue for women globally. In the pursuit of more effective and less harmful therapies, researchers have focused on natural compounds, especially phenolic compo...
Integrating Bulk and Single-Cell RNA Sequencing Data Reveals the Prognostic Significance of HOXC9-Related Immune Gene Signatures in Hepatocellular Carcinoma [0.03%]
整合大队列和单细胞RNA测序数据揭示HOXC9相关免疫基因谱在肝细胞癌预后评估中的价值
Yong Zhang,Hengliang Sun,Weibo Bo et al.
Yong Zhang et al.
Objective: This study aims to integrate bulk and single-cell RNA sequencing data to construct a risk score model based on HOXC9-related immune genes (HRIGs) and evaluate its prognostic value in hepatocellular carcinoma (H...
Genomic Insights Into Early Relapsed Breast Cancer: Prognostic Challenges and Mutation Landscape [0.03%]
基因组学视角下的早期复发乳腺癌：预后挑战与突变图谱
Yixuan Wang,Lianru Zhang,Yanan Du et al.
Yixuan Wang et al.
Purpose: Early relapsed breast cancer, characterized by recurrence within two years post-surgery, often results from drug resistance and rapid progression. The clinicopathological, prognostic and molecular features of the...
PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer [0.03%]
PCSK9在癌症中的脂质代谢和免疫微环境操纵作用
Chaochu Cui,Aiwei Yan,Shengming Huang et al.
Chaochu Cui et al.
Cancer remains the foremost cause of mortality on a global scale. Immunotherapy has yielded remarkable outcomes in the fight against cancer and is regarded as one of the most crucial and promising therapeutic modalities. PCSK9, a critical t...
Prognostic and Immunological Significance of NMNAT1 in Colorectal and Pan-Cancer Contexts [0.03%]
NMNAT1在结直肠癌及泛癌症背景下的预后和免疫学意义
Liang Wen,Ping Wang,Guosheng Zhang et al.
Liang Wen et al.
Introduction: Nicotinamide plays a critical role in the prevention and treatment of tumors, and its metabolism is closely associated with tumor progression. The aim of this study was to understand the prognostic and immun...
Evaluation of Indoleamine 2,3-Dioxygenase (IDO) Expression in Osteosarcoma: Insights From a 10-Year Retrospective Cohort [0.03%]
骨肉瘤中色氨酸酶(IDO)表达的评估：一项十年回顾性队列研究的见解
Asim Farooq,Aatif Amin,Shaarif Bashir et al.
Asim Farooq et al.
Introduction: Osteosarcoma, a prevalent bone malignancy in children and adolescents, is currently treated through surgical resection and chemotherapy. Advancements in cancer research are targeting immune checkpoint molecu...
Clinical Impact of Osimertinib Dose Reduction in the First-Line Setting on EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Retrospective Monocentric Study [0.03%]
第一线设置中奥希替尼剂量减少对EGFR突变阳性非小细胞肺癌的临床影响：一项回顾性单中心研究
Hirokazu Iso,Makiko Yomota,Yukari Shirakura et al.
Hirokazu Iso et al.
Purpose: Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. In the FLAURA trial, osimertinib demonstrated longer progression-free survival (PFS) and overall survival (OS) ...
CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP [0.03%]
循环肿瘤细胞中的CYP3A5基因多态性赋予了R-CHOP治疗的DLBCL患者更高的无病生存率
Rafael Cerón Maldonado,Adolfo Martínez Tovar,Christian Omar Ramos Peñafiel et al.
Rafael Cerón Maldonado et al.
Purpose: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous aggressive lymphoid neoplasm. Cases of refractoriness and relapse persist in approximately 40% of patients treated with first-line R-CHOP regimen, thus, th...
Multi-Omics Analysis Revealed That TAOK1 Can Be Used as a Prognostic Marker and Target in a Variety of Tumors, Especially in Cervical Cancer [0.03%]
多组学分析揭示TAOK1可用作多种肿瘤的预后标志物和靶点，尤其是在宫颈癌中的应用
Li Ning,Xiu Li,Yating Xu et al.
Li Ning et al.
Background: Thousand and One Kinase 1 (TAOK1), a member of the MAPK kinase family, plays a crucial role in processes like microtubule dynamics, DNA damage response, and neurodevelopment. While TAOK1 is linked to tumorigen...
JiaQi Liu,Jun Chu
JiaQi Liu
Background: Anaplastic thyroid cancer (ATC) is a rare, highly aggressive malignancy that accounts for less than 2% of thyroid cancers but contributes significantly to morbidity and mortality. Despite its rapid progression...
Case Reports
OncoTargets and therapy. 2025 Mar 10:18:325-333. DOI:10.2147/OTT.S504279 2025