Pan-Cancer Analysis of WRN: From Multi-Omics Biomarker Discovery to Therapy-Guiding Functional Evidence [0.03%]
泛癌WRN分析：从多组学生物标志物发现到指导治疗的功能证据
Qing-Qing Yao,Yue Qi,Pei-Qin Shi et al.
Qing-Qing Yao et al.
Background: The RecQ DNA helicase family member WRN is an important protein for maintaining genome stability. The concept of attention as a synthetic lethal target for MSI-H tumors has garnered significant attention in re...
Integrated CT Radiomics and Circulating Tumor Cell Analysis in Predicting Lung Adenocarcinoma Invasion: A Dual-Center Study with Implications for Personalized Treatment [0.03%]
基于影像组学和循环肿瘤细胞的肺腺癌侵袭性预测模型及其临床应用价值研究
Qingtao Zhao,Runzhe Wang,Qingxin Zhao et al.
Qingtao Zhao et al.
Purpose: This study aimed to construct a risk prediction model based on radiomics, circulating tumor cells (CTCs), and dual-center clinical data to predict the invasiveness of lung adenocarcinoma, specifically for discrim...
Response to Osimertinib Observed in Meningeal-Metastatic NSCLC with EGFR A763V Mutation: A Case Report and Literature Review [0.03%]
奥希替尼对EGFR A763V突变的脑膜转移NSCLC患者的疗效：一例报告及文献复习
Yu Xu,Jie Li
Yu Xu
Here, we report a case of a male patient who was initially diagnosed with stage IV driver gene-negative lung adenocarcinoma and received immune checkpoint inhibitors plus chemotherapy as first-line therapy. The patient progressed to meninge...
Case Reports
OncoTargets and therapy. 2026 Jan 21:19:571033. DOI:10.2147/OTT.S571033 2026
Design and Engineering of Recombinant Oncolytic Adenoviruses Expressing an Anti-EpCAM/Anti-CD3 BiTE for Targeted Immunotherapy of A549 Lung Cancer Cells [0.03%]
设计并绘制针对A549肺癌细胞免疫治疗的重组溶瘤腺病毒表达抗EpCAM/抗CD3双特异性T细胞接合器（BiTE）
Ensieh Taheri,Shahriyar Abdoli,Majid Shahbazi
Ensieh Taheri
Background: Oncolytic virotherapy is a novel therapeutic approach in oncology that uses viruses to target and eradicate cancer cells specifically. To improve therapeutic effectiveness, we investigated the application of g...
Erratum: MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4 [Corrigendum] [0.03%]
MiR-6165通过靶向STRN4抑制胃癌迁移和侵袭的微小核糖核酸谱系更正
[This corrects the article DOI: 10.2147/OTT.S208024.]. © 2026 Wang et al.
Published Erratum
OncoTargets and therapy. 2026 Mar 11:19:608224. DOI:10.2147/OTT.S608224 2026
Diagnostic Performance of Circulating miRNA-92a and Related Circulating miRNA Panels for Colorectal Cancer: An Updated Systematic Review and Meta-Analysis [0.03%]
循环miRNA-92a及其相关循环miRNA联合检测用于结直肠癌诊断的系统评价和 meta 分析
Rosmeri Handayani,Siti Hamidatul Aliyah,Muhammad Begawan Bestari et al.
Rosmeri Handayani et al.
Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide and the third most frequently diagnosed malignancy. Circulating microRNAs, particularly miRNA-92a, have gained prominen...
NG25 Enhances Anti-Tumor Immunity in KRAS-Mutant Colorectal Cancer [0.03%]
NG25可增强KRAS突变型结直肠癌的抗肿瘤免疫应答
Qi Xiang,Zhigang Mao,Qizhao Ma et al.
Qi Xiang et al.
Purpose: The poor prognosis of KRAS-mutant colorectal cancer is attributed to its immunosuppressive tumor microenvironment and the lack of effective targeted therapies. Transforming growth factor-β-activated kinase 1 (TA...
Research Progress on the Molecular Mechanism of Metformin Regulating AMPK Signaling Pathway in Inhibiting Liver Cancer [0.03%]
二甲双胍通过AMPK信号通路抑制肝癌的研究进展分子机制研究
Hong Bin Zhang,Yan Yan,Jin Peng Pang et al.
Hong Bin Zhang et al.
Liver cancer is one of the common malignant tumors worldwide and ranks among the top in cancer mortality statistics. In recent years, metformin, as a first-line drug with significant efficacy and low cost, has been widely used in clinical p...
The Role of DNA Methylation in Osteosarcoma Pathogenesis and Therapy [0.03%]
DNA甲基化在骨肉瘤发生发展及治疗中的作用研究进展
Xiaolan Zhou,Bingbing Li,Peigan Tao
Xiaolan Zhou
Osteosarcoma (OS) is a highly malignant bone tumor primarily affecting children and adolescents. Clinical treatment has consistently encountered challenges, including chemotherapy resistance, high recurrence rates, and metastasis. Research ...
MST4 Regulates Epithelial-Mesenchymal Transition of Choriocarcinoma by Mediating TGF-β1 Expression [Retraction] [0.03%]
MST4通过介导TGF-β1表达调节绒毛膜癌上皮间质转化[撤稿]
[This retracts the article DOI: 10.2147/OTT.S269168.]. © 2026 Dove Medical Press.