A Pyroptosis-Related LncRNA Signature for Predicting Prognosis, Immune Features and Drug Sensitivity in Ovarian Cancer [0.03%]
用于预测卵巢癌预后、免疫特征和药物敏感性的与焦亡相关的长链非编码RNA标志物
Po-Wu Liu,Zhao-Yi Liu,Shi-Jia Deng et al.
Po-Wu Liu et al.
Background: Multiple studies have suggested that lncRNAs and pyroptosis play important roles in ovarian cancer (OC). However, the function of pyroptosis-related lncRNAs (PRLs) in OC is not fully understood. ...
Based on Soluble Immune Checkpoints Constructing a Random Survival Forest Model to Predict the Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma [0.03%]
基于可溶性免疫检查点构建随机生存森林模型预测乙型肝炎病毒相关肝细胞癌预后
Xue Cai,Lihua Yu,Xiaoli Liu et al.
Xue Cai et al.
Background: Nowadays, immune checkpoint blockade (ICB) therapy has become a milestone in immunotherapy for hepatocellular carcinoma (HCC). However, its clinical effectiveness remains low. Soluble (s) immune checkpoints (I...
Combination of Aumolertinib, Dabrafenib, and Trametinib for a Patient with Advanced Lung Adenocarcinoma with an Osimertinib-Induced BRAF V600E Mutation: A Case Report [0.03%]
奥玛尔替尼、达拉菲尼和曲美替尼联合治疗一例奥希替尼诱导的BRAF V600E突变晚期肺腺癌患者：个案报告
Diming Wang,Wei Ye,Zihuan Yin et al.
Diming Wang et al.
Osimertinib has become the standard of care in the first-line treatment of advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Although previous studies reported that the BRAF V600E mutat...
Case Reports
OncoTargets and therapy. 2025 Apr 13:18:539-544. DOI:10.2147/OTT.S512704 2025
Yangyang Li,ZhongQuan Yi,Xia Li et al.
Yangyang Li et al.
Receptors coupled with G proteins (GPCRs) are expressed in large numbers in multiple systems, such as endocrine, cardiovascular, digestive, immune, and reproductive systems. As an important signal transduction mediator, in recent years, the...
Integrated Genomic Analysis of Lung Squamous Cell Carcinoma Subtypes Characterized by Immunogenic Cell Death-Relevant Gene Signature [0.03%]
基于与免疫原性细胞死亡相关的基因特征的肺鳞癌亚型综合基因组分析
Yuhan Wang,Shuang Wang,Ran Ding et al.
Yuhan Wang et al.
Purpose: The objective of this study was to identify biomarkers associated with immunogenic cell death (ICD) in lung squamous cell carcinoma (LUSC), focusing on subtypes with distinct immunological characteristics and pro...
Management of Regorafenib-Induced Hand-Foot Skin Reaction with Topical Chinese Medicine and Urea Ointment: A Case Report and Literature Review [0.03%]
中药外用联合尿素软膏治疗瑞戈非滨致掌跖皮肤反应1例及文献复习
Zhe-Ning Liu,Yu-Lei Shen,Hui-Jing Dong et al.
Zhe-Ning Liu et al.
Regorafenib, a multikinase inhibitor, frequently induces severe hand-foot skin reactions (HFSR), often requiring dose reduction or discontinuation. This case report demonstrates the successful management of HFSR in a patient with fibromyxoi...
Case Reports
OncoTargets and therapy. 2025 Apr 9:18:509-519. DOI:10.2147/OTT.S510766 2025
Neoadjuvant Targeted Therapy with Dacomitinib in a Stage IIIA Non-Small-Cell Lung Cancer Patient Harboring EGFR G719X: A Case Report [0.03%]
达可替尼新辅助治疗EGFR G719X突变的IIIa期非小细胞肺癌患者：病例报告
Dan Li,Xin Liu,Yang Liu et al.
Dan Li et al.
The effectiveness of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) has been established, leading the NCCN Guidelines to recommend it as a first-line treatment for patients with advanced EGFR mutation-positive non-s...
Case Reports
OncoTargets and therapy. 2025 Apr 5:18:503-507. DOI:10.2147/OTT.S502112 2025
Waldenström Macroglobulinemia and Chronic Myelomonocytic Leukemia: Case Report and Literature Review [0.03%]
瓦尔登斯特伦巨球蛋白血症和慢性嗜酸性粒细胞白血病1例及文献复习
Yueyue Pan,Yan Wang,Qiong Wang
Yueyue Pan
As hematological tumor patients are surviving long-term, the long-term toxicities of therapeutic regimens have become increasingly evident. The coexistence of two hematological tumors in the same patient is extremely rare and typically show...
Case Reports
OncoTargets and therapy. 2025 Apr 3:18:481-487. DOI:10.2147/OTT.S483011 2025
Anti-Tumor Effects of Gilteritinib on FLT3 Mutations: Insights into Resistance Mechanisms in Ba/F3 Cell Models [0.03%]
Gilteritinib靶向FLT3突变的抗肿瘤作用及Ba/F3细胞模型中的耐药机制研究
Taisuke Nakazawa,Hirofumi Tsuzuki,Tatsuya Kawase et al.
Taisuke Nakazawa et al.
Background: The efficacy of Fms-like tyrosine kinase 3 (FLT3) inhibitors has been well established against acute myeloid leukemia (AML) with FLT3 internal tandem duplication (FLT3-ITD) mutations. However, comparative data...
Exploring Protein Expression Profiles in Lung Cancer Insufficient Microwave Ablation: Implications for Recurrence [0.03%]
肺癌微波消融不足的蛋白质表达谱特征及其复发意义探讨
Peng Yan,Ruimei Yuan,Zheng Li et al.
Peng Yan et al.
Background: Insufficient ablation is a significant factor contributing to the recurrence of non-small cell lung cancer (NSCLC), and it is of great significance to explore the protein expression profile of lung cancer cell...