Influence of Human Papillomavirus E6 Gene Mutation on Brain-Derived Neurotrophic Factor Regulation and Cell Proliferation in Cervical Neoplasia: Insights Into Molecular Mechanisms [0.03%]
人乳头瘤病毒E6基因突变对宫颈肿瘤组织中脑源性神经营养因子调控及细胞增殖的影响：分子机制探讨
Ling Wei,Qian Yu,Su-Ning Chen
Ling Wei
Objective: To investigate the effects and mechanisms of human papillomavirus E6 (HPV16 E6) gene mutation on cervical cancer and cervical intraepithelial neoplasia grade I (CIN I) cell proliferation by regulating brain-der...
Vitamin C Selectively Inhibits Kidney Renal Clear Cell Carcinoma Cell Growth by Suppressing the HIF-1 Pathway [0.03%]
维生素C通过抑制HIF-1信号途径选择性地抑制肾透明细胞癌系的生长
Che Wang,Yaoyang Zhou,Yu Liang et al.
Che Wang et al.
Aim: To observe the effect of vitamin C on Kidney renal clear cell carcinoma (KIRC) and investigate its mechanism. Methods and results: ...
Could Silent Inflammation Originating in Jawbone Cavitations Play a Role in Activating the CCL5/CCR5 Axis in Female Breast Cancer? A Diagnostic and Therapeutic Gap in Osteoimmunological Interactions [0.03%]
牙骨质中沉默炎症是否会激活女性乳腺癌的CCL5/CCR5轴？关于骨免疫相互作用的诊断和治疗差距
Joana Vasconcelos E Cruz,Sebastjan Perko,Cornelia Doebis et al.
Joana Vasconcelos E Cruz et al.
Introduction: Breast cancer (BC) is one of the leading causes of cancer mortality worldwide. The chemokine CCL5 and its receptor CCR5 have been demonstrated to be associated with tumour progression, immune evasion, and me...
Serum Response Factor Expression, Microvascular Density, and Postoperative Recurrence in Glioblastoma [0.03%]
胶质母细胞瘤中血清反应因子表达、微血管密度与术后复发的关系
Bo Tan,Shuangyin He,Tao Chen et al.
Bo Tan et al.
Objective: To investigate the association between serum response factor (SRF) expression, tumour microvascular density (MVD), and postoperative recurrence in glioblastoma. ...
Glycolysis-Driven Immune Evasion in Microsatellite Instability-High Colorectal Cancer: An Integrated Single-Cell and Spatial Transcriptomics Study [0.03%]
微卫星不稳定型结直肠癌中以糖酵解驱动的免疫逃逸现象：单细胞及空间转录组学整合分析
Chenchen Li,Peicong Cai,Hengda Zeng et al.
Chenchen Li et al.
Purpose: Microsatellite instability-high colorectal cancer is characterized by hypermutated genomes and high neoantigen loads, yet a significant proportion of patients exhibit resistance to immune checkpoint blockade. Thi...
Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate? [0.03%]
乳腺导管状肌上皮癌能从TROP2抗体药物偶联物中获益吗？
Qing Zhao,Xiao Luo,Hua Xing et al.
Qing Zhao et al.
Epithelial-myoepithelial carcinoma (EMC) of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Breast epithelial myoepithelial carcinoma lacks therapeutic strategies due to its rari...
The Immunomodulatory Activity of Thymosin Alpha 1 on Tumor Cell Lines and Distinct Immune Cell Subsets [0.03%]
胸腺素α1调节肿瘤细胞系和特异性免疫细胞亚群的免疫调控作用
Laura Solmonese,Maria Fortunata Lofiego,Carolina Fazio et al.
Laura Solmonese et al.
Background: The immune-balancing role of thymosin alpha 1 (Tα1) is well-recognized in contexts of immune dysregulation. Within the anti-tumor context, Tα1 demonstrated to act as an immune-enhancer, with potential roles ...
The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity [0.03%]
RBBP7在食管鳞状细胞癌中的双重作用：细胞背景依赖的增殖和放射敏感性影响
Yafen Li,Shuai Lu,Hui Yao et al.
Yafen Li et al.
Background: Radiotherapy resistance contributes to poor prognosis in esophageal squamous cell carcinoma (ESCC). Retinoblastoma-binding protein 7 (RBBP7) is a nuclear protein, and it can promote or inhibit tumor progressio...
Mi-Lnc70 Regulates the Progression of Murine Pancreatic β-Cell Line and Affects the Synthesis of Insulin and Glucagon [0.03%]
Mi-Lnc70调节小鼠胰岛β细胞系的进展并影响胰岛素和 glucagon的合成
Wen Yuan,Dongxue Sun,Jing Wang et al.
Wen Yuan et al.
Background: Insulinoma, the most common type of pancreatic endocrine tumor, frequently induces hypoglycemia due to persistent hyperinsulinemia. Although Mi-Lnc70 expression progressively increases during pancreatic matura...
Immunotherapy Resistance and Therapeutic Strategies in PD-L1 High Expression Non-Small Cell Lung Cancer [0.03%]
PD-L1高表达非小细胞肺癌的免疫治疗耐药及应对策略
Jianhua Liu,Yin Cai,Jiang Liu et al.
Jianhua Liu et al.
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and high programmed death-ligand 1 (PD-L1) expression (≥50%) is a key biomarker for predicting clinical benefit from immune checkpoint inhibitors (ICIs). This th...