Personalized Treatment for Invasive Ductal Breast Carcinoma with Lung and Liver Metastases Based on Patient-Derived Organoids: A Case Report [0.03%]
基于患者来源类器官的侵袭性导管乳腺癌伴肺和肝转移的个性化治疗：病例报告
Miaoli Zheng,Liang Yao,Na Jing et al.
Miaoli Zheng et al.
Patient-derived organoids (PDOs) are emerging as a potential preclinical tool in assessing cancer patients' responses to various therapies. Here, we first described a case of invasive ductal breast carcinoma with lung and liver metastases w...
L-Sarcolysine Reduced the Mobility of Human Glioblastoma Cells, with Potential Involvement of Vimentin [0.03%]
L-肉毒碱减少人胶质母细胞瘤细胞迁移能力及其对波形蛋白的潜在影响
Parastoo Azadbeigi,Negin Moosavinejad,Fatemeh B Rassouli
Parastoo Azadbeigi
Background: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis, highlighting the need for novel therapeutic approaches. Vimentin plays a critical role in cancer cell motility, with elevat...
Advances in the Use of Immune Checkpoint Inhibitors for Colorectal Cancer Treatment [0.03%]
免疫检查点抑制剂用于结直肠癌治疗的研究进展
Jianing Li,Tong Fu,Zhu Wen et al.
Jianing Li et al.
Purpose: Colorectal cancer (CRC) is a highly prevalent malignant tumor worldwide, and the emergence of immune checkpoint inhibitors (ICIs) has changed CRC immunotherapy. This systematic review aims to provide a comprehens...
Analysis and Exploration of the Relationship Between the Status of Serum Tumor Markers and Clinicopathological Features and Curative Effects in Gastric Cancer and Gastroesophageal Junction Tumor [0.03%]
胃癌及胃食管结合部肿瘤血清肿瘤标志物状态与临床病理特征和疗效关系的分析和探索
Yifan Xiao,Zhenzhu Xing,Zhaobing Li et al.
Yifan Xiao et al.
Background: The detection of tumor markers for predicting the therapeutic efficacy is relatively rare at present. The combined elevation of carcinoembryonic antigen (CEA), CA19-9, CA72-4, and CA125 and others may predict ...
Precision Nanomedicine for Cancer: Innovations, Strategies, and Translational Challenges [0.03%]
癌症精准纳米医学：创新、策略与转化挑战
Fuxing Wen,Lishuang Wang,Xian Li et al.
Fuxing Wen et al.
As nanotechnology advances rapidly, it has propelled nanomedicine into a revolutionary frontier for anticancer therapy. This review comprehensively analyzes the core principles, key innovations, and strategic approaches driving the developm...
Development of a Prognostic m6A-Related lncRNA Signature and Functional Validation of FAM83A-AS1 in Lung Adenocarcinoma [0.03%]
开发肺腺癌预后m6A相关lncRNA标志物及FAM83A-AS1功能验证
Guojun Zhang,Cheng Liu,Yukun Wang
Guojun Zhang
Introduction: This work aimed to identify m6A-related long non-coding RNAs (lncRNAs) associated with lung adenocarcinoma (LUAD) and evaluate their prognostic value and to examine the oncogenic actions of FAM83A-AS1 in LUA...
Ebp1 p48 Promotes Oncogenic Properties in Non-Small Cell Lung Cancer Through PI3K/Akt Signaling Pathways [0.03%]
Ebp1 p48通过PI3K/Akt信号通路促进非小细胞肺癌的致癌特性
Lina Ma,Shuyuan Wang,Jia Zhang et al.
Lina Ma et al.
Purpose: Lung cancer, particularly non-small cell lung cancer (NSCLC), is highly deadly globally. The potential carcinogenic role of p48, a long isoform of ErbB3-binding protein 1 (Ebp1), is well established in other canc...
Influence of Human Papillomavirus E6 Gene Mutation on Brain-Derived Neurotrophic Factor Regulation and Cell Proliferation in Cervical Neoplasia: Insights Into Molecular Mechanisms [0.03%]
人乳头瘤病毒E6基因突变对宫颈肿瘤组织中脑源性神经营养因子调控及细胞增殖的影响：分子机制探讨
Ling Wei,Qian Yu,Su-Ning Chen
Ling Wei
Objective: To investigate the effects and mechanisms of human papillomavirus E6 (HPV16 E6) gene mutation on cervical cancer and cervical intraepithelial neoplasia grade I (CIN I) cell proliferation by regulating brain-der...
Vitamin C Selectively Inhibits Kidney Renal Clear Cell Carcinoma Cell Growth by Suppressing the HIF-1 Pathway [0.03%]
维生素C通过抑制HIF-1信号途径选择性地抑制肾透明细胞癌系的生长
Che Wang,Yaoyang Zhou,Yu Liang et al.
Che Wang et al.
Aim: To observe the effect of vitamin C on Kidney renal clear cell carcinoma (KIRC) and investigate its mechanism. Methods and results: ...
Could Silent Inflammation Originating in Jawbone Cavitations Play a Role in Activating the CCL5/CCR5 Axis in Female Breast Cancer? A Diagnostic and Therapeutic Gap in Osteoimmunological Interactions [0.03%]
牙骨质中沉默炎症是否会激活女性乳腺癌的CCL5/CCR5轴？关于骨免疫相互作用的诊断和治疗差距
Joana Vasconcelos E Cruz,Sebastjan Perko,Cornelia Doebis et al.
Joana Vasconcelos E Cruz et al.
Introduction: Breast cancer (BC) is one of the leading causes of cancer mortality worldwide. The chemokine CCL5 and its receptor CCR5 have been demonstrated to be associated with tumour progression, immune evasion, and me...