Dynamic Coupling of MAPK Signaling to the Guanine Nucleotide Exchange Factor GEF-H1 [0.03%]
MAPK信号转导与鸟苷核苷酸交换因子GEF-H1的动态偶联现象
Kévin Leguay,Oliver A Kent
Kévin Leguay
The KRAS gene is nearly ubiquitously subjected to activating mutation in pancreatic adenocarcinomas (PDAC), occurring at a frequency of over 90% in tumors. Mutant KRAS drives sustained signaling through the MAPK pathway to affect frequently...
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors [0.03%]
探索和识别维生素D及相关基因作为结直肠肿瘤潜在生物标志物的研究
Lu Wang,Ruize Xu,Mizhu Wang et al.
Lu Wang et al.
Objective: To explore the relationship and underlying mechanisms between vitamin D and CRC, offering valuable insights into the diagnosis and treatment of CRC. ...
Pan-Cancer Analysis Identifies YKT6 as a Prognostic and Immunotherapy Biomarker, with an Emphasis on Cervical Cancer [0.03%]
泛癌分析鉴定出YKT6是预后和免疫治疗生物标志物，在宫颈癌中尤为显著
Jiamin Liu,Qiang Zhang,Ling He et al.
Jiamin Liu et al.
Background: Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is crucial for autophagy, making YKT6, a key modulator of cell membrane fusion, a potential target for can...
Hao Wu,Qi Liu,Fenglu Wang et al.
Hao Wu et al.
NK cells are a type of antitumor immune cell with promising clinical application, following T cells. The activity of NK cells is primarily regulated by their surface receptors and immune microenvironment. In gliomas, the tumor microenvironm...
Prognostic Value of Pretreatment Carcinoembryonic Antigen (CEA) in Rectal Cancer Treated with Preoperative Short-Course Radiotherapy with Delayed Surgery or Long-Course Radiotherapy [0.03%]
术前卡波氏胚胎抗原(CEA)对辅助短疗程放疗推迟手术或长疗程放疗直肠癌预后的影响
Yun-Hsuan Lin,Hsuan-Chih Hsu,Eng-Yen Huang
Yun-Hsuan Lin
Purpose: To investigate the prognostic value of the pretreatment serum carcinoembryonic antigen (CEA) level in patients with rectal cancer treated by preoperative short-course radiotherapy (SCRT) followed by chemotherapy ...
Roles of SPOCK1 in the Formation Mechanisms and Treatment of Non-Small-Cell Lung Cancer and Brain Metastases from Lung Cancer [0.03%]
SPOCK1在非小细胞肺癌及其脑转移形成机制及治疗中的作用
Xuebing Zhang,Xia Zhang,Hang Yin et al.
Xuebing Zhang et al.
Lung cancer is a malignant tumor with high morbidity and mortality in China and worldwide. Once it metastasizes to the brain, its prognosis is very poor. Brain metastases are found in about 20% of newly diagnosed non-small-cell lung cancer ...
Integrated Network Pharmacology, Machine Learning and Experimental Validation to Identify the Key Targets and Compounds of TiaoShenGongJian for the Treatment of Breast Cancer [0.03%]
网络药理学、机器学习及实验验证相结合寻找调神功健治疗乳腺癌的关键靶点及活性成分
Huiyan Ying,Weikaixin Kong,Xiangwei Xu
Huiyan Ying
Background: TiaoShenGongJian (TSGJ) decoction, a traditional Chinese medicine for breast cancer, has unknown active compounds, targets, and mechanisms. This study identifies TSGJ's key targets and compounds for breast can...
High Intelectin-1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer [0.03%]
高水平高迁移率族蛋白1与直肠癌侵袭行为及预后不良有关
Chia-Lin Chou,Cheng-Wei Lin,Wan-Shan Li et al.
Chia-Lin Chou et al.
Background: Multimodal treatment involving preoperative chemoradiotherapy (CRT) followed by surgery is the current standard of care for rectal cancer. Despite advancements, the risk of recurrence, metastasis, and decrease...
A Rare Case of Post-Transplant Lymphoproliferative Disorder Presenting as Hodgkin Lymphoma After Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review [0.03%]
自体造血干细胞移植后以霍奇金淋巴瘤形式出现的移植后淋巴增生性疾病的罕见病例报告及文献复习
Yuzhan Chen,Ying Chen,Yimin He et al.
Yuzhan Chen et al.
Post-transplant lymphoproliferative disorder (PTLD) is a rare complication following hematopoietic stem cell transplantation (HSCT), with its occurrence post-autologous hematopoietic stem cell transplantation (auto-HSCT) being even rarer. R...
Case Reports
OncoTargets and therapy. 2025 Jan 14:18:27-33. DOI:10.2147/OTT.S490591 2025
Recent Advances in Understanding the Clinical Responses of Brentuximab Vedotin in Lymphoma and the Correlation with CD30 Expression [0.03%]
布雷西伐单抗治疗淋巴瘤的临床疗效研究进展及其与CD30表达的相关性
Wen Chen,Zhihong Zhang
Wen Chen
Brentuximab vedotin (BV) is an antibody-drug conjugate that combines the CD30 monoclonal antibody with the microtubule-disrupting agent, monomethyl auristatin E, which induces apoptosis in the tumor cell upon its release from the conjugate....