Integrative Multi-Omics and Functional Characterization Reveal MCM4 as a Key Oncogenic Regulator in Hepatocellular Carcinoma [0.03%]
整合多组学和功能表征揭示MCM4是肝细胞癌的关键致癌调节因子
Min Qiu,Li Xu
Min Qiu
Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with limited therapeutic options and poor prognosis. Identifying robust prognostic biomarkers and therapeutic targets is essential for improving pat...
Diagnosis and Management of Colorectal Cancer in the Gulf Area: Current Practice and Future Suggestions from Expert Opinions [0.03%]
海湾地区结直肠癌的诊断和治疗：当前实践及专家意见展望
Humaid O Al-Shamsi,Kakil Rasul Snr,Alaaeldin Shablak et al.
Humaid O Al-Shamsi et al.
Colorectal cancer (CRC) is one of the most diagnosed cancers, leading to considerable cancer-related deaths globally. Recently, a notable increase has been observed in annual CRC incidence rates, particularly among individuals aged ≤50 yea...
Icariin Inhibits Lung Adenocarcinoma Progression Through TP53-Mediated Ferroptosis [0.03%]
淫羊藿次生代谢产物/icaritin通过TP53介导的铁死亡抑制肺腺癌进展
Qihua Jin,Li OuYang,Jingjing Li et al.
Qihua Jin et al.
Purpose: Lung adenocarcinoma (LUAD) represents the predominant histological subtype of non-small cell lung cancer (NSCLC) and is linked to a diminished overall survival (OS) rate. Icariin (ICA), the principal bioactive co...
SNRPE is Associated with ERK/mTOR Signaling Activation and Reduced Autophagy to Promote Lung Adenocarcinoma Cell Proliferation [0.03%]
SNRPE通过与ERK/mTOR信号激活及自噬抑制相关促进肺腺癌细胞增殖
Jun Yang,Wenchao Dai,Bi Ren et al.
Jun Yang et al.
Objective: To explore the effect of small nuclear ribonucleoprotein E (SNRPE) on proliferation and autophagy in lung adenocarcinoma (LUAD). Methods: ...
Redefining Therapeutic Boundaries: PD-1 Blockade Facilitates Surgical Cure in EGFR-TKI Refractory EGFR-Mutant NSCLC with Pleural Metastases [0.03%]
突破性治疗界限：PD-1阻断联合手术切除治疗EGFR-TKI耐药伴恶性胸腔积液的EGFR突变型晚期非小细胞肺癌患者
Yong-Liang Niu,Xiao-Bao Teng,Ming-Feng Han et al.
Yong-Liang Niu et al.
We present a 57-year-old female diagnosed with stage cT3N1M1a (IVA) EGFR L858R-mutant lung adenocarcinoma (PD-L1 TPS 60%). The patient attained sustained disease control with a partial response lasting 22 months on first-line gefitinib. Fol...
Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma [Retraction] [0.03%]
FOX S1抑制肝细胞癌的发展[撤稿]
[This retracts the article DOI: 10.2147/OTT.S272596.]. © 2025 Dove Medical Press.
Targeting ANXA4 to Overcome Cisplatin Resistance in Ovarian Cancer: A Bioinformatics and in Vitro Study [0.03%]
靶向ANXA4克服卵巢癌顺铂耐药的生物信息学及体外研究
Yong Wang,Qingzhen Xie
Yong Wang
Background: Ovarian cancer is a leading cause of gynecologic cancer-related deaths, with cisplatin (DDP) resistance posing a significant challenge to effective treatment. Understanding the molecular mechanisms underlying ...
Patients with Advanced Non-Small Cell Lung Cancer and the EGFR Exon 19 Deletion p.L747 Benefit from Chemotherapy and First-Generation Tyrosine Kinase Inhibitors Compared with Patients with p.E746 [0.03%]
与p.E746相比，含铂化疗联合第一代酪氨酸激酶抑制剂较只使用一代TKI能更好的改善EGFR外显子19缺失(p.L747)的晚期非小细胞肺癌患者预后
Maojing Guan,Qingming Shi,Wei Ye et al.
Maojing Guan et al.
Purpose: Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) varies among individuals harboring exon 19 deletions (19del) at different amino acid positions and EGFR 19del or deletion-ins...
Decoding the Prognosis-Related S100A9high Monocyte in Glioblastoma Using Single-Cell and Spatial Transcriptome Sequencing [0.03%]
基于单细胞和空间转录组测序解码胶质母细胞瘤预后相关的S100A9高表达单核细胞
Xiucan Li,Ying Qin,Pengfei Gao et al.
Xiucan Li et al.
Purpose: Monocytes and macrophages are recognized as predominant immune populations in human glioblastoma, where they play vital roles in tumor progression. Despite their established significance, the heterogeneity of the...
miR-424-3p Contributes to the Malignant Progression and Chemoresistance of Gastric Cancer [Retraction] [0.03%]
MicroRNA-424-3P促进胃癌恶性进展和耐药性【撤稿】
[This retracts the article DOI: 10.2147/OTT.S280717.]. © 2025 Dove Medical Press.