X Le Loët,M De Bandt,F Lioté et al.
X Le Loët et al.
The interactions between pregnancy and adult-onset Still's disease are unclear. Nine pregnancies which occurred from 1983 through 1991 in seven women (mean age 27.7 years; range 23-40) were studied retrospectively. Five patients had one pre...
G Bouvenot,M Vray
G Bouvenot
J Pouchot
J Pouchot
Health status is commonly appreciated with classical clinical, laboratory, or radiographic features. Quality of life measurement has been recently included in the health status evaluation in order to appreciate how individuals perceive the ...
[Risks of severe digestive adverse effects of NSAIDs. Evaluation methods of mucoprotective drugs] [0.03%]
[非甾体抗炎药严重胃肠不良反应的风险. 胃粘膜保护药物的评价方法]
J C Delchier,E Belda
J C Delchier
Frequency and severity of digestive adverse events due to NSAIDs are not similarly estimated by rheumatologists and gastroenterologists. A recent meta-analysis showed that NSAIDs users were at approximately three times greater relative risk...
A Taccoen,L Berdah
A Taccoen
Diacerhein is an anthraquinone derivative which is the active ingredient in ART 50. Its unique pharmacological activity involves inhibition of interleukin 1 and cartilage-degrading enzymes. In well-known animal models (carrageenin-induced o...
[Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit] [0.03%]
[Diacetylrhein在兔挫伤性实验骨关节炎模型中的作用]
B Mazières,L Berdah,M Thiéchart et al.
B Mazières et al.
The "chondroprotective" activity of a drug must be tested not only in vitro but also in vivo. Because this would require several years in humans, animal models of osteoarthritis are used. A closed contusion of the patella caused by the impa...
Clinical Trial
Revue du rhumatisme (Ed. francaise : 1993). 1993 Jul;60(6 Pt 2):77S-81S. DOI: 1993
[Effect of diacerhein (ART 50) on the matrix synthesis and collagenase secretion by cultured joint chondrocytes in rabbits] [0.03%]
二醋基癌醌(art-50)对培养的兔关节软骨细胞基质合成及胶原酶分泌的作用
M Boittin,F Rédini,G Loyau et al.
M Boittin et al.
Cultured rabbit joint chondrocytes were exposed to diacerhein (DAR : ART 50, Negma, 10(-6) to 10(-4) M), which has proved effective and safe when given for two months for the treatment of osteoarthritis. Experiments were performed with and ...
E Levy,A Ferme,D Perocheau et al.
E Levy et al.
The purpose of this study was to quantify the social and financial burden imposed by osteoarthritis in France. Six million new diagnoses of osteoarthritis are reported each year in France. The number of physician visits for osteoarthritis t...
D H Neustadt
D H Neustadt