Zaohua Huang,Elena M Kaftanovskaya,Bryan Rivas et al.
Zaohua Huang et al.
Global ablation of INSL3 hormone or its receptor RXFP2 in male mice results in cryptorchidism and infertility. Using novel LacZ knock-in Rxfp2 allele we demonstrated a strong expression of this gene in postmeiotic germ cells. RXFP2 was expr...
Maristela T Pimenta,Catarina S Porto,Maria F M Lazari
Maristela T Pimenta
Spermatogenesis is controlled by FSH, testosterone and paracrine factors produced by Sertoli cells. The knockout of relaxin decreases sperm maturation in mice. Studies from our laboratory have shown that relaxin and its receptor RXFP1 are e...
Aline R Nascimento,Maristela T Pimenta,Thais F G Lucas et al.
Aline R Nascimento et al.
Immature Sertoli cells proliferate and several factors affect their number, including the follicle stimulating hormone (FSH), testosterone, estradiol and several paracrine growth factors. Using a primary culture of Sertoli cells isolated fr...
Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes [0.03%]
公猪睾丸中RLF / INSL3受体RXFP2的表达和定位
Tetsuya Kohsaka,Dai Sagata,Itaru Minagawa et al.
Tetsuya Kohsaka et al.
This study investigated the possibility of the presence of specific receptor for relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) in boar testes. While RLF/INSL3 was produced by Leydig cells in the boar testis, its own receptor RXFP...
Frederico G Rocha,Jaime S Horton,Gillian D Bryant-Greenwood
Frederico G Rocha
Preterm birth (PTB) is a global problem with a high incidence in the developing world. Relaxin (RLN) has classically been associated with parturition, but its role(s) in the human have been difficult to determine. For the first time, we bri...
Laura T Goldsmith
Laura T Goldsmith
Elucidating the role(s) of relaxin in women has been greatly hampered by its species specificity. Suitable experimental models of relaxin action in women are limited. We established a non-human primate model of early human pregnancy to stud...
Gerson Weiss
Gerson Weiss
In primate pregnancy, circulating relaxin, solely a product of the corpus luteum, peaks in the first trimester of pregnancy then declines and levels off for the remainder of pregnancy. Relaxin actions in pregnancy include increasing cervica...
Carol A Bagnell,Frank F Bartol
Carol A Bagnell
A window of opportunity for maternal programming of neonatal development is open in the first few days of life as a consequence of nursing. Colostrum (first milk) supports neonatal development by providing a conduit for delivery of milk-bor...
Aydar Sabirov,Rong-Ming Lyu,Xiang-Qun Chen et al.
Aydar Sabirov et al.
We have developed a cysteine anchoring method for the synthesis of DILP8 and its analogues. The first is to synthesis of DILP8A SS13-18, C14-MeOBzl, C24-Acm and activate it as DILP8A S13-18, C14-SSPyr C24-Acm. A next step is to synthesize t...
Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1 [0.03%]
慢病毒递送microRNA干扰人RXFP1基因建立人细胞敲减模型
K L Yong,G E Callander,R Bergin et al.
K L Yong et al.
To study the specific actions of relaxin through RXFP1 in human cells, it would be advantageous to develop cell populations with permanent RXFP1 knockdown (KD). We have developed and assessed four microRNA against human RXFP1. One of the fo...