In vitro model based on human keratinocyte to evaluate relaxin activity on wound healing exploiting time-lapse video microscopy [0.03%]
基于人类角质形成细胞的体外模型，利用延时视频显微镜技术评估松弛素对伤口愈合的作用
Antonietta Stellavato,Donatella Cimini,Rosario Finamore et al.
Antonietta Stellavato et al.
Wound repair is a well-ordered but complex process involving many cellular activities including inflammation, growth factor and cytokine production, and thus cell migration and proliferation. In vitro wound healing assays have been used and...
Porcine derived relaxin stimulates new vessel formation and improves the disturbed wound healing of the genetically diabetic mice [0.03%]
从猪源relaxin刺激新生血管形成并改善遗传性糖尿病小鼠受损的伤口愈合功能
Francesco Squadrito,Alessandra Bitto,Natasha Irrera et al.
Francesco Squadrito et al.
Diabetic mice are characterized by an altered expression pattern of VEGF, and impaired vasculogenesis during healing. We investigated the effects of porcine derived relaxin in diabetes-related wound healing defects in genetically diabetic m...
Mechanisms for relaxin's modulation of MMPs and matrix loss in fibrocartilages [0.03%]
Relaxin通过调节基质金属蛋白酶和基质丢失来保护间充质组织中的软骨matrix
Sunil Kapila,Young Park,Nisar Ahmad et al.
Sunil Kapila et al.
Anti-arthritic actions of relaxin, in combination with estrogens, in joint and bone tissue [0.03%]
与雌激素联合使用时Relaxin在关节和骨组织中的抗炎作用
Carol A Bagnell,Karen Santora,Teh-Yuan Ho
Carol A Bagnell
The incidence and severity of rheumatoid arthritis decline during pregnancy. However, the role of hormones of pregnancy, including estrogens and relaxin, in attenuating the symptoms of rheumatoid arthritis, including joint inflammation and ...
Masaki Tanaka,Eriko Furube,Miku Aoki et al.
Masaki Tanaka et al.
Relaxin-3 is a neuropeptide belonging to the relaxin/insulin superfamily. Studies using rodents have revealed that relaxin-3 is predominantly expressed in neurons in the nucleus incertus of the pons, projecting axons to forebrain regions in...
Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice [0.03%]
药理学激活RXFP3在C57BL/6J小鼠中不具食欲刺激作用
Craig M Smith,Ihaia T Hosken,Natalie L Downer et al.
Craig M Smith et al.
The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behaviour in rats. For example, relaxin-3-positive projections and RXFP3 are present within hypothalamic feeding ci...
Potential hypothalamic targets of relaxin-3 innervation: a perspective [0.03%]
Relaxin-3神经支配的潜在下丘脑靶点：一种视角
Craig M Smith,Berenice E Chua,Andrew W Walker et al.
Craig M Smith et al.
Relaxin-3 is a recently identified neuropeptide transmitter primarily expressed by neurons of the pontine nucleus incertus, which binds/activates the G(i/o)-protein coupled receptor, RXFP3. Functional studies have demonstrated that relaxin-...
Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice [0.03%]
脑病毒传递的RXFP3激动剂促进小鼠觉醒
Craig M Smith,Anna Blasiak,Despina E Ganella et al.
Craig M Smith et al.
Anatomical and functional studies of central relaxin-3/RXFP3 systems suggest they constitute an ascending arousal network. For example, relaxin-3 knockout mice display circadian hypoactivity compared to wild type littermate controls. In stu...
Consequences of relaxin-3 null mutation in mice on food-entrainable arousal [0.03%]
放松素-3基因敲除小鼠的进食调控觉醒功能缺陷
Ihaia T Hosken,Craig M Smith,Berenice E Chua et al.
Ihaia T Hosken et al.
Relaxin-3/RXFP3 networks have been hypothesised to influence behavioural state based on their anatomical distribution and recent experimental findings in rat and mouse. Two arousal-related behaviours altered by changes in relaxin-3/RXFP3 si...
Plasma insulin-like factor 3 (INSL3) in male patients with osteoporosis and Klinefelter's syndrome [0.03%]
男性骨质疏松症和克兰费尔特综合征患者的血浆胰岛素样因子3(INSL3)水平研究
Andleeb Hussain,Ramasamyiyer Swaminathan,Arun Sankaralingam et al.
Andleeb Hussain et al.
Insulin-like factor 3 (INSL3) is a peptide hormone produced in leydig cells of the testes. Its role in the adult male is unknown but INSL3 and its receptor RXFP2 have been linked to bone cell differentiation. It is speculated that low level...