The TGF-beta1/upstream stimulatory factor-regulated PAI-1 gene: potential involvement and a therapeutic target in Alzheimer's disease [0.03%]
TGF-β1/USF调节的PAI-1基因：在阿尔茨海默病中可能的作用及治疗靶点
Paul J Higgins
Paul J Higgins
Amyloid peptide (A beta) aggregates, derived from initial beta-site proteolytic processing of the amyloid precursor protein (APP), accumulate in the brains of Alzheimer's disease patients. The plasmin-generating cascade appears to serve a p...
Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease [0.03%]
氧化损伤、蛋白质合成和降解在阿尔茨海默病中的相互作用
Jeffrey N Keller
Jeffrey N Keller
Protein synthesis and protein degradation are highly regulated cellular processes that are essential to maintaining cell viability. Numerous studies now indicate that protein synthesis and protein degradation are significantly altered in Al...
Determination of DNA damage in floriculturists exposed to mixtures of pesticides [0.03%]
接触混合农药的花卉工作者DNA损伤检测
J Castillo-Cadena,L E Tenorio-Vieyra,A I Quintana-Carabia et al.
J Castillo-Cadena et al.
The aim of the study was to determine possible DNA damage in floriculturists chronically exposed to pesticides. Leukocytes from 52 workers, 46 environmentally exposed, and 38 control individuals were evaluated with the comet assay. Serum fr...
Neutrophil secretion induced by an intracellular Ca2+ rise and followed by whole-cell patch-clamp recordings occurs without any selective mobilization of different granule populations [0.03%]
全细胞膜片钳记录诱导的中性粒细胞分泌并非由特定调动不同颗粒群导致
Daniel Granfeldt,Olle Harbecke,Ase Björstad et al.
Daniel Granfeldt et al.
We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in membrane capacitance (deltaC(m)). Both th...
Angela Torres,Juan J Nieto
Angela Torres
The purpose of this paper is to present a general view of the current applications of fuzzy logic in medicine and bioinformatics. We particularly review the medical literature using fuzzy logic. We then recall the geometrical interpretation...
Apocynin derivatives interrupt intracellular signaling resulting in decreased migration in breast cancer cells [0.03%]
阿朴菲衍生物通过干扰乳腺癌细胞内的信号转导来抑制其迁移能力
Robert F Klees,Paul C De Marco,Roman M Salasznyk et al.
Robert F Klees et al.
Cancer cells are defined by their ability to divide uncontrollably and metastasize to secondary sites in the body. Consequently, tumor cell migration represents a promising target for anticancer drug development. Using our high-throughput c...
Site-directed mutagenesis to assess the binding capacity of class s protein of Staphylococcus aureus leucotoxins to the surface of polymorphonuclear cells [0.03%]
定点诱变评估金黄色葡萄球菌白细胞毒素类S蛋白与多形核细胞表面结合的能力
L Baba Moussa,S Werner,M Coraiola et al.
L Baba Moussa et al.
Staphylococcal leucotoxins result from the association of class S components and class F component inducing the activation and the permeabilization of the target cells. Like alpha-toxin, the leucotoxins are pore-forming toxins with more tha...
Cloning and expression of human membrane-bound and soluble engineered T cell receptors for immunotherapy [0.03%]
人膜结合型和可溶工程化T细胞受体的克隆与表达用于免疫治疗
Nehad M Alajez,Saman Eghtesad,Olivera J Finn
Nehad M Alajez
We report here the design and construction of several gene vectors for expression in mammalian cells of membrane-bound and soluble human T cell receptors (TR). We designed a vector (TR-ALPHA-IRES-TR-BETA pEF4) that encodes high-level expres...
Víctor P García,F Valdés,R Martín et al.
Víctor P García et al.
A simple, rapid, and reliable TLC method for the separation and determination of sanguinarine has been established. This intensively studied biologically active alkaloid has a wide range of potentially useful medicinal properties, such as a...
Reduced atherosclerotic lesion size in P-selectin deficient apolipoprotein E-knockout mice fed a chow but not a fat diet [0.03%]
喂食常规食物而非高脂饮食的P-选择素缺陷型载脂蛋白E基因敲除小鼠动脉粥样斑块减小
Marie-Claude Bourdillon,Jacques Randon,Lydie Barek et al.
Marie-Claude Bourdillon et al.
P-selectin. We investigated the role of P-selectin on the development of vascular lesions in an ApoE(-/-) male mice. Double-knockout (ApoE(-/-), P-selectin(-/-); DKO) were compared to single-knockout (ApoE(-/-); SKO) mice. They were fed a c...