Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease [0.03%]
信号转导、泛素化、转运和包涵体：sequestosome 1/p62在神经退行性疾病中的作用
Marie W Wooten,Xiao Hu,J Ramesh Babu et al.
Marie W Wooten et al.
Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated prot...
Deng-Shun Wang,Dennis W Dickson,James S Malter
Deng-Shun Wang
Extensive beta-amyloid (A beta) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer's disease (AD). The mechanisms underlying A beta depos...
Mark A Smith,George Perry,Xiongwei Zhu et al.
Mark A Smith et al.
Targeting gonadotropins: an alternative option for Alzheimer disease treatment [0.03%]
靶向促性腺激素：阿尔茨海默病治疗的另一种选择
Gemma Casadesus,Emma Ramiro Puig,Kate M Webber et al.
Gemma Casadesus et al.
Recent evidence indicates that, alongside oxidative stress, dysregulation of the cell cycle in neurons susceptible to degeneration in Alzheimer disease may play a crucial role in the initiation of the disease. As such, the role of reproduct...
The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits [0.03%]
与阿尔茨海默病相关的 creatine kinase/creatine 联系：CK 失活、APP-CK 复合体和局部 creatine 沉积点
Tanja S Bürklen,Uwe Schlattner,Ramin Homayouni et al.
Tanja S Bürklen et al.
Cytosolic brain-type creatine kinase (BB-CK), which is coexpressed with ubiquitous mitochondrial uMtCK, is significantly inactivated by oxidation, in Alzheimer's disease (AD) patients. Since CK has been shown to play a fundamental role in c...
Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target [0.03%]
阿尔茨海默病中蛋白磷酸化/去磷酸化的失调：一个治疗靶点
Cheng-Xin Gong,Fei Liu,Inge Grundke-Iqbal et al.
Cheng-Xin Gong et al.
Studies during the last two decades have provided new insights into the molecular mechanism of Alzheimer's disease (AD). One of the milestone findings in AD research was the demonstration that neurofibrillary degeneration characterized by t...
Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics [0.03%]
衰老和阿尔茨海默病中的线粒体氧化损伤及靶向线粒体抗氧化治疗的潜在意义
P Hemachandra Reddy
P Hemachandra Reddy
The overall aim of this article is to review current therapeutic strategies for treating AD, with a focus on mitochondrially targeted antioxidant treatments. Recent advances in molecular, cellular, and animal model studies of AD have reveal...
Parkinson's disease in relation to pesticide exposure and nuclear encoded mitochondrial complex I gene variants [0.03%]
帕金森病与农药接触和线粒体复合物I核编码基因变异的关系
Elizabeth H Corder,George D Mellick
Elizabeth H Corder
Parkinson's disease (PD) is a common age-related neurodegenerative disorder thought to result from the integrated effects of genetic background and exposure to neuronal toxins. Certain individual nuclear-encoded mitochondrial complex I gene...
Heme deficiency in Alzheimer's disease: a possible connection to porphyria [0.03%]
阿尔茨海默病的血红素缺乏：与紫质病可能存在的联系
Barney E Dwyer,Meghan L Stone,Xiongwei Zhu et al.
Barney E Dwyer et al.
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD pathogenesis. If true, factors that contribute to ...
Atsushi Takeda,Takafumi Hasegawa,Michiko Matsuzaki-Kobayashi et al.
Atsushi Takeda et al.
alpha-synuclein is a key molecule in the pathogenesis of synucleinopathy including Parkinson's disease and multiple system atrophy. In this mini-review, we mainly focus on recent data obtained from cellular models of synucleinopathy and dis...