Shi-Lung Lin,Joseph D Miller,Shao-Yao Ying
Shi-Lung Lin
Nearly 97% of the human genome is composed of noncoding DNA, which varies from one species to another. Changes in these sequences often manifest themselves in clinical and circumstantial malfunction. Numerous genes in these non-protein-codi...
Molecular basis for the immunostimulatory potency of small interfering RNAs [0.03%]
关于小分子干扰RNA免疫刺激作用的分子机制研究
Mouldy Sioud,Gro Furset
Mouldy Sioud
Small interfering RNAs (siRNAs) represent a new class of antigene agents, which has emerged as a powerful tool for functional genomics and might serve as a potent therapeutic approach. However, several studies have showed that they could tr...
Transplacental RNAi: deciphering gene function in the postimplantation-staged embryo [0.03%]
穿越胎盘的RNA干扰：解读植入后阶段胚胎中的基因功能
K Sue O&#x;shea,Lisa S De Boer,Nicole A Slawny et al.
K Sue O&#x;shea et al.
RNAi offers the opportunity to examine the role in postimplantation development of genes that cause preimplantation lethality and to create allelic series of targeted embryos. We have delivered constituitively expressed short hairpin (sh) R...
Hypothesis: a role for fragile X mental retardation protein in mediating and relieving microRNA-guided translational repression? [0.03%]
假说：脆性X染色体智力低下的蛋白质在介导和解除微小RNArnaA guided翻译抑制方面发挥作用？
Isabelle Plante,Patrick Provost
Isabelle Plante
MicroRNA (miRNA)-guided messenger RNA (mRNA) translational repression is believed to be mediated by effector miRNA-containing ribonucleoprotein (miRNP) complexes harboring fragile X mental retardation protein (FMRP). Recent studies document...
Akihiko Nunomura,Kazuhiro Honda,Atsushi Takeda et al.
Akihiko Nunomura et al.
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion disease, subacute sclerosing panencephalit...
Kathleen S Hruska,Ozlem Goker-Alpan,Ellen Sidransky
Kathleen S Hruska
Several recent observations suggest a connection between Gaucher disease, the inherited deficiency of glucocerebrosidase, and the synucleinopathies. Rare patients have been observed who develop both Gaucher disease and parkinsonism. Autopsy...
J Avila,I Santa-María,M Pérez et al.
J Avila et al.
Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation th...
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease [0.03%]
胆固醇和脂质在阿尔茨海默病发生发展中的作用
Leonel Rojo,Marcela K Sjöberg,Paula Hernández et al.
Leonel Rojo et al.
Alzheimer's disease is the principal cause of dementia throughout the world and the fourth cause of death in developed economies.This brain disorder is characterized by the formation of brain protein aggregates, namely, the paired helical f...
John D Doherty
John D Doherty
Pesticides are routinely screened in studies that follow specific guidelines for possible neuropathogenicity in laboratory animals. These tests will detect chemicals that are by themselves strong inducers of neuropathogenesis if the tested ...
David R Wallace
David R Wallace
Individuals suffering from human immunodeficiency virus type 1 (HIV-1) infection suffer from a wide range of neurological deficits. The most pronounced are the motor and cognitive deficits observed in many patients in the latter stages of H...