Distinction between pore assembly by staphylococcal alpha-toxin versus leukotoxins [0.03%]
表皮葡萄球菌α-毒素与白细胞毒素形成孔道的区别
Olivier Joubert,Joëlle Voegelin,Valérie Guillet et al.
Olivier Joubert et al.
The staphylococcal bipartite leukotoxins and the homoheptameric alpha-toxin belong to the same family of beta-barrel pore-forming toxins despite slight differences. In the alpha-toxin pore, the N-terminal extremity of each protomer interact...
6A3-5/Osa2 is an early activated gene implicated in the control of vascular smooth muscle cell functions [0.03%]
6A3-5/Osa2是早期活化的基因并参与血管平滑肌细胞功能的调控
Gwenaele Garin,Kazem Zibara,Frederick Aguilar et al.
Gwenaele Garin et al.
Vascular smooth muscle cells (VSMC) growth plays a key role in the pathophysiology of vascular diseases. However, the molecular mechanisms controlling gene transcription in VSMC remain poorly understood. We previously identified, by differe...
Cellular prion protein and caveolin-1 interaction in a neuronal cell line precedes Fyn/Erk 1/2 signal transduction [0.03%]
细胞系中细胞内痒毒蛋白和腔素-1的相互作用发生在Fyn/Erk 1/2信号转导之前
Mattia Toni,Enzo Spisni,Cristiana Griffoni et al.
Mattia Toni et al.
It has been reported that cellular prion protein (PrPc) is enriched in caveolae or caveolae-like domains with caveolin-1 (Cav-1) participating to signal transduction events by Fyn kinase recruitment. By using the Glutathione-S-transferase (...
Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers [0.03%]
以基因为中心的整体基因表达谱分析方法的研究——以人类肺癌为例
Yuchun Guo,Gabriel S Eichler,Ying Feng et al.
Yuchun Guo et al.
Genome-wide gene expression profile studies encompass increasingly large number of samples, posing a challenge to their presentation and interpretation without losing the notion that each transcriptome constitutes a complex biological entit...
Specific immunoassays for placental alkaline phosphatase as a tumor marker [0.03%]
特异性的胎盘型碱性磷酸酶肿瘤标志物免疫测定法
Sérvio T Stinghen,Juliana F Moura,Patrícia Zancanella et al.
Sérvio T Stinghen et al.
Human placental (hPLAP) and germ cell (PLAP-like) alkaline phosphatases are polymorphic and heat-stable enzymes. This study was designed to develop specific immunoassays for quantifying hPLAP and PLAP-like enzyme activity (EA) in sera of ca...
Mette Ebbesen,Thomas G Jensen
Mette Ebbesen
Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on what is known as nanomedicine, referring t...
The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system [0.03%]
脂肪组织肾素血管紧张素系统调节全身胰岛素敏感性标志物并激活肾脏内的肾素血管紧张素系统
Suyeon Kim,Morvarid Soltani-Bejnood,Annie Quignard-Boulange et al.
Suyeon Kim et al.
Background: The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. ...
Frank Jacobsen,Janine Mertens-Rill,Juergen Beller et al.
Frank Jacobsen et al.
Background: Transfection efficacy after nonviral gene transfer in primary epithelial cells is limited. The aim of this study was to compare transfection efficacy of the recently available method of nucleofection with the ...
Computational prediction of microRNAs encoded in viral and other genomes [0.03%]
计算预测病毒及其他基因组中的微小RNA
Gard O S Thomassen,Oystein Røsok,Torbjørn Rognes
Gard O S Thomassen
We present an overview of selected computational methods for microRNA prediction. It is especially aimed at viral miRNA detection. As the number of microRNAs increases and the range of genomes encoding miRNAs expands, it seems that these sm...
RNA interference [0.03%]
RNA干扰技术
Mouldy Sioud,Abdelali Haoudi
Mouldy Sioud