Michael J Veness
Michael J Veness
Nonmelanoma skin cancers (squamous cell and basal cell carcinomas) occur at an epidemic rate in many countries with the worldwide incidence increasing. The sun-exposed head and neck are the most frequent sites for these cancers to arise and...
Regulation of defense responses against protozoan infection by interleukin-27 and related cytokines [0.03%]
细胞因子IL-27和相关细胞因子调节原生动物感染的免疫防御作用
Hiroki Yoshida,Yoshiyuki Miyazaki,Sen Wang et al.
Hiroki Yoshida et al.
Cytokine-mediated immunity is crucial in the defense against pathogens. Recently, IL-23 and IL-27 were identified, which along with IL-12 belong to the IL-12 cytokine family. IL-27 is pivotal for the induction of helper T cell (Th) 1 respon...
Tetrasomy 15q11-q13 diagnosed by FISH in a patient with autistic disorder [0.03%]
应用FISH技术诊断的孤独症患者15q11-q13区四体性
Karim Ouldim,Abdelhafid Natiq,Philippe Jonveaux et al.
Karim Ouldim et al.
We report the case of a Moroccan boy with mental retardation, hyperactivity, epilepsy, developmental problems and behavioural disorders. Cytogenetic analysis showed the presence of a supernumerary marker chromosome. Molecular cytogenetics a...
Mustapha Chamekh
Mustapha Chamekh
Activation of the immune system against protozoan infections relies particularly on two specific signals provided by cognate interaction of T cells with antigen presenting cells (APCs). The first signal is attributed to binding of the T-cel...
Role of p53 and CDKN2A inactivation in human squamous cell carcinomas [0.03%]
人鳞状细胞癌中p53和CDKN2A失活的作用
Alessia Pacifico,Giovanni Leone
Alessia Pacifico
p53 tumor suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Inactivation of CDKN2A can lead to deregulation of these two pa...
The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells [0.03%]
SDF-1α、CXCR4激动剂及拮抗剂对造血祖细胞的多种作用
Anne Faber,Christoph Roderburg,Frederik Wein et al.
Anne Faber et al.
Stromal cell-derived factor-1alpha (SDF-1alpha) has pleiotropic effects on hematopoietic progenitor cells (HPCs). We have monitored podia formation, migration, proliferation, and cell-cell adhesion of human HPC under the influence of SDF-1a...
PAI-1 is a Critical Upstream Regulator of the TGF-beta1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma [0.03%]
突变型p53人类皮肤鳞状细胞癌中PAI-1是TGF-β1/EGF诱导的侵袭表型的关键上游调节因子
Cynthia E Wilkins-Port,Craig E Higgins,Jennifer Freytag et al.
Cynthia E Wilkins-Port et al.
The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-beta synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-beta/EGF...
Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population [0.03%]
Moroccan人群同型半胱氨酸和体温不稳定型亚甲基四氢叶酸还原酶C677T多态性为冠状动脉疾病的危险因素
Nawal Bennouar,Abdellatif Allami,Houssine Azeddoug et al.
Nawal Bennouar et al.
Increased plasma total homocysteine (tHcy) levels have been shown to be a risk factor for coronary artery disease (CAD). The common methylenetetrahydrofolate reductase C677T (MTHFR C677T) polymorphism has been reported to be a strong predic...
Impact of lactic Acid bacteria on dendritic cells from allergic patients in an experimental model of intestinal epithelium [0.03%]
乳酸菌对肠道上皮实验模型中过敏患者树突状细胞的影响
Céline Ratajczak,Catherine Duez,Corinne Grangette et al.
Céline Ratajczak et al.
Lactic acid bacteria (LAB) are Gram positive nonpathogenic commensal organisms present in human gastrointestinal tract. In vivo, LAB are separated from antigen-presenting cells such as dendritic cells (DC) by the intestinal epithelial barri...
Expression by streptomyces lividans of the rat alpha integrin CD11b A-domain as a secreted and soluble recombinant protein [0.03%]
灰色链霉菌分泌表达可溶型大鼠α整合素CD11b凝集素结构域蛋白
Dorra Zouari Ayadi,Hichem Chouayekh,Sonda Mhiri et al.
Dorra Zouari Ayadi et al.
We already reported the use of a long synthetic signal peptide (LSSP) to secrete the Streptomyces sp. TO1 amylase by Streptomyces lividans strain. We herein report the expression and secretion of the rat CD11b A-domain using the same LSSP a...