Evidence of a genomic biomarker in normal human epithelial mammary cell line, MCF-10A, that is absent in the human breast cancer cell line, MCF-7 [0.03%]
证据表明，在人类乳腺癌细胞系MCF-7中缺失的基因组生物标志物存在于正常的人类上皮性乳腺细胞系MCF-10A中
Brian H Crawford,A K M A Hussain,Nathan M Jideama
Brian H Crawford
This study investigated the use of DNA amplification fingerprinting (DAF) to identify biomarkers useful in the elucidating genetic factors that lead to carcinogenesis. The DNA amplification fingerprinting (DAF) technique was used to generat...
Jonathan R Latham,Allison K Wilson,Ricarda A Steinbrecher
Jonathan R Latham
Plant transformation is a genetic engineering tool for introducing transgenes into plant genomes. It is now being used for the breeding of commercial crops. A central feature of transformation is insertion of the transgene into plant chromo...
Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases [0.03%]
组蛋白去乙酰酶在癌症和寄生虫病中的药物靶点潜力研究进展
Mehdi Ouaissi,Ali Ouaissi
Mehdi Ouaissi
The elucidation of the mechanisms of transcriptional activation and repression in eukaryotic cells has shed light on the important role of acetylation-deacetylation of histones mediated by histone acetyltransferases (HATs) and histone deace...
Wolfgang A Schulz
Wolfgang A Schulz
Retrotransposons like L1 are silenced in somatic cells by a variety of mechanisms acting at different levels. Protective mechanisms include DNA methylation and packaging into inactive chromatin to suppress transcription and prevent recombin...
The genomic distribution of L1 elements: the role of insertion bias and natural selection [0.03%]
L1元件的基因组分布规律：兼论插入偏好和自然选择的作用
Todd Graham,Stephane Boissinot
Todd Graham
LINE-1 (L1) retrotransposons constitute the most successful family of retroelements in mammals and account for as much as 20% of mammalian DNA. L1 elements can be found in all genomic regions but they are far more abundant in AT-rich, gene-...
L1 antisense promoter drives tissue-specific transcription of human genes [0.03%]
L1反向 promoters驱动人类基因的组织特异性转录
Kert Mätlik,Kaja Redik,Mart Speek
Kert Mätlik
Transcription of transposable elements interspersed in the genome is controlled by complex interactions between their regulatory elements and host factors. However, the same regulatory elements may be occasionally used for the transcription...
Mary F Lyon
Mary F Lyon
There is longstanding evidence that X-chromosome inactivation (XCI) travels less successfully in autosomal than in X-chromosomal chromatin. The interspersed repeat elements LINE1s (L1s) have been suggested as candidates for "boosters" which...
LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease: mutation detection bias and multiple mechanisms of target gene disruption [0.03%]
由LINE-1内切酶介导的转座事件导致的人类遗传疾病：突变检测偏差和靶基因破坏的多种机制
Jian-Min Chen,Claude Férec,David N Cooper
Jian-Min Chen
LINE-1 (L1) elements are the most abundant autonomous non-LTR retrotransposons in the human genome. Having recently performed a meta-analysis of L1 endonuclease-mediated retrotranspositional events causing human genetic disease, we have ext...
The ORF1 protein encoded by LINE-1: structure and function during L1 retrotransposition [0.03%]
LINE-1编码的ORF1蛋白：在L1逆转录转座过程中的结构与功能
Sandra L Martin
Sandra L Martin
LINE-1 or L1 is an autonomous non-LTR retrotransposon in mammals. Retrotransposition requires the function of the two L1-encoded polypeptides, ORF1p and ORF2p. Early recognition of regions of homology between the predicted amino acid sequen...
Evan A Farkash,Eline T Luning Prak
Evan A Farkash
Barbara McClintock was the first to suggest that transposons are a source of genome instability and that genotoxic stress assisted in their mobilization. The generation of double-stranded DNA breaks (DSBs) is a severe form of genotoxic stre...