Bruton's Tyrosine Kinase: Pathophysiological Roles and Inhibitor-Based Therapeutic Advances [0.03%]
布鲁顿酪氨酸激酶的病理生理作用及抑制剂治疗进展
Simhadri Goud Gundrathi,Bharat Kumar Reddy Sanapalli,Shrestha Palit et al.
Simhadri Goud Gundrathi et al.
Bruton's tyrosine kinase (BTK) plays a pivotal role in intracellular signaling within B-cells, governing development, differentiation, and survival, and is an integral target in treating B-cell malignancies and autoimmune disorders. The imp...
Functional Characterization of TMEM63 in Cochlear Hair Cells Reveals a Role in Calcium Signaling, Proliferation, Apoptosis, and Migration [0.03%]
TMEM63在耳蜗毛细胞中的功能表征揭示了其在钙信号传导、增殖、凋亡和迁移中的作用
Peng Wang,Jiankang Huang,Pengyu Ding et al.
Peng Wang et al.
TMEM63 is a mechanosensitive transmembrane protein implicated in calcium regulation; however, its specific function in cochlear auditory cells remains undefined. Calcium signaling is essential for cochlear hair cell proliferation, apoptosis...
Alpha Lipoic Acid Promotes the Proliferation, Motility, and Antioxidant Defense System of Human Adipose-Derived Stromal/Stem Cells [0.03%]
α-生育酚促进人脂肪来源stromal/stem细胞的增殖、运动和抗氧化防御系统
Gizem Uslu,Zehra Seda Halbutoğulları
Gizem Uslu
Adipose-derived stromal/stem cells (ASCs) are a readily accessible mesenchymal stem cell population with high regenerative and immunomodulatory potential. Despite their regenerative potential, ASCs experience replicative senescence during i...
Targeting Estrogen Pathways in Breast Cancer: A Review of Current Therapies and Emerging Strategies [0.03%]
乳腺癌中靶向雌激素途径的治疗：现有疗法与新兴策略概述
Maitri Dabhi,Ishvarchandra Parmar,Chandrakant Bonde
Maitri Dabhi
Breast cancer continues to be the most commonly diagnosed cancer among women worldwide, with estrogen receptor-positive (ER +) types making up the largest portion. At the heart of this subtype is the estrogen signaling pathway, especially t...
Multifunctional Collagen-Like Protein as a Gene Therapy Vehicle for Biomedical Applications [0.03%]
多功能类胶原蛋白作为生物医学应用的基因治疗载体
Gopalan Akilandeswari,Niraikulam Ayyadurai
Gopalan Akilandeswari
Gene therapy, utilizing a protein-based delivery system, offers a promising alternative to viral vectors owing to their stability, cell specificity, and adaptability. This study investigates the potential of collagen, a key extracellular ma...
Venous Endothelial Cells Promote Osteoblast Differentiation More Effectively Than Arterial Cells via TGF-β/BMP9 and Notch Pathway-Related Gene Expression [0.03%]
静脉内皮细胞通过TGF-β / BMP9和Notch信号相关基因表达比动脉内皮细胞更有效地促进成骨细胞分化
Célio J C Fernandes,Rodrigo A Foganholi da Silva,Marcel R Ferreira et al.
Célio J C Fernandes et al.
The coupling between angiogenesis and osteogenesis is a key determinant of skeletal homeostasis, yet the influence of endothelial cell origin on osteoblast differentiation remains underexplored. Here, we investigated how venous (HUVECs) and...
Mapping Three Decades of Rho GTPase Signalling in Cancer: Unveiling Loopholes and Future Directions (1990-2024) [0.03%]
绘制癌症中Rho GTP酶信号转导30年地图：揭示漏洞和未来方向（1990-2024）
Nik Yasmin Umaira Hasnizan,Chien Fung Chong,Ana Masara Ahmad Mokhtar
Nik Yasmin Umaira Hasnizan
Rho GTPases, including RhoA, Rac1, and Cdc42, are central regulators of cytoskeletal dynamics, cell migration, proliferation, and survival, and their dysregulation is firmly implicated in cancer initiation and progression. Although extensiv...
Renin Inhibition and eNOS Upregulation as Novel Mechanisms of Antihypertensive Food Peptides [0.03%]
新型降血压肽通过抑制肾素和上调eNOS机制发挥作用
Tolulope Joshua Ashaolu
Tolulope Joshua Ashaolu
Food-derived bioactive peptides are gaining significant attention as safer, natural alternatives to synthetic drugs for managing hypertension. While research has predominantly focused on angiotensin-converting enzyme (ACE) inhibition, the f...
Qualitative Comparison of LED and LASER Effects on Cutaneous Wound Healing: A Systematic Review of Experimental Studies [0.03%]
关于光疗对皮肤伤口愈合影响的系统评价：实验研究定性比较(LED与激光)
Mariana Bezerra Miranda,Ana Carolina Silva Barros,Rebeca Barbosa da Rocha et al.
Mariana Bezerra Miranda et al.
This systematic review presents qualitative comparisons between LED and LASER photobiomodulation in cutaneous wound healing, limited by the substantial heterogeneity of experimental parameters. Chronic wounds represent a major clinical chal...
Comparative Study
Cell biochemistry and function. 2026 Jan;44(1):e70161. DOI:10.1002/cbf.70161 2026
Morphological and Optical Characterization of NRAS-Mutant Melanoma Cells and Primary Melanocytes via Quantitative Phase Imaging With Digital Holographic Microscopy [0.03%]
基于数字全息显微技术的定量相位成像表征NRAS突变黑色素瘤细胞及原代黑色素细胞的形态学和光学参数
Ayah A Farhat,Yazan A Almahdi,Fatima Z Alshuhani et al.
Ayah A Farhat et al.
Early detection of melanoma, a highly variable and aggressive form of skin cancer, is crucial for improving patient outcomes. It is essential to distinguish malignant cells from normal melanocytes, and therefore, label-free imaging methods ...