Diabetes Mellitus and Malaria Co-Existence as Deadly Burden in Sub-Saharan Africa: A Review of Clinical Outcomes and Molecular Interactions [0.03%]
糖尿病和疟疾在撒哈拉以南非洲的共存关系：临床结局与分子相互作用综述
Osas Graham Erhabor,Aliyu Dantani Abdullahi,Abdullateef Sani et al.
Osas Graham Erhabor et al.
Diabetes and malaria co-morbidity in malaria-endemic areas has significant therapeutic implications. Evidence suggests that diabetes mellitus promotes malaria pathogenicity while malaria exposure is thought to modulate blood glucose and ins...
Advancing Cancer Management: The Dual Diagnostic-Prognostic Potential of Nucleic Acid Biomarkers [0.03%]
肿瘤的诊疗进步——核酸标志物诊断和预后的双重潜力
Yongle Shao,Qinpeng Jin,Jiaying Zhang et al.
Yongle Shao et al.
Cancer is a global health issue with a high mortality rate, and early detection significantly improves patient survival rates. Currently, the primary methods for cancer detection include imaging examination and tissue biopsy. However, due t...
The MDM2-IL-33 Axis Promotes Gastric Tumorigenesis via K63 Ubiquitination-Dependent ERK/JNK Activation [0.03%]
MDM2-IL-33轴通过K63泛素化依赖的ERK / JNK活化促进胃肿瘤发生
Ning Huang,Xiaoling Zan,Liqing Liu et al.
Ning Huang et al.
This study uncovers a novel post-translational regulatory mechanism through which MDM2 stabilizes IL-33 via K63-linked ubiquitination, thus facilitating the progression of gastric cancer. Using MKN45 and AGS gastric cancer cells, we conduct...
Synergistic Antitumor Potential of Propolis With 6‑Mercaptopurine and 5‑Fluorouracil [0.03%]
巴西绿胡蜂胶与巯嘌呤和氟尿嘧啶的协同抗肿瘤潜力研究
Abdullah Ahmed A Majami,Ehab M M Ali,Abdulaziz A Kalantan et al.
Abdullah Ahmed A Majami et al.
6-MP and 5-FU are effective anticancer drugs; still, their efficacy is limited by inadequate solubility and dose-dependent toxicity. Propolis, high in bioactive chemicals, was investigated for its synergistic effects to improve efficacy. GC...
Characterization, Antimicrobial, and Antiproliferative Activities of Silver Nanoparticles Biosynthesized Using Terminalia phanerophlebia Engl. & Diels [0.03%]
Terminalia phanerophlebia Engl. & Diels制备的银纳米颗粒的表征及其抗菌和抗增殖活性
Folasade O Banji-Onisile,Nneka A Akwu,Tosin A Olasehinde et al.
Folasade O Banji-Onisile et al.
The application of nanoparticles (NPs) as therapeutic strategies for treating microbial infections and cancer is gaining attention due to their physicochemical properties. In this study, we synthesized silver nanoparticles (AgNPs) from the ...
Ameliorative Role of Phoenix dactylifera Seeds Against Cadmium-Induced Ovarian Toxicity in Rats: The Role of Low-Dose Gamma Radiation [0.03%]
无花果种子改善镉致大鼠卵巢毒性作用及低剂量γ射线的作用机制
Azza E Kayed,Nermeen M Elbakary,Sanaa A Hagag et al.
Azza E Kayed et al.
Cadmium exposure is a known disruptor of ovarian redox homeostasis and steroidogenesis, with clinically relevant implications for fertility and pregnancy outcomes. We hypothesized that date seed extract (DS), rich in antioxidant constituent...
New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases [0.03%]
热休克蛋白作为各种应激源下活性氧调节者的最新见解在疾病中的作用
Paka Sravan Kumar,Triveni Kodi,Adarsh Gopinathan et al.
Paka Sravan Kumar et al.
Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stre...
The Perspectives of Posttranslational Modifications of Nuclear Proteins in Related Physiology and Diseases Assisted With Multi-Omics Integrative Analysis and Machine Learning [0.03%]
多组学整合分析和机器学习辅助的核内蛋白质翻译后修饰的功能与疾病研究展望
Qianyu Tang,Linzhi Wang,Nian Fu et al.
Qianyu Tang et al.
Many epigenetic drugs lack specificity, which may lead to drug resistance and long-term safety concerns. There is an urgent need to develop more precise nuclear-targeted drugs to reduce adverse reactions and harmful effects. The development...
Serum SIRT1 Levels and Gene Polymorphisms in Breast Cancer: A Biomarker and Genetic Association Study [0.03%]
乳腺癌中的血清SIRT1水平和基因多态性：生物标志物及遗传相关研究
Desy Thayyil Menambath,Usha Adiga,Vijith Shetty et al.
Desy Thayyil Menambath et al.
Silent mating type information regulation 2 homolog (SIRT1), a key protein involved in cellular regulation, exhibits altered expression in breast cancer. The study aimed to assess serum Sirtuin 1 level, investigate SIRT1 gene polymorphisms,...
ALDH2 and NFκB Activation Restores VEGFR2 Expression and Angiogenesis Impaired by 4-HNE in Coronary Endothelial Cells [0.03%]
4-羟基壬烯醛通过激活NFκB抑制冠状动脉内皮细胞VEGFR2表达和诱导血管生成免疫耐受的作用及ALDH2和NFκB干预的改善作用研究
Bipradas Roy,Emmanuel Oppong Yeboah,Rajarajan Amirthalingam Thandavarayan et al.
Bipradas Roy et al.
4-hydroxy-2-nonenal (4HNE), a reactive aldehyde produced during lipid peroxidation, reduces angiogenesis in cultured mouse coronary endothelial cells (MCECs). In our previous studies, we found that 4HNE lowers both mRNA and protein levels o...