From Redox Imbalance to Tissue Injury: Insights Into Antidepressant Drug Amitriptyline Effects on Salivary Glands [0.03%]
从氧化还原失衡到组织损伤：胺三环类抗抑郁药物阿米替林对唾液腺影响的新见解
Cristian Dos Santos Pereira,Deiweson Souza-Monteiro,Yago Gecy de Sousa Né et al.
Cristian Dos Santos Pereira et al.
This study aimed to investigate the effects of amitriptyline administration on the salivary glands and saliva of rats. Twenty-eight male Wistar rats (60 days old) were divided into two groups (n = 14 per group): control and amitriptyline-tr...
Therapeutic Efficacy of S-Allyl-L-Cysteine an Active Constituent of Aged Garlic Extract in Rat Model of Gestational Diabetes Mellitus [0.03%]
S-烯丙基-L半胱氨酸改善妊娠期糖尿病大鼠胰岛素抵抗及胎盘氧化应激损伤的作用及机制研究
Jingjing Wang,Liming Ma,Xiaofeng Yan et al.
Jingjing Wang et al.
Gestational diabetes mellitus (GDM) is a major pregnancy complication that adversely affects fetal development. Emerging evidence implicates inflammation and oxidative stress in its pathogenesis, highlighting the need for in-depth mechanist...
Neutrophils in Coronavirus Disease 2019: Guardians or Triggers of Immunopathology? [0.03%]
中性粒细胞在新型冠状病毒疾病2019：免疫病理的守护者还是触发者？
Fatemeh Mohammadi Henjeroei,Niloufar Nosratabadi,Hossein Pourghadamyari et al.
Fatemeh Mohammadi Henjeroei et al.
COVID-19 (coronavirus disease 2019) is a respiratory viral disease with a wide range of clinical symptoms that emerged in December 2019. Innate immunity serves as a rapid immune system that can fight off pathogens before they can spread and...
Adipose Tissue Extracellular Matrix Remodeling: A Driver of Obesity and Insulin Resistance [0.03%]
脂肪组织细胞外基质重塑：肥胖和胰岛素抵抗的驱动因素
Imane Nait Irahal,Asmaa Chbel,Ayoub Lafnoune et al.
Imane Nait Irahal et al.
This review explores the role of extracellular matrix (ECM) in adipose tissue highlighting its composition, regulation, and impact on obesity and insulin resistance. The ECM in adipocytes is a dynamic entity and highly organized network com...
Irisin, Sclerostin, and Inflammatory Axis: Implication in Bone-Muscle Wasting Diseases [0.03%]
irisin、sclerostin与炎症轴在骨肌消耗性疾病中的作用
Mohamad Maged,Sameh Heikal,Salma Ibrahim et al.
Mohamad Maged et al.
Bone-muscle diseases, such as osteoporosis, rheumatoid arthritis, sarcopenia and cachexia, represent a growing global health concern, particularly among aging populations and older adults. These multifactorial disorders are characterized by...
Inhibition of the Apelin/APJ Axis Modulates Type 1 Cytotoxic T Cell and Type 2 Cytotoxic T-Related Immune Responses in an Animal Model of Metastatic Breast Cancer [0.03%]
阿佩林/APJ轴抑制调节1型细胞毒性T细胞和2型细胞毒性T相关免疫反应在转移性乳腺癌动物模型中的作用机制研究
Tayyebeh Tavakoli,Raziyeh Zandvakili,Javad Masoumi et al.
Tayyebeh Tavakoli et al.
Apelin, an adipose-derived peptide, is overexpressed in the microenvironment of various tumors, modulating anti-tumor immune responses. In the immune system, cytotoxic T cells perform a fundamental role in cancerous cell elimination. Theref...
Synergistic Effects of Caffeine and Paclitaxel in Breast Cancer Cells: Mechanistic Insights Into NF-κB and Nrf2 Signaling [0.03%]
咖啡因和紫杉醇在乳腺癌细胞中的协同作用：NF-κB和Nrf2信号机制的见解
Hasan Gencoglu,Saime Delioglu,Mehmet Akif Nergiz et al.
Hasan Gencoglu et al.
Breast cancer remains one of the most prevalent malignancies among women. Recent studies have explored the potential of phytochemicals such as caffeine as chemosensitizing agents in enhancing the efficacy of standard chemotherapeutics like ...
Mechanisms and Targeted Therapeutic Strategies for Inflammation and Renal Fibrosis in Hyperuricemic Nephropathy [0.03%]
高尿酸血症肾病炎症和肾纤维化的机制及靶向治疗策略
Lei Xuan,Weiyu Yang,Xiran Luo et al.
Lei Xuan et al.
Hyperuricemia (HUA) is a growing global health issue driven by economic development and lifestyle changes. Approximately 75% of uric acid in humans is excreted renally. Excess uric acid deposits in renal tissues, promoting tubulointerstitia...
Repositioning Propranolol for Neuroimmune Modulation: A Molecular Perspective on Glial Inflammation and Autophagy via Integrated In Vitro and Computational Approaches [0.03%]
β阻滞剂普萘洛尔的神经免疫调节再定位：整合体外和计算方法下的胶质细胞炎症与自噬分子机制研究
Dilara Nemutlu Samur
Dilara Nemutlu Samur
Propranolol, a non-selective β-blocker, exerts anti-inflammatory and neuroprotective effects beyond cardiovascular use. However, its role in autophagy remains unclear, despite the relevance of autophagy to neuroinflammatory conditions such...
Metabolomic Analysis of Metabolic Syndrome and Effects of Wharton's Jelly Mesenchymal Stem Cell Small Extracellular Vesicles Therapy in Rat Models Using Nuclear Magnetic Resonance Spectroscopy [0.03%]
核磁共振光谱代谢组学分析代谢综合征及Wharton胶原间充质干细胞小细胞外囊泡治疗效果的筛选模型 rats Screening of metabolic syndrome and effects of Wharton's jelly mesenchymal stem cell small extracellular vesicles therapy in rat models using nuclear magnetic resonance spectroscopy metabolomics analysis
Magdalene Tan Mei Ling,Illayaraja Krishnan,Kayatri Govindaraju et al.
Magdalene Tan Mei Ling et al.
Long-term management of metabolic syndrome (MetS) often involves polypharmacy, which may lead to undesirable outcomes. Regenerative approaches such as mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have gained attenti...