MMP9 Serves as a Prognostic Biomarker and Immune-Associated Regulator in Diffuse Large B-Cell Lymphoma [0.03%]
基质金属蛋白酶9在弥漫性大B细胞淋巴瘤中作为预后生物标志物和免疫调节因子的作用研究
JunXiu Liu,JiaQi Qin,XiaoJing Shi et al.
JunXiu Liu et al.
Matrix metalloproteinase 9 (MMP9) is a zinc-dependent endopeptidase involved in extracellular matrix (ECM) remodeling and inflammatory signaling. Although MMP9 has been implicated in tumor progression and immune modulation in solid tumors, ...
Camila S Freitas,Eduardo A F Coelho,Myron Christodoulides
Camila S Freitas
Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encom...
Autophagy, Apoptosis, and Inflammatory Mechanisms in Chronic Respiratory Diseases: Interplay in Special Reference to Mitochondrial-ER Stress Axis [0.03%]
慢性呼吸系统疾病中的自噬、凋亡和炎症机制：以线粒体-内质网应激轴互作为重点参考
Aditi Chitale,Smriti Verma,Madhav Nilakanth Mugale
Aditi Chitale
Chronic respiratory diseases (CRDs) such as asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer, along with other CRDs, continue to be a major cause of morbidity and mortality globally and constitut...
LncRNA H19: A Potential Diagnostic and Therapeutic Target for Kidney Diseases [0.03%]
长链非编码RNA H19：肾脏疾病的潜在诊断和治疗靶点
Hamza Malik Okuyan,Ayça Coskun,Şeyda Öznur Ayçiçek Özen et al.
Hamza Malik Okuyan et al.
Kidney diseases (KDs) impact over 800 million individuals globally, leading to significant morbidity and mortality. KDs place significant socioeconomic burdens on healthcare systems and lower patients' quality of life. Recent advancements a...
d-Pinitol Rescues Osteoblast Differentiation From Tumor Necrosis Factor-Alpha-Mediated Suppression via β-Galactoside α-2,6-Sialyltransferase 1 Induction [0.03%]
D-海因糖通过诱导β半乳糖苷α-2,6岩藻糖基转移酶1表达拯救肿瘤坏死因子α介导的成骨细胞分化抑制作用
Kyeong-Min Kim,Su-Jeong Kim,Won-Gu Jang
Kyeong-Min Kim
d-pinitol, a naturally occurring inositol derivative found in legumes and soy-based foods, has shown various biological effects, including anti-inflammatory and insulin-sensitizing activities. However, its role in osteoblast differentiation...
High Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment [0.03%]
高血糖通过线粒体功能障碍和线粒体自噬损伤诱导巨噬细胞衰老
Liying Tang,Xiuting Huang,Pei Li
Liying Tang
Chronic hyperglycemia accelerates immune aging and contributes to diabetic complications, yet the mitochondrial mechanisms responsible for macrophage senescence remain unclear. In this study, both cultured and primary macrophages were treat...
JOSD1 Deubiquitinates Twist1 and Facilitates Epithelial-Mesenchymal Transition in Glioblastoma [0.03%]
JOSD1通过去泛素化Twist1促进胶质母细胞瘤上皮间质转化
Jiaquan Song,Wenjin Qiu,Ruting Wei et al.
Jiaquan Song et al.
Glioblastoma (GBM) is a lethal brain tumor where diffuse invasion and a mesenchymal phenotype drive therapy resistance. Maintaining proteostasis through ubiquitin editing is a crucial stress-adaptive mechanism in cancer, but its role in GBM...
Anti-Inflammatory Effect of miR-197-3p-Loaded Microvesicles in Familial Mediterranean Fever Mouse Model [0.03%]
携带miR-197-3p的微泡在家族性地中海热小鼠模型中的抗炎作用
Yeliz Z Akkaya-Ulum,Emre Nalbant,Baris Ulum et al.
Yeliz Z Akkaya-Ulum et al.
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disease triggered by Mediterranean Fever (MEFV) gene mutations that lead to spontaneous pyrin inflammasome activation and exaggerated pro-inflammatory cytokine secretion. T...
Serum Sodium and Gut Klebsiella Are Positively Related to Osteoporosis [0.03%]
血清钠和肠道克雷伯氏菌与骨质疏松症呈正相关
Xiuhong Cao,Pengbing Hua,Yongjun Zhu et al.
Xiuhong Cao et al.
Emerging evidence suggests a link between gut microbiota dysbiosis and osteoporosis. However, specific bacterial taxa and metabolic correlates in human osteoporosis remain poorly characterized. This study explored gut microbial profiles and...
Sambuddha Sengupta,Ganesh Venkatraman
Sambuddha Sengupta
Drug resistance, also known as chemoresistance, is a known impediment in fighting cancers. Pak1 (p21-activated kinase), a serine/threonine kinase, is a known oncogene implicated in tumor progression and associated with poor prognosis in can...