Interpretation of Potential Interactions and Adverse Effects by Apigenin and Chrysin Based on Their Regulation of Metabolizers and Transporters in Mouse Embryonic Fibroblasts [0.03%]
基于鼠胚胎成纤维细胞中黄酮类化合物木犀草素和芹菜素对代谢酶和转运体调节作用的潜在相互作用及不良反应分析
Prasanth Puthanveetil
Prasanth Puthanveetil
Apigenin and chrysin are chemically close and related flavonoids. Our previous works have demonstrated both apigenin and chrysin's ability to reduce cholesterol and uric acid biosynthesis along with upregulation of ketone bodies and endogen...
Apigenin Enhances the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells Into Insulin-Producing Cells by Inducing Autophagy [0.03%]
阿皮金通过诱导自噬促进脂肪来源间充质干细胞向胰岛素产生细胞的分化
Mozafar Khazaei,Zeinab Shakibaee Fard,Maryam Bozorgi et al.
Mozafar Khazaei et al.
The present study aimed to evaluate the effect of apigenin (Api) on the differentiation of adipose tissue-derived mesenchymal stem cells (ASCs) into insulin-producing cells (IPCs) via inducing autophagy. ASCs were isolated from fresh adipos...
Synergistic Anticancer Effects of Akkermansia muciniphila Combined With 5-Fluorouracil Through BAX/BCL2 Dependent Apoptosis in Colorectal Cancer Cells [0.03%]
Akkermansia muciniphila联合氟尿嘧啶通过依赖BAX/BCL2的细胞凋亡协同抑制结直肠癌细胞的作用机制研究
Soumaya Menadi,Ercan Cacan
Soumaya Menadi
Colorectal cancer (CRC) continues to be one of the deadliest cancers worldwide, mainly due to late diagnosis, chemoresistance, and the complex interactions within the tumor microenvironment. Recent studies suggest that the gut bacterium Akk...
Single Intra-Articular Anakinra (IL-1Ra) Versus Betamethasone in Rabbit Post-Traumatic Knee Osteoarthritis: IL-8 Suppression and Chondrocyte Viability [0.03%]
单关节给予安卡拉（白介素-1受体拮抗剂）与倍他米松治疗兔创伤后膝骨关节炎：IL-8抑制和软骨细胞存活率的比较研究
Hüseyin Emre Tepedelenlioğlu,Duygu Dayanir,Zübeyir Elmazoğlu et al.
Hüseyin Emre Tepedelenlioğlu et al.
Post-traumatic osteoarthritis (OA) is driven by a sustained inflammatory response and progressive osteochondral damage. We compared the effects of a single intra-articular injection of anakinra (Interleukin-1 receptor antagonist; IL-1Ra) wi...
Comparative Study
Cell biochemistry and function. 2026 May;44(5):e70230. DOI:10.1002/cbf.70230 2026
Cholesterol and Its Journey Over the Centuries (1769-2025): The Highlights and Challenges [0.03%]
胆固醇及其两个半世纪的风风雨雨（1769-2025）：成就与挑战
Koshankan Chandra,Nimai Chand Chandra
Koshankan Chandra
Cholesterol is a beneficial lipid molecule considering its multifunctional roles to support physiological homeostasis and the progression of biological system at various levels, namely, membrane integrity, cushioning quality, nutrient skill...
Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia [0.03%]
慢性轻度不可预测压力通过独立于欣快症的作用下调大鼠前额皮质I exon BDNF mRNA
Mikhail Stepanichev,Danil Peregud,Anna Manolova et al.
Mikhail Stepanichev et al.
Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild unpredi...
Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture [0.03%]
单培养基中高强度短持续时间压力瞬变的神经胶质反应
J Logan Jenkins,Pratheepa Kumari Rasiah,Jacob Hardenburger et al.
J Logan Jenkins et al.
Blast-induced traumatic brain injury (bTBI) was reported in 125,000 U.S. service men and women from 2000 to 2018. With no prophylactic treatments having been granted FDA approval, there is a clear need for further understanding of the impac...
The Role of Iron in Adipose Tissue Function, Crosstalk, and Transdifferentiation [0.03%]
铁在脂肪组织功能、相互作用和转分化的角色
Jiamin Guo,Panpan Yu,Chenkang Li et al.
Jiamin Guo et al.
Brown adipose tissue (BAT) plays a crucial role in human physiology and holds significant therapeutic potential for metabolic disorders, including obesity and type 2 diabetes. White adipocytes possess the capacity to transdifferentiate into...
Elevated Circulating Follistatin Is Associated With Diabetic Status and Glycemic Dysregulation in Patients With β-Thalassemia Major [0.03%]
血清生长抑素水平与β-地中海贫血合并糖尿病的关系
Jalal Taneera,Abdul Khader Mohammed,Hind Mohammed Abed Abu Shaireh et al.
Jalal Taneera et al.
Diabetes mellitus (DM) is a frequent and debilitating complication in patients with β-thalassemia major (β-TM), driven by chronic iron overload-induced pancreatic and hepatic dysfunction. Validated biomarkers for early diabetes detection ...
Shear Stress as a Driver of Retinal Müller Glia Survival and Fibrotic Reprogramming [0.03%]
剪切应力驱动视网膜穆勒胶质细胞存活及纤维化重塑的作用机制研究
Laura Prieto-López,Christian van Oterendorp,Elena Vecino et al.
Laura Prieto-López et al.
The retina is highly influenced by mechanical cues such as intraocular fluid movement and blood flow, generating shear stress implicated in both retinal development and pathology. Müller glia, as retinal mechanosensors, are uniquely positi...