Subacute Exposure to Aldrin, Endosulfan and Lindane Differentially Alters Metabolic and Inflammatory Gene Expression in White and Brown Adipose Tissue of Male Rats [0.03%]
毒杀芬、恩丹磷和六氯氰在雄性大鼠白色和棕色脂肪组织中差异调节代谢及炎症基因表达
Nada Abdelhamid Mohamed Boujanah,Cihan Suleyman Erdogan,Engin Sumer et al.
Nada Abdelhamid Mohamed Boujanah et al.
Persistent organic pollutants such as organochlorine pesticides (OCPs) have been implicated in obesity and metabolic dysfunction. As they bioaccumulate in adipose tissue, OCPs may act as obesogens, but in vivo evidence for aldrin, endosulfa...
Role of Fatty Acid Oxidation in Crohn's Disease and Ulcerative Colitis: Metabolomics Analysis and Experimental Evidence [0.03%]
脂肪酸氧化在克罗恩病和溃疡性结肠炎中的作用：代谢组学分析和实验证据
Fang Yan,Shimin Wu,Wenqiang Yuan et al.
Fang Yan et al.
The metabolic determinants that distinguish Crohn's disease (CD) from ulcerative colitis (UC) and their roles in driving immune dysregulation remain elusive. We aimed to identify systemic metabolic signatures of inflammatory bowel disease (...
Phytohemagglutinin: A Tool for Inducing Neuroinflammation Mediated In Vitro and In Vivo Modeling of Alzheimer's Disease Pathology [0.03%]
植物血凝素：一种用于诱导体内外介导的神经炎症模型阿尔茨海默病病理学的工具
Sarosh Farooq Khan,Maha Shahid,Shabana Usman Simjee
Sarosh Farooq Khan
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and the major cause of dementia globally. One of the major barriers to curing AD is the lack of experimental models that fully recapitulate the complexity of human AD pa...
Thermodynamic Frontiers in Hemoglobin-Inspired Polymer Science for Diagnosis and Modulation of Neurodegenerative Diseases [0.03%]
受血红蛋白启发的聚合物科学在神经退行性疾病诊断和调控方面的热力学前沿
Mohammad Edrisi,Navid Rabiee
Mohammad Edrisi
The thermodynamic logic underlying hemoglobin's cooperative binding and reversible conformational transitions offers a powerful conceptual model for reimagining polymer design in neurodegenerative medicine. In this review perspective, we ou...
ADAM20 Participates Modestly to Fertilization as Its Absence Leads to In Vitro Hypofertility in Mouse [0.03%]
ADAM20在受精中的作用微弱，其缺失会导致小鼠体外授精能力下降
Marie-Sophie Girault,Sophie Dupuis,Rémi Pierre et al.
Marie-Sophie Girault et al.
A mutation of the ADAM20 gene was described in an infertile patient whose spermatozoa were observed accumulating in the perivitelline space of oocytes. To decipher its role in the fertilization process, we produced a mouse model knock-out (...
Apoptotic Bodies: Decoding Their Functional Messages in Physiology and Pathology [0.03%]
凋亡小体：生理和病理功能信息的解码
Shanshan Xi,Weiran Meng,Xiaochi Zhu et al.
Shanshan Xi et al.
Apoptosis, as the predominant form of programmed cell death, plays a crucial role in maintaining tissue homeostasis. Apoptotic bodies (ABs), which are extracellular vesicles released during the terminal phase of apoptosis, were initially ch...
Hong Zhang,Qihao Guo,Benson Peter Mugaka et al.
Hong Zhang et al.
The ARHGEF (Rho guanine nucleotide exchange factor) family acts as a key upstream regulator of Rho GTPases, including RhoA, Rac1, and Cdc42. It plays critical roles in cytoskeletal remodeling, cell migration, vascular tone regulation, and i...
Tengteng Huang,Shihao Zhou,Xiaoling Chen et al.
Tengteng Huang et al.
Myokines are defined as a class of bioactive molecules-including metabolites, peptides, and proteins-released from skeletal muscle cells and promoted by exercise. Recently, myokine-mediated muscle-organ crosstalk has sparked increased inter...
GRWD1 as a Novel Signature and It Down Regulates IFN in Skin Aging [0.03%]
GRWD1作为一种新的皮肤衰老标志物及其对IFN的下调作用
Fei Tan,Yaoqun Wang,Peng Xu et al.
Fei Tan et al.
Deep mining of the molecular mechanisms underlying skin aging is critical for the development of novel therapeutic targets. The aim of this study was to explore potential key signatures and underlying mechanisms in skin aging. Bioinformatic...
Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers [0.03%]
肥胖与乳腺癌进展之间的机制联系：细胞串扰、代谢重组和微环境驱动因素
Charlise Basson,Michael S Pepper,Anna M Joubert et al.
Charlise Basson et al.
Obesity is increasingly recognised as an important factor contributing to cancer progression, particularly in breast cancer. However, the cellular and molecular mechanisms underlying obesity-driven breast cancer remain unclear. Several theo...