Affinity of Abelmoschus Esculentus Lectin for the Midpiece of Ovine Spermatozoa and Its Effects on Functional Parameters [0.03%]
Abelmoschusesculentus凝集素与卵精精子中段的亲和力及其对功能性参数的影响
Alessandra Cardoso da Silva,Antonio Sergio Varela Junior,Raqueli Teresinha França et al.
Alessandra Cardoso da Silva et al.
Lectins are carbohydrate-binding proteins that recognize specific glycan patterns on cell surfaces and have been increasingly explored as analytical tools in reproductive biology. This study characterized the interaction of a lectin isolate...
Asha Jangir,Abhishek Swami,Neha Kumari et al.
Asha Jangir et al.
Monkeypox virus (MPXV), a zoonotic viral disease first identified in 1958, has re-emerged as a major global health concern. The first human case was reported in 1970 in the Democratic Republic of Congo (DRC), and since then, MPXV has demons...
Anticancer Therapeutic Potential of Mitochondria-Targeted Antioxidants Against N-Nitrosodiethylamine-Induced Hepatocarcinogenesis [0.03%]
线粒体靶向型抗氧化剂抗肝癌的抗癌治疗潜能：亚硝基二乙胺致肝细胞癌变模型研究
Qsee H S,Prasad Kisan Tambe,Sachin Shetty et al.
Qsee H S et al.
Mitochondria-targeted antioxidants (MTAs) accumulate in mitochondria to mitigate mitochondrial oxidative stress. The present study investigates the anticancer therapeutic potential of two MTAs, MitoQ, and Mito-TEMPO, in rodent N-nitrosodiet...
ATP Hydrolysis Gates an Ultra-Rapid Unwinding Mode of AfXPB Revealed by DNA Electrochemistry [0.03%]
基于DNA电化学的ATP水解触发AfXPB超快速解旋模式的研究
Melodee O Seifi,Victoria K Wolf,Akbar Ali et al.
Melodee O Seifi et al.
DNA helicases play a central role in DNA metabolism, enabling recombination, replication, transcription, translation, and repair. Recently, an unexpectedly rapid, exponential ATP-stimulated DNA unwinding rate was observed with an Archaeoglo...
Targeted Micronutrient Supplementation in Diabetic Retinopathy With MTHFR Polymorphisms: Biomarker Shifts and Clinical Uncertainty [0.03%]
糖尿病视网膜病变患者中MTHFR基因多态性的靶向微量营养素补充：生物标志物变化与临床不确定性
Mohamed Msa
Mohamed Msa
Disturbances in one-carbon metabolism, endothelial signaling, oxidative stress, and coagulation balance are central features of diabetes-associated microvascular disease, and targeted micronutrient supplementation-including L-methylfolate, ...
Biomimetic Shell-Core Nanoparticles Loaded With Apatinib for Dual Starvation and Chemodynamic Combination Therapy of Lung Cancer [0.03%]
仿生壳核型负载阿帕替尼纳米粒子的乏氧/化学动力学协同治疗肺癌研究
Chao Luo,Guixue Yang,Peng Zhang et al.
Chao Luo et al.
Tumor cells rely heavily on vascular nutrient supply and glucose metabolism to sustain proliferation, while maintaining redox homeostasis through reprogrammed antioxidant systems, making it difficult for single starvation therapy or chemody...
Nerve Growth Factor: A Multifaceted Regulator of Pain, Inflammation, and Tissue Remodeling in Bone and Joint Disorders [0.03%]
神经生长因子：骨关节疾病中疼痛、炎症和组织重塑的多面调节器
Zuping Wu,Ruifeng Song,Fu Zheng et al.
Zuping Wu et al.
As an essential member of the neurotrophic factor family, nerve growth factor (NGF) plays multifaceted regulatory roles in the pathological processes of bone and joint diseases through its dual signaling mechanisms involving high-affinity r...
Differential Cytotoxicity of Hydroxycinnamic Acids in Cancer Cells: Structure-Activity Insights From a Broad Panel of Cell Lines [0.03%]
羟基肉桂酸类化合物对癌细胞的差异性细胞毒性：来自一系列广谱细胞系的结构活性洞察
Kadriye Aslıhan Onat Taşdelen,Merve Sezer Kürkçü,Hatice Öztürkel Kabakaş et al.
Kadriye Aslıhan Onat Taşdelen et al.
Phenolic acids, abundant in plant-based foods, are increasingly investigated for their anticancer potential. This study systematically evaluated the cytotoxic effects of three hydroxycinnamic acids-trans-cinnamic acid (tCA), p-coumaric acid...
Double-Stranded DNA Sensing cGAS-STING Immune Signaling in a Rat Co-Culture Model of the Blood-Brain Barrier [0.03%]
基于血脑屏障的共培养体系中双链DNA感应cGAS-STING免疫信号通路的研究
András Harazin,Line S Reinert,Parvez Alam et al.
András Harazin et al.
Double-stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS-STING signaling pathway comprising the cyclic GMP-AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors. Th...
Preliminary Evidence of GLUT4 Upregulation and Biocompatibility of Syzygium caryophyllatum-Derived Silver Nanoparticles in 3T3-L1 Preadipocytes [0.03%]
Syzygium caryophyllatum衍生的银纳米颗粒上调GLUT4和生物相容性在3T3-L1前脂肪细胞中的初步证据
Santosh Mallikarjun Bhavi,Ramesh Babu Yarajarla
Santosh Mallikarjun Bhavi
AMPK signaling and GLUT4 trafficking are key regulators of cellular glucose handling; however, the effects of biogenic silver nanoparticles (AgNPs) in preadipocyte models remain underexplored. This study characterizes Syzygium caryophyllatu...