Cardiac Glycogen Fluctuations Are Robust in Short-Term Than Long-Term Binge Drinking and Follows a Sex Specific Manner [0.03%]
短期醉酒比长期醉酒引起的心脏糖原波动更明显且具有性别差异性
Victoria Nelson,Katlyn Heneghan,Daniel Rafferty et al.
Victoria Nelson et al.
Drinking behavior, especially binge drinking, has a debilitating impact on systemic health. In this study, we report that in the absence of any changes in hepatic lactate dehydrogenase activity, the cardiac glycogen level fluctuates followi...
Antioxidant Defenses in the Kidneys and Heart of the Freshwater Fish Astyanax lacustris Subjected to High (31°C) and Low (15°C) Temperatures [0.03%]
Astyanax lacustris 鱼类在高温（31℃）和低温（15℃）下的肾脏和心脏抗氧化防御反应
Ana Paula Nascimento Corrêa,Luiz Neves Neto,Maria Rosa Dmengeon Pedreiro de Souza et al.
Ana Paula Nascimento Corrêa et al.
Aquatic ecosystems have their abiotic and biotic factors constantly altered by various factors. Among them, water temperature is an abiotic factor that can significantly affect fish physiology, increasing energy demand, which can impact hom...
Dulcitol Selectively Inhibits Proliferation and Metastasis Related Markers in Triple-Negative Breast Cancer: Uncovering an Unforeseen Activity [0.03%]
二癸酸甘露二醇酯可选择性抑制三阴乳腺癌的增殖和转移相关标志物：一项意外发现活动披露研究
Betul Yanik,Filiz Bakar-Ates
Betul Yanik
Breast cancer remains the most commonly diagnosed cancer and a leading cause of cancer-related mortality among women worldwide. Despite advancements in treatment, resistance and toxicity issues highlight the urgent need for novel, effective...
Protease-Activated Receptor 2 Activation Provokes an Increase in Intracellular Calcium and Serotonin Secretion in a Human Enteroendocrine Cell Line [0.03%]
激活蛋白酶活化受体2可诱导人肠内分泌细胞系胞内钙增加和5-羟色胺释放
Beatrix Pfanzagl,Erika Jensen-Jarolim
Beatrix Pfanzagl
The P-STS human ileal enteroendocrine tumor cell line responds with an increase in intracellular calcium and serotonin secretion to acetylcholine and histamine. Here we show that the cells react similarly to the protease-activated receptor ...
The Role of Ferroptosis on the Pathogenesis and Therapy of Hepatocellular Carcinoma [0.03%]
铁死亡在肝细胞癌发生发展及治疗中的作用研究进展
Xue Wang,Jinhong Wang,Wentong Li et al.
Xue Wang et al.
Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate due to frequent recurrence and lack of efficient therapies. Recent investigations have revealed that ferroptosis plays a crucial role in the progression of tumor...
RETRACTION: Autophagy Induction by Xanthoangelol Exhibits Anti-Metastatic Activities in Hepatocellular Carcinoma [0.03%]
撤稿：异 Angelol 通过诱导自噬表现出对肝细胞癌的抗转移活性
X. Yang, J. Xie, X. Liu, Z. Li, K. Fang, L. Zhang, M. Han, Z. Zhang, Z. Gong, X. Lin, X. Shi, H. Gao and K. Lu, "Autophagy Induction by Xanthoangelol Exhibits Anti-Metastatic Activities in Hepatocellular Carcinoma," Cell Biochemistry & Func...
Bridging Pathogens: Epstein-Barr Virus and Helicobacter pylori in Gastric Cancer Stem Cell Regulation [0.03%]
病原体在胃癌干细胞调控中的桥梁作用：Epstein-Barr病毒和Helicobacter pylori的作用
Harshita Shrivastava,Meenakshi Kandpal,Dharmendra Kashyap et al.
Harshita Shrivastava et al.
Gastric cancer remains the primary cause of cancer-related deaths worldwide, where gastric cancer stem cells play an essential role in tumor growth and resistance to various gastric cancer therapies. Emerging evidence suggests that the inte...
Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression [0.03%]
2型糖尿病进展过程中组织间衰老标志物p16 / p21的时空异质性分析
Jiayu Yan,Zimei Yi,Siyi Chen et al.
Jiayu Yan et al.
This study investigates p16/p21 senescence marker heterogeneity in diabetes-related tissues using the p21-3MR mouse model, focusing on p16 and p21 as senescence markers. Type 2 diabetes, a common age-related disease, impacts multiple organs...
Determination of the In Vitro Cytotoxic Activities of Several Coumarin Derivatives on Neuroblastoma Cell Lines With In Silico Inhibitory Effects on CDK9, VEGFR2 and EGFR Proteins and ADME Studies [0.03%]
几种香豆素衍生物的体外细胞毒活性及对CDK9、VEGFR2和EGFR蛋白的抑制作用的分子对接研究以及ADME性质的研究
Fatih Caglar Celikezen,Kamuran Sarac,Ercan Seyhan et al.
Fatih Caglar Celikezen et al.
Due to their stable nature and medical applicability properties, coumarin derivatives have fascinated medicinal chemists in the discovery of novel therapeutics. In this study, the cytotoxic/anticancer properties of some newly synthesized co...
Evaluation of the Hypothalamus-Hypophysis-Adrenal Axis in Male Rats Programmed by Gestational Protein Restriction [0.03%]
妊娠期蛋白限制对雄性大鼠下丘脑-垂体-肾上腺轴的程序化效应研究
Vinicius Schiavinatto Mariano,José Antonio Rocha Gontijo,Patrícia Aline Boer
Vinicius Schiavinatto Mariano
Diet manipulations during the gestation of animal models, in this case, the lipoprotein diet, mimic the alterations related to low birth weight, providing studies of the mechanisms involved in chronic disease development in later life. Our ...