GdX/UBL4A null mice exhibit mild kyphosis and scoliosis accompanied by dysregulation of osteoblastogenesis and chondrogenesis [0.03%]
GdX / UBL4A基因敲除小鼠出现轻度脊柱侧弯和驼背并伴有成骨细胞分化和软骨发育的失调现象
Jiao Liang,Jun Li,Yanxia Fu et al.
Jiao Liang et al.
GdX, also named ubiquitin-like protein 4A, is a ubiquitin-domain protein characterized by a ubiquitin-like domain that regulates the movement of misfolded proteins from the endoplasmic reticulum membrane to proteasome. However, its function...
ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia [0.03%]
ERK1 / 2 和 Akt 磷酸化修饰对严重缺氧下MGF-E 氨基肽调节BMSCs 细胞形态和迁移能力但不影响促血管生成能力的作用是必要的
Yongqiang Sha,Li Yang,Yonggang Lv
Yongqiang Sha
Severe hypoxia inhibits the adhesion and mobility of bone marrow-derived mesenchymal stem cells (BMSCs) and limits their application in bone tissue engineering. In this study, CoCl2 was used to simulate severe hypoxia and the effects of mec...
Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2 O2 -induced oxidative stress [0.03%]
SH-SY5Y细胞类神经分化适应于温和且短暂的H2O2诱导的氧化应激反应
Rachid Akki,Rosalba Siracusa,Rossana Morabito et al.
Rachid Akki et al.
Preconditioning (PC) is a cell adaptive response to oxidative stress and, with regard to neurons, can be considered as a neuroprotective strategy. The aim of the present study was to verify how neuronal-like differentiated SH-SY5Y cells ada...
DJ-1 plays an obligatory role in the cardioprotection of delayed hypoxic preconditioning against hypoxia/reoxygenation-induced oxidative stress through maintaining mitochondrial complex I activity [0.03%]
DJ-1在延迟缺氧适应通过维持线粒体复合物I活性对抗缺氧/复氧诱导的氧化应激中起重要作用
Hao Ding,Xing-Wang Xu,Huan Wang et al.
Hao Ding et al.
DJ-1 was recently reported to mediate the cardioprotection of delayed hypoxic preconditioning (DHP) by suppressing hypoxia/reoxygenation (H/R)-induced oxidative stress, but its mechanism against H/R-induced oxidative stress during DHP is no...
Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells [0.03%]
自噬作用在MDAMB231细胞急性氨基酸饥饿期间维持氨基酸和ATP水平方面必不可少
Mark Thomas,Tanja Davis,Ben Loos et al.
Mark Thomas et al.
Autophagy plays a major role in the adaptive metabolic response of cancer cells during adverse conditions such as nutrient deprivation. However, specific data that assess metabolite profiles in context with adenosine triphosphate (ATP) avai...
Fish bone peptide promotes osteogenic differentiation of MC3T3-E1 pre-osteoblasts through upregulation of MAPKs and Smad pathways activated BMP-2 receptor [0.03%]
鱼骨肽通过上调MC3T3-E1前成骨细胞BMP-2受体活化的MAPKs和Smad通路促进其成骨分化
Seong-Yeong Heo,Seok-Chun Ko,Seung Yun Nam et al.
Seong-Yeong Heo et al.
Fish bone, a by-product of fishery processing, is composed of protein, calcium, and other minerals. The objective of this study was to investigate the effects of a bioactive peptide isolated from the bone of the marine fish, Johnius belenge...
Inhibition of the CSF-1 receptor sensitizes ovarian cancer cells to cisplatin [0.03%]
CSF-1受体抑制能使卵巢癌细胞对顺铂的治疗更加敏感
Rong Yu,Hao Jin,Congcong Jin et al.
Rong Yu et al.
Ovarian cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely used in locally advanced ovarian cancer patients. Acquired or de novo cisplatin resistance remains the barrier to patient survival, ...
Mesenchymal stem cells promote cell invasion and migration and autophagy-induced epithelial-mesenchymal transition in A549 lung adenocarcinoma cells [0.03%]
间充质干细胞通过自噬诱导上皮间充质转化促进A549肺腺癌细胞侵袭和迁移
Dan Luo,Shiyuan Hu,Chunlan Tang et al.
Dan Luo et al.
Mesenchymal stem cells (MSCs) are recruited into the tumour microenvironment and promote tumour growth and metastasis. Tumour microenvironment-induced autophagy is considered to suppress primary tumour formation by impairing migration and i...
Quantitative proteomics reveals that miR-222 inhibits erythroid differentiation by targeting BLVRA and CRKL [0.03%]
定量蛋白质组学揭示miR-222通过靶向BLVRA和CRKL抑制红细胞分化
Li Jiang,Xing Wang,Yong Wang et al.
Li Jiang et al.
miR-222 plays an important role in erythroid differentiation, but the potential targets of miR-222 in the regulation of erythroid differentiation remain to be determined. The target genes of miR-222 were identified by proteomics combined wi...
ILEI is an important intermediate participating in the formation of TGF-β1-induced renal tubular EMT [0.03%]
ILEI是TGF-β1诱导的肾小管上皮间质转化中的重要中介分子
Xing Zhao,Gang Luo,Yan Fan et al.
Xing Zhao et al.
Renal interstitial fibrosis is the most common process by which chronic kidney diseases progress to end-stage renal failure. Epithelial-to-mesenchymal transitions (EMTs) play a crucial role in the progression of renal interstitial fibrosis....