Japanese Encephalitis Virus and Host Innate Immunity: Insights Into TLR Signaling, PRR Crosstalk, and Viral Immune Evasion [0.03%]
日本乙型脑炎病毒与宿主先天免疫：TLR信号、PRR串扰和病毒免疫逃避的新见解
Mohammad Enamul Hoque Kayesh,Michinori Kohara,Kyoko Tsukiyama-Kohara
Mohammad Enamul Hoque Kayesh
Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by p...
Redox Metabolism and Metabolic Vulnerabilities in Diabetes-Driven Pancreatic Cancer: Targeting System Xc-, mTORC1, and Disulfidptosis as Therapeutic Strategy [0.03%]
糖尿病驱动的胰腺癌中的氧化还原代谢和代谢弱点：将系统Xc-，mTORC1和二硫化依赖性蛋白水解作为治疗策略
Francis Jegan Raj,Anish Ruban Solomonraj,Parimelazhagan Thangaraj
Francis Jegan Raj
Type 2 diabetes mellitus (T2DM) is increasingly recognized as a significant risk factor for pancreatic cancer, with both diseases sharing complex metabolic and molecular underpinnings. Insulin resistance, chronic inflammation, and aberrant ...
Identification of PRKCB, NLRC4, and TNFSF10 as Key Regulators of the Lipid Metabolism-Autophagy Network in Atherosclerosis [0.03%]
动脉粥样硬化中鉴定出PRKCB、NLRC4和TNFSF10是脂代谢-自噬网络的关键调节因子
Min Li,Yanjun Sun,Yanyi Sun et al.
Min Li et al.
Background: The occurrence and development of atherosclerosis (AS) are closely related to disorders of lipid metabolism and dysfunction of autophagy. However, the key regulatory genes and immune microenvironment character...
Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits [0.03%]
跳跃基因的定量控制：从基因组可塑性到免疫调控电路
Irving Jesús Reyes-Barragán
Irving Jesús Reyes-Barragán
Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context-dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evide...
Xingshun Wang
Xingshun Wang
RNA helicases are a large family of enzymes crucial for virtually all aspects of RNA metabolism, forming the backbone of gene expression regulation. Among them, DEAH-box helicase 33 (DHX33) has emerged as a pivotal player in fundamental cel...
Oral Calcium Supplements With L-Proline and Sodium Zinc Chlorophyllin Preserve Elevated Transepithelial Calcium Transport in Spontaneously Hypertensive Rats [0.03%]
口服钙补充剂与L-脯氨酸和钠锌叶绿素可使自发性高血压大鼠的跨上皮钙转运量保持在较高水平
Pornpailin Upanan,Kannikar Wongdee,Surathouch Thongprong et al.
Pornpailin Upanan et al.
Hypertensive rodents often exhibit bone loss and osteopenia with impaired bone formation. We hypothesized that spontaneously hypertensive rats (SHR) could compensate for osteopathy through certain mechanisms, particularly intestinal calcium...
Exosomal MicroRNA-424-5p From Polycystic Ovary Syndrome Follicular Fluid Attenuates Ovarian Inflammation via Targeting the Fibroblast Growth Factor 2/Fibroblast Growth Factor Receptor 1 Axis [0.03%]
多囊卵巢综合征卵泡液来源的外泌体微小RNA-424-5p通过靶向成纤维细胞生长因子2/成纤维细胞生长因子受体1轴减轻卵巢炎症
Dong Yuan,Xiaoming Hao,Jing Luo et al.
Dong Yuan et al.
Sustained low-grade inflammation is increasingly recognized as a central element in how polycystic ovary syndrome (PCOS) develops. Here we set out to clarify what role follicular fluid (FF)-borne exosomal miR-424-5p plays in shaping ovarian...
Toxicity of Organic Acids Leading to Renal Dysfunction in Glutaric Acidemia Type I: A Mini Review [0.03%]
异谷氨酸血症Ⅰ型肾功能损伤的有机酸毒性研究：综述
Luísa Tedesco,Gillian Guerreiro,Bianca Gomes Dos Reis et al.
Luísa Tedesco et al.
Glutaric Acidemia type I is an inborn error of metabolism that impairs the metabolism of lysine, hydroxylysine, and tryptophan, leading to neurologic and, as more recently described, acute and chronic kidney damage. This mini review explore...
Integration of Three-Dimensional Cell Culture Techniques and Photobiomodulation for Supportive Differentiation of Adipose-Derived Stem Cells into Smooth Muscle [0.03%]
三维细胞培养技术与光生物调节结合促进脂肪源干细胞向平滑肌细胞分化研究进展
Christevie Mbuyu,Heidi Abrahamse,Anine Crous
Christevie Mbuyu
Photobiomodulation (PBM) has gained recognition as a promising, non-invasive strategy to enhance the differentiation of adipose-derived stem cells (ADSCs) into smooth muscle cells (SMCs), particularly when used together with a three-dimensi...
Nektarios Barabutis
Nektarios Barabutis
Endothelial barrier dysfunction is the hallmark of severe disease, including sepsis and lung injury. The present study summarizes recent advances in the development of pharmacotherapies to counteract endothelium-dependent disorders, highlig...