Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway [0.03%]
香草醇通过Bcl2/Bid途径诱导三阴性乳腺癌的线粒体介导的细胞凋亡作用评估研究
Sudhina Sufina Nazar,Aswathy Vadakkumkattle Ajaykumar,Janeesh Plakkal Ayyappan
Sudhina Sufina Nazar
Among 15-20 cases of breast cancer, triple-negative breast cancer (TNBC) is the deadliest form of the disease. The most effective form of treatment for this type of cancer is still targeted chemotherapy because it lacks hormone receptors. M...
Comprehensive Pan-Cancer Analysis of ABCA1: Insights From Multi-Omics Data and Exploratory Validation in Esophageal Squamous Cell Carcinoma [0.03%]
泛癌分析ABCA1：来自多组学数据的见解及食管鳞状细胞癌中的探索性验证
Chenyang Wang,Hanbing Wang,Xi Chen et al.
Chenyang Wang et al.
Cancer remains a major cause of global mortality, necessitating the identification of novel biomarkers to improve prognosis and guide therapy. ABCA1, an ATP-binding cassette transporter involved in cholesterol efflux, has been implicated in...
Mycoplasma Contamination Alters the Expression Profile of Pro-Inflammatory Cytokines by Human Innate Immune Cells [0.03%]
支原体污染改变人固有免疫细胞中促炎症细胞因子的表达谱
Patricia Gogesch,Stefanie Kronhart,Marc A Niles et al.
Patricia Gogesch et al.
The impact of Mycoplasma contaminations on in vitro test systems has been extensively discussed and in vitro studies have demonstrated various effects on the physiology of the contaminated cell line. Thus far, little is known about the effe...
Modulation of Prostate Cancer Cell Behavior Through Acetylsalicylic Acid-Treated Prostate Epithelial Cell-Derived Conditioned Medium [0.03%]
通过阿司匹林处理的前列腺上皮细胞条件培养基调节前列腺癌细胞行为
Dilşad Özerkan,Selda Durukan,Mahsa Koucheki et al.
Dilşad Özerkan et al.
Acetylsalicylic acid (ASA, aspirin), derived from salicylic acid in willow bark, is known for its analgesic, anti-inflammatory, and antiplatelet properties. Beyond cardiovascular protection, increasing evidence suggests that ASA may reduce ...
Synergistic Effect of Digoxin and Cisplatin on Redox Imbalance in HeLa Cells [0.03%]
地高辛和顺铂联合使用对HeLa细胞氧化还原稳态的协同影响作用研究
Duane Gischewski Pereira,Israel José Pereira Garcia,Graziele Aparecida Silva Maia et al.
Duane Gischewski Pereira et al.
Our previous study demonstrated a potent synergistic antitumor effect between 1 nM digoxin and 1 μM cisplatin in cervical cancer cells, which was dependent on the modulation of the signaling pathway involving Na, K-ATPase/Src. Because of t...
Cell-Type-Specific Regulation of Ferroptosis in Atherosclerosis: Mechanisms and Therapeutic Potential of Natural Products [0.03%]
动脉粥样硬化中铁死亡的细胞类型特异性调控：天然产物的作用机制及治疗潜力
Ziwei Wang,Xuchun Zhong,Weiwei Peng et al.
Ziwei Wang et al.
Ferroptosis is a regulated form of cell death in which disturbed iron metabolism, accumulation of peroxidized membrane lipids, and insufficient glutathione peroxidase 4 (GPX4) activity converge to injure vascular cells. In atherosclerosis, ...
Structural-Molecular Linkage Shapes the Adaptive Traits of Nuptial Pads in Male Rana chensinensis [0.03%]
中国特有物种黑斑蛙雄性婚垫的结构-分子联结及其适应性特征研究
Guoxiang Zhang,Xinyi Li,Shuangyan Luo et al.
Guoxiang Zhang et al.
Nuptial pads represent a key sexually dimorphic trait in anurans, with male Rana chensinensis exhibiting these structures on the Finger I of forelimbs. However, the specialized mechanisms underlying their functional adaptation remain poorly...
Combined Time-Restricted Feeding and Physical Exercise Attenuate ER Stress and Improve Liver Inflammation and Collagen Deposition in Aged Mice [0.03%]
结合限时进食和运动减轻衰老小鼠的内质网应激及肝炎和胶原沉积
Guilherme Correia Ferri Antonio,Beatriz de Souza Pitoli,Ana Paula Azevêdo Macêdo et al.
Guilherme Correia Ferri Antonio et al.
Aging is associated with progressive impairment of hepatic adaptive capacity, including mitochondrial dysfunction, oxidative stress, and disruption of proteostasis. Persistent activation of the unfolded protein response (UPR), particularly ...
AAV Vector-Mediated Modulation of Signaling Pathways in Neurological Disorders: Insights From Cellular, Animal, and Human Studies [0.03%]
基于细胞、动物和人类研究的神经疾病中AAV载体介导的信号通路调节作用
Majid Reza Farrokhi,Kamran Hosseini
Majid Reza Farrokhi
One of the most efficient and promising viral vectors for the treatment of central nervous system (CNS) and peripheral nervous system (PNS)-related diseases is adeno-associated virals (AAVs), which in recent years, researchers have succeede...
Epithelial-Mesenchymal Plasticity in Cancer: Transcriptional Regulation, Biomarker Challenges, and Emerging Therapeutic Opportunities [0.03%]
癌症上皮间质可塑性的转录调控、生物标志物挑战及潜在治疗策略
Dhrruv Shah,Rajasekhar Reddy Alavala
Dhrruv Shah
Epithelial-mesenchymal transition (EMT) is increasingly recognized as a dynamic process of epithelial-mesenchymal plasticity (EMP) rather than a binary switch between epithelial and mesenchymal phenotypes. This plasticity enables tumor cell...