Elissaios Karageorgiou,Bruce L Miller
Elissaios Karageorgiou
In this review, the authors outline a clinical approach to frontotemporal lobar degeneration (FTLD), a term coined to describe a pathology associated with atrophy of the frontal and temporal lobes commonly seen with abnormal protein aggrega...
Dementia with Lewy bodies [0.03%]
路易体痴呆
Mary Catherine Mayo,Yvette Bordelon
Mary Catherine Mayo
Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the...
Multiple system atrophy [0.03%]
多系统萎缩症
Tasneem Peeraully
Tasneem Peeraully
Multiple system atrophy (MSA) is a rare adult-onset synucleinopathy associated with dysautonomia and the variable presence of poorly levodopa-responsive parkinsonism and/or cerebellar ataxia. Other clinical symptoms that can be associated w...
Corticobasal degeneration [0.03%]
皮质基底节变性
Ana M Grijalvo-Perez,Irene Litvan
Ana M Grijalvo-Perez
Among the atypical parkinsonian syndromes, corticobasal degeneration (CBD) is probably the most challenging disorder to diagnose antemortem. It can present with multiple phenotypes, none of them specific enough to lead to an unequivocal dia...
Lawrence I Golbe
Lawrence I Golbe
Progressive supranuclear palsy is a disorder of tau protein aggregation. Its clinical spectrum is now known to be wider than originally described, with a phenotype resembling Parkinson disease accounting for a third of cases. However, at le...
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia [0.03%]
进行性核上性麻痹：包括脑干、基底节和小脑并具有垂直凝视和假性延髓瘫痪、颈肌张力障碍和痴呆的异质变性
John C Steele,J Clifford Richardson,Jerzy Olszewski
John C Steele
Case Reports
Seminars in neurology. 2014 Apr;34(2):129-50. DOI:10.1055/s-0034-1377058 2014
John C Steele
John C Steele
Parkinsonism recalls James Parkinson of London and his description of six patients with "paralysis agitans" in 1817, which neurologist Jean-Marie Charcot renamed Parkinson disease. Its variants, referred to as atypical parkinsonian disorder...
Yvette Bordelon,Carlos Portera-Cailliau
Yvette Bordelon
Gabriel Chamie,Carina Marquez,Anne Luetkemeyer
Gabriel Chamie
Central nervous system tuberculosis (CNS TB) represents one of the most devastating manifestations of TB. HIV dramatically increases the risk of TB disease, including CNS TB. Early recognition and treatment of CNS TB, and TB meningitis in p...
Mary C Masters,Beau M Ances
Mary C Masters
Human immunodeficiency virus (HIV) enters the brain soon after seroconversion and can cause HIV-associated neurocognitive disorders (HAND). Although the more severe and progressive forms of HAND are less prevalent due to combination antiret...