Mutation patterns and prognostic analysis of BRAF/KRAS/PIK3CA in colorectal cancer [0.03%]
结直肠癌BRAF/KRAS/PIK3CA突变特征及预后分析
Chengfeng Wang,Diling Pan
Chengfeng Wang
Background and objective: Aberrant gene expression and abnormal signaling pathways often occur in patients with colorectal cancer, in which mutations in B-Raf Proto-Oncogene (BRAF), KRAS Proto-Oncogene (KRAS), and Phospha...
Association between alanine aminotransferase and all-cause mortality rate: Findings from a study on Japanese community-dwelling individuals [0.03%]
丙氨酸氨基转移酶与全因死亡率的关系：基于日本社区居民的研究结果
Ryuichi Kawamoto,Asuka Kikuchi,Taichi Akase et al.
Ryuichi Kawamoto et al.
Background: This study examined the relationship between survival prognosis and alanine aminotransferase (ALT), a critical factor contributing to aging-related health and mortality. The research is based on a follow-up st...
Identification of potential pathogenic genes for severe aplastic anemia by whole-exome sequencing [0.03%]
全外显子组测序识别重度再生障碍性贫血致病基因
Yang Zhang,Yu Zhang,Hongyu Ge et al.
Yang Zhang et al.
Background: Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure due to hyperfunction of CD8+ T cells. While, the genetic background of SAA is still unknown. In this study, we tried to explore the poss...
Anakinra treatment efficacy in reduction of inflammatory biomarkers in COVID-19 patients: A meta-analysis [0.03%]
安卡拉治疗对COVID-19患者炎症生物标志物降低有效性的meta分析
Zunaira Naveed,Musharraf Sarwar,Zahid Ali et al.
Zunaira Naveed et al.
Introduction: Anakinra is being empirically considered for the treatment of COVID-19 patients. The aim is to assess the efficacy of anakinra treatment on inflammatory marker reduction, including c-reactive protein (CRP) c...
A novel de novo missense mutation in EFTUD2 identified by whole-exome sequencing in mandibulofacial dysostosis with microcephaly [0.03%]
全外显子组测序发现EFTUD2新发错义突变与小头畸形伴面骨发育不全症相关
Mei Yang,Yanyan Liu,Ziyuan Lin et al.
Mei Yang et al.
Background: Mandibulofacial dysostosis with microcephaly (MFDM) is a rare multiple malformation syndrome characterized by malar and mandibular hypoplasia and congenital- or postnatal-onset microcephaly induced by haploins...
Clinical symptoms, diagnosis, treatment, and outcome of COVID-19-associated encephalitis: A systematic review of case reports and case series [0.03%]
COVID-19相关性脑炎的临床表现、诊断、治疗及转归：病例报告和病例系列的系统综述
Maryam Koupaei,Negar Shadab Mehr,Mohamad Hosein Mohamadi et al.
Maryam Koupaei et al.
Introduction: Since COVID-19 outbreak, various studies mentioned the occurrence of neurological disorders. Of these, encephalitis is known as a critical neurological complication in COVID-19 patients. Numerous case report...
Rapid progression of myelofibrosis in polycythemia vera patient carrying SRSF2 c.284C>A p.(Pro95His) and unique ASXL1 splice site c.1720-2A>G variant [0.03%]
携带SRSF2剪切突变(c.284C>A，p.Pro95His)及独特ASXL1拼接位点突变(c.1720-2A>G)的真性红细胞增多症患者快速进展为骨髓纤维化
Zuzanna Kanduła,Renata Kroll-Balcerzak,Krzysztof Lewandowski
Zuzanna Kanduła
Background: The prognosis in polycythemia vera (PV) is comparatively favorable, but individual myelofibrosis/leukemic progression risk is heterogeneous. About a quarter of patients progress to the fibrotic phase after 20 ...
Neutrophil extracellular traps are associated with enhanced procoagulant activity in liver cirrhosis patients with portal vein thrombosis [0.03%]
中性粒细胞胞外陷阱与门静脉血栓形成肝硬化患者的促凝活性增强有关
Yueyi Xing,Yueping Jiang,Shichao Xing et al.
Yueyi Xing et al.
Objective: Patients with liver cirrhosis (LC) commonly exhibit hypercoagulability and tend to develop thrombosis. Neutrophil extracellular traps (NETs) are associated with a variety of thrombotic conditions, but their pos...
MALAT1 regulates PCT expression in sepsis patients through the miR-125b/STAT3 axis [0.03%]
LncRNA MALAT1通过miR-125b/STAT3轴调控脓毒症患者的PCT表达
Yuanjie Le,Yongwei Shi
Yuanjie Le
Background: Procalcitonin (PCT) is an important marker in diagnosing sepsis. However, some other diseases can also cause an increase in PCT. PCT still has some limitations in the clinical application of diagnosing sepsis....
Arezoo Asadi,Negar Shadab Mehr,Mohamad Hosein Mohamadi et al.
Arezoo Asadi et al.
Introduction: Obesity is a major health problem that is associated with many physiological and mental disorders, such as diabetes, stroke, and depression. Gut microbiota has been affirmed to interact with various organs, ...