Multi-Omics and Machine Learning Integration Identifies Key Endothelial Modules in Carotid Artery Stenosis [0.03%]
多组学和机器学习联合识别颈动脉狭窄内皮关键模块
Jiayi Wu,Chunguang Guo,Linfeng Zhang et al.
Jiayi Wu et al.
Background: Carotid artery stenosis (CAS) is a major cause of ischemic stroke, yet reliable molecular biomarkers for early identification remain limited. ...
Performance Evaluation of a Premier Resolution HPLC System for Detecting Hemoglobin Constant Spring, Hemoglobin Paksé, and Coexisting α- and β-Thalassemia Mutations [0.03%]
高效液相色谱系统检测血红蛋白 constant spring、血红蛋白 paksé 及合并α-β地中海贫血突变的性能评价
Surada Satthakarn,Wibhasiri Srisuwan,Sitthichai Panyasai
Surada Satthakarn
Background: Hemoglobin Constant Spring (HbCS) and Hb Paksé are clinically significant α-globin variants prevalent in Southeast Asia that cause severe non-deletional HbH disease when combined with α0-thalassemia deletio...
Assessment of Dried Plasma Spots (DPS) as an Appropriate Sample Matrix for the Measurement of Circulating Calretinin, a Biomarker for Mesothelioma-A Proof-Of-Concept Study [0.03%]
评估干血浆点（DPS）作为循环型钙网蛋白的合适样品基质用于间皮瘤生物标志物检测的概念验证研究
Jan Gleichenhagen,Nina Kaiser,Thomas Brüning et al.
Jan Gleichenhagen et al.
Background: Microsampling using filter cards for dried blood spots (DBS) and dried plasma spots (DPS) is a well-established technique offering practical advantages for blood collection and subsequent processing. For DBS/D...
In Silico Fragment Size Selection for Enhanced Fetal Fraction and Abnormality Origin Discernment Using Pair-End Sequencing of Maternal Plasma DNA [0.03%]
基于母体血浆DNA配对末端测序的胎儿片段大小选择以提高胎儿分数及异常来源识别率的全基因组数值子拷贝数变异检测方法研究
Lihui Yang,Jiutong Zhang,Ji Zhang et al.
Lihui Yang et al.
Objectives: The aim of this study was to develop and evaluate a new bioinformatics pipeline that improves fetal DNA fraction (FF), determines the origin of chromosomal abnormalities, and better detects sex chromosomal ane...
Retrospective Identification and Quantitative Image Analysis of the ICAP Nuclear Pattern AC-30 in Antinuclear Antibody Testing [0.03%]
抗核抗体检测中ICAP模式AC-30的回顾性识别与定量图像分析
Changmeng Wu,Wenhan Du,Weidong Chen et al.
Changmeng Wu et al.
Background: The International Consensus on ANA Patterns (ICAP) recently codified the AC-30 nuclear pattern, characterized by fine speckled nuclear texture and metaphase chromatin staining. Although formally recognized, it...
COL1A1+ Epithelial Cells Orchestrate VEGFA-VEGFR Signaling in Endometritis Revealed by Single-Cell Analysis [0.03%]
单细胞分析揭示COL1A1+上皮细胞在子宫内膜炎中调控VEGFA-VEGFR信号通路
Chengzi Tian,Zaiyi Li
Chengzi Tian
Background: Endometritis is linked to adverse reproductive outcomes, but epithelial programs in disease initiation and persistence remain unclear. We aimed to systematically define inflammation-associated epithelial state...
Performance Evaluation of Automated Urit 5160 Haematology Analyser at the Bamenda Regional Hospital, Cameroon [0.03%]
喀麦隆巴姆enda地区医院Urit 5160血液分析仪的性能评估
Victor N Fondoh,Loveline L Niba,Mary B Atanga
Victor N Fondoh
Background: The Urit 5160 is a five-part leucocyte automated haematology analyser routinely used to improve workflow, patient management, and research. It is essential to confirm the instrument's performance by examining ...
Calreticulin Type 26 Mutation in Myelofibrosis: A Rare Variant With Diagnostic Challenges [0.03%]
巨核细胞纤维化病的钙网蛋白型26变异：具有诊断挑战性的罕见变异型
Teresa Maltese,Giuseppina Raffa,Fabio Stagno et al.
Teresa Maltese et al.
Background: Myeloproliferative neoplasms (MPNs) are clonal hematologic disorders commonly driven by mutations in JAK2, MPL, or CALR. Because routine CALR assays are largely optimized for the canonical Type 1 and Type 2 ex...
Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma [0.03%]
鼻咽癌中MMP1和TGFBR2的分子功能及药物预测研究
Feng Wang,Binbin Ge,Ming Li et al.
Feng Wang et al.
Background: Nasopharyngeal carcinoma (NPC) is partially driven by epithelial-mesenchymal transition (EMT). We identified potential EMT-related biomarkers and targeted drugs for NPC via computational and machine learning a...
Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study [0.03%]
基于遗传关联研究的浆液性卵巢癌中炎症细胞因子和脂质代谢物间的因果互作关系
Chong-Ze Yang,Lan-Hui Qin,Cheng-Can Huang et al.
Chong-Ze Yang et al.
Background: The causal roles and interactions of inflammatory cytokines and metabolic reprogramming in serous ovarian carcinoma (SOC) remain unclear. This study explored their relationships using Mendelian randomization (...