Integrating Prostate-Specific Antigen Density and Prostate Imaging Reporting and Data System Scores to Optimize Detection of Clinically Significant Prostate Cancer: A Multivariable Risk Model Approach [0.03%]
基于多变量风险模型的前列腺特异性抗原密度与前列腺影像报告和数据系统评分整合优化检测临床显著性前列腺癌的研究
Yunus Kayali
Yunus Kayali
Background: Prebiopsy multiparametric MRI (mpMRI) reported using the Prostate Imaging Reporting and Data System (PI-RADS) improves prostate cancer triage, yet false-positive findings remain common and may drive unnecessar...
Evaluation of FilmArray Multiplex PCR Test Results in Bloodstream Infections in Oncological Patients [0.03%]
评估FilmArray多重PCR检测在肿瘤患者血流感染中的应用价值
İpek Mumcuoğlu,Sevgi Şahin,Esra Tavukcu et al.
İpek Mumcuoğlu et al.
Background: Rapid identification of microorganisms and resistance genes in positive blood cultures may help optimize early antibiotic therapy and improve outcomes. In this study, we compared the BioFire FilmArray Blood Cu...
Asprosin as a Potential Link Between Vascular Inflammation and Disease Activity in Behçet's Disease [0.03%]
阿斯普洛辛作为贝赫切特病血管炎症与疾病活动之间的潜在联系
Zeynep Kaya,Mesude Seda Aydogdu,Cihat Ucar et al.
Zeynep Kaya et al.
Objective: Behçet's disease (BD) is a chronic multisystem vasculitis characterized by endothelial dysfunction and vascular inflammation. Asprosin is a recently identified adipokine implicated in endothelial injury and pr...
Large-Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management [0.03%]
大规模评估传统中药发现治疗二型糖尿病的PPARγ调节剂潜力
Mingyuan Dou,Shandra Jones,Juan Montes et al.
Mingyuan Dou et al.
Background: Peroxisome proliferator-activated receptor-gamma (PPARγ) is a pivotal nuclear receptor regulating glucose and lipid homeostasis, making it a primary therapeutic target for type 2 diabetes mellitus (T2DM). Des...
Molecular and Clinical Characterization of the Hb Tübingen [β106(G8) Leu→ Gln, HBB: c.320 T>A] Associated With Congenital Methemoglobinemia in a Chinese Family [0.03%]
中国一家族先天性高铁血红蛋白症的分子及临床特征研究——Tübingen突变(Hb Tübingen [β106(G8) Leu→ Gln, HBB: c.320 T>A])
Hualei Luo,Zhenmin Ren,Yuhua Ye et al.
Hualei Luo et al.
Background: Congenital methemoglobinemia caused by hemoglobin variants is a rare hematological disorder often misdiagnosed due to overlapping features with enzymatic defects. Hb Tübingen, a β-globin chain variant (βCD1...
From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development [0.03%]
从DNA甲基化微阵列到数字PCR：组织特异性cfDNA生物标志物开发的逐步策略
David H Murray,Nicky Boulter,Shanon Ranjit et al.
David H Murray et al.
Background: Tissue-specific cell-free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury. However, current methods for cfDNA tissue-of-origin analysis often depend on genome-wide sequencing appro...
UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications [0.03%]
UGT1A1 片段分析：临床应用中的(TA)n可变重复多态性基因分型
Ryan N Baugher,Kristen M Pike,Teri M Plona et al.
Ryan N Baugher et al.
Background: UGT1A1 is involved in glucuronidation of drugs and plays a large role in metabolism. Genotyping variants of differing dinucleotide TA repeat length within the TATA box of the UGT1A1 region (dbSNP ID rs3064744)...
Development of a Novel UPC (Urine Red Blood Cell Distribution, Proteinuria, and Serum Creatinine) Index to Differentiate Glomerular from Nonglomerular Hematuria [0.03%]
新型UPC（尿红细胞分布、蛋白尿和血清肌酐）指数的建立，用于鉴别非肾小球性血尿和肾小球性血尿
Hae In Bang,Sun Min Lee,In Hee Lee et al.
Hae In Bang et al.
Background: Urine red blood cell distribution (URD), defined as the percentage of small RBC fractions measured by the Sysmex UF-5000 analyzer, demonstrates diagnostic accuracy comparable to dysmorphic RBC analysis for dis...
Comparative Analysis of Four Matrix Dilution Methods for Eliminating IgM Paraprotein Interference in Prealbumin and Uric Acid Assays: Based on Two Case Reports [0.03%]
四种矩阵稀释法排除IgM型本周蛋白干扰前白蛋白和尿酸测定的对比分析——基于2例报告
Xiaowei Chi,Zihan Liu,Weifang Liu et al.
Xiaowei Chi et al.
Background: IgM paraproteins frequently cause spurious results in biochemical assays; however, standardized strategies to eliminate such interference remain limited. This study systematically compares four dilution matric...
Multi-Omics Profiling Uncovers Predictive Factors for Tumor-Infiltrating Lymphocyte Therapy in Ovarian Cancer [0.03%]
多组学谱型分析发现卵巢癌肿瘤浸润淋巴细胞疗法的预测因素
Xiuzhen Wang,Rui Hou,Jinguo Chen et al.
Xiuzhen Wang et al.
Background: Ovarian cancer (OC) remains a challenging malignancy with a poor prognosis, particularly in advanced stages. Tumor-infiltrating lymphocyte (TIL) therapy shows promise but has yielded inconsistent results in OC...