Decoding Sugars: Mass Spectrometric Advances in the Analysis of the Sugar Alphabet [0.03%]
解码糖类：分析糖类字母表的质量光谱法进展
Jitske M van Ede,Dinko Soic,Martin Pabst
Jitske M van Ede
Monosaccharides play a central role in metabolic networks and in the biosynthesis of glycomolecules, which perform essential functions across all domains of life. Thus, identifying and quantifying these building blocks is crucial in both re...
Thermometer Ions, Internal Energies, and In-Source Fragmentation in Ambient Ionization [0.03%]
thermometer离子、内能和大气压下离子源碎片化
Emilie Bertrand,Valérie Gabelica
Emilie Bertrand
Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in-source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal en...
MS-Based Glycome Characterization of Biotherapeutics With N- and O-Glycosylation [0.03%]
基于质谱技术的生物治疗药物糖型分析
Myung Jin Oh,Youngsuk Seo,Nari Seo et al.
Myung Jin Oh et al.
With the increasing FDA approvals of glycoprotein-based biotherapeutics including monoclonal antibodies, cytokines, and enzyme treatments, the significance of glycosylation in modulating drug efficacy and safety becomes central. This review...
Unlocking the Secrets of Insects: The Role of Mass Spectrometry to Understand the Life of Insects [0.03%]
揭秘昆虫世界：质谱技术助力昆虫研究
Vanessa Mayorga-Martino,Madina Mansurova,Erika Calla-Quispe et al.
Vanessa Mayorga-Martino et al.
Chemical signaling is crucial during the insect lifespan, significantly affecting their survival, reproduction, and ecological interactions. Unfortunately, most chemical signals insects use are impossible for humans to perceive directly. He...
Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry [0.03%]
结合直接电离和大气压电离的质谱的电动操控技术
Nicholas E Manicke,Lahiru Wedasingha,Magnus Rydberg
Nicholas E Manicke
Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separ...
Szu-Hsueh Lai,Sylvain Maclot,Rodolphe Antoine et al.
Szu-Hsueh Lai et al.
Single particle mass analysis methods allow the measurement and characterization of individual nanoparticles, viral particles, as well as biomolecules like protein aggregates and complexes. Several key benefits are associated with the abili...
Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome [0.03%]
质谱在评估反应性化学污染物暴露中的核心作用：从暴露组学到加合物组学
Laurent Debrauwer,Loic Mervant,Olivier Laprevote et al.
Laurent Debrauwer et al.
A large part of the Human chemical exposome is now well characterized, and its health effects has been widely documented, although precise causal links remain difficult to establish. In parallel, genetic factors only were shown to contribut...
Wout Bittremieux,Varun Ananth,William E Fondrie et al.
Wout Bittremieux et al.
Protein tandem mass spectrometry data are most often interpreted by matching observed mass spectra to a protein database derived from the reference genome of the sample being analyzed. In many application domains, however, a relevant protei...
Recent Advancements in the Characterization of D-Amino Acid and Isoaspartate Post-Translational Modifications [0.03%]
D-氨基酸和异天冬氨酸翻译后修饰表征的最新进展
Samuel Okyem,Jonathan V Sweedler
Samuel Okyem
One of the great triumphs of mass spectrometry-based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not cha...
Xiaokang Guan,Qiao Lu,Shuxian Liu et al.
Xiaokang Guan et al.
Mass spectrometry imaging (MSI) technologies are widely used today to study the in situ spatial distributions for a variety of analytes. As these technologies advance, the pursuit of higher resolution in MSI has intensified. The limitation ...