Benjamin A Garcia
Benjamin A Garcia
First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique [0.03%]
轨道离子阱质量分析技术作为主要分析手段的前二十年历程与发展
Alexander Makarov
Alexander Makarov
This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument f...
Jada N Walker,Jennifer S Brodbelt
Jada N Walker
Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top-down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alt...
Li Ding,Lulu Sun,Weimin Wang
Li Ding
The digital ion trap (DIT) is an ion trap in which the periodic trapping field is driven by digital signals-typically with a rectangular waveform-generated by fast-switching circuits. This paper reviews the research history of rectangular w...
The TriVersa NanoMate: Automation of Nano Electrospray Analyses [0.03%]
TriVersa NanoMate：纳喷分析的自动化技术
Simon Prosser,Gary Schultz,Thomas Corso et al.
Simon Prosser et al.
The evolution of nano-electrospray ionization technology began in the mid-1980s. At that time, no commercial vendors supplied the requisite electrospray emitters, which featured internal diameters of just a few microns. Tips were manually f...
Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox-Driven Pathology [0.03%]
硝基酪氨酸的蛋白质组学：在氧化还原驱动病理中的质谱和免疫检测整合
Brîndușa Alina Petre
Brîndușa Alina Petre
Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3-nitrotyrosine (3NT) has emerged as a biologically relevant mar...
Hilkka Kenttämaa
Hilkka Kenttämaa
Renato Zenobi
Renato Zenobi
Data-Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research [0.03%]
数据非依赖性采集质谱在肿瘤分类和癌症生物标志物研究中的应用
Jan Simonik,Petr Lapcik,Pavla Bouchalova et al.
Jan Simonik et al.
Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide ...
Recent Advances in On-Tissue Chemical Derivatization Strategies for Enhancing MALDI-MSI [0.03%]
用于增强MALDI-MSI的组织化学衍生化策略的最新进展
Meng Huang,Xiaoyu Qi,Dafu Zhu et al.
Meng Huang et al.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has rapidly advanced in biomedical research, enabling label-free, untargeted spatial detection of metabolites, lipids, proteins, and glycans in tissue section...