The Rise of Top-Down Mass Spectrometry for the Characterization of Oligonucleotide Therapeutics [0.03%]
基于寡核苷酸疗法表征的自上而下质谱研究进展
Molly S Blevins,Christopher M Crittenden,Bifan Chen
Molly S Blevins
The therapeutic landscape has been rapidly expanding beyond traditional small molecules and biologics in recent years with the emergence of oligonucleotide therapeutics. As these oligonucleotide modalities grow in complexity and chemical mo...
Comprehensive Tutorial for Computational Methods of Protein Structure Prediction Incorporating Mass Spectrometry Data [0.03%]
结合质谱数据的蛋白质结构预测计算方法综合教程
Zachary C Drake,Robert M Bolz,Elijah H Day et al.
Zachary C Drake et al.
Here we present a series of tutorials demonstrating the use of various methods which integrate structural mass spectrometry (MS) data with computational protein structure prediction methods. We give usage examples of widely used modeling fr...
Mass Spectrometry Insights Into Post-Translational Modifications in Extracellular Vesicles [0.03%]
质谱揭示细胞外囊泡中蛋白修饰的奥秘
Dávid Virág,Krisztián Márk Karvaly,Alexandra Molnár et al.
Dávid Virág et al.
Extracellular vesicles (EVs) are membrane-enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest ...
Standardization Challenges and Breakthroughs in Apolipoprotein B Detection: From Immunoassays to LC-MS/MS [0.03%]
载脂蛋白B检测的标准难题与突破：从免疫测定到液相色谱-串联质谱法
Anqi Pan,Haijian Zhao,Jing Wang et al.
Anqi Pan et al.
Apolipoprotein B (apoB) is a key biomarker for risk assessment and treatment monitoring of atherosclerotic cardiovascular disease (ASCVD). Its clinical value has been validated by multiple studies, and its predictive performance for ASCVD r...
The Rise of Trapped Ion Mobility Spectrometry: Principles, Applications, and Recent Developments [0.03%]
陷阵营离子漂移谱学的研究进展：原理、应用及 recent developments
Erin M Panczyk,Claudia Martelli,Mark E Ridgeway et al.
Erin M Panczyk et al.
Trapped ion mobility spectrometry (TIMS) is a highly versatile alternative to the more conventional drift tube ion mobility spectrometer (DTIMS). In TIMS, ions are analyzed using an electric field that holds ions stationary against moving g...
Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up [0.03%]
卡尔托·莱布拉利亚：从零开始建立仪器、学科和机遇
Benjamin A Garcia
Benjamin A Garcia
Jake A Melby,Pei Su,Fabio P Gomes
Jake A Melby
Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single-cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization ...
Morgan W Mann,Priscilla S-W Yeung,Ruben Y Luo
Morgan W Mann
This review evaluates the applications of top-down mass spectrometry (TDMS) and intact mass measurement of proteins in clinical laboratories. Both methods involve the measurement of intact proteins in a mass spectrometer without the use of ...
Recent Advances (2023-2025) of Capillary Electrophoresis-Mass Spectrometry (CE-MS) for Top-Down Proteomics [0.03%]
CE-MS在鸟枪法蛋白质组学中的最新进展（2023-2025）
Guijie Zhu,David A Alvarez Rodriguez,Noah Gould et al.
Guijie Zhu et al.
Top-down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform ...
Benjamin A Garcia
Benjamin A Garcia