Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data [0.03%]
雌激素受体alpha基因(ESR1)多态性与抑郁症的性别特异性关联：对All of Us和UK生物库数据的全基因组关联研究
Yue Hu,Menglu Che,Heping Zhang
Yue Hu
Major depressive disorder (MDD) is prevalent worldwide, substantially and negatively impacting both the quality and length of life of 280 million people globally. The genetic risk factors of MDD have been studied in various previous researc...
Reference-Based Standardization Approach Stabilizing Small Batch Risk Prediction via Polygenic Score [0.03%]
基于参考的多基因得分稳定小样本风险预测标准方法
Yoichi Sutoh,Tsuyoshi Hachiya,Yayoi Otsuka-Yamasaki et al.
Yoichi Sutoh et al.
The polygenic score (PGS) holds promise for motivating preventive behavioral changes. However, no clinically validated standardization methodology currently exists. Here, we demonstrate the efficacy of a "reference-based" approach for stand...
RetroFun-RVS: A Retrospective Family-Based Framework for Rare Variant Analysis Incorporating Functional Annotations [0.03%]
具有功能注释的罕见变异分析的回顾性家族框架RetroFun-RVS
Loïc Mangnier,Ingo Ruczinski,Jasmin Ricard et al.
Loïc Mangnier et al.
A large proportion of genetic variations involved in complex diseases are rare and located within noncoding regions, making the interpretation of underlying biological mechanisms a daunting task. Although technical and methodological progre...
Gene-Air Pollution Interaction and Diversity of Genetic Sampling: The Southern California Children's Health Study [0.03%]
儿童基因-空气污染交互作用及遗传多样性取样：一项关于南加州儿童健康的研究
Justine Po,John Morrison,Brittney Marian et al.
Justine Po et al.
Gene-environment interactions have been observed for childhood asthma, however few have been assessed in ethnically diverse populations. Thus, we examined how polygenic risk score (PRS) modifies the association between ambient air pollution...
A Novel Statistical Method for Unmasking Sex-Specific Genomics Signatures in Complex Traits [0.03%]
一种新的统计方法，用于揭示复杂性状中性别特异性的基因组标志
Samaneh Mansouri,Mélissa Rochette,Benoit Labonté et al.
Samaneh Mansouri et al.
Genotype-phenotype association studies have advanced our understanding of complex traits but often overlook sex-specific genetic signals. The growing awareness of sex-specific influences on human traits and diseases necessitates tailored st...
Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids [0.03%]
基于遗传预测的基因表达对红细胞和血浆中多不饱和脂肪酸变化的影响
Nikhil K Khankari,Timothy Su,Qiuyin Cai et al.
Nikhil K Khankari et al.
Polyunsaturated fatty acids (PUFAs) including omega-3 and omega-6 are obtained from diet and can be measured objectively in plasma or red blood cells (RBCs) membrane biomarkers, representing different dietary exposure windows. In vivo conve...
Identifying Disease Associated Multi-Omics Network With Mixed Graphical Models Based on Markov Random Field Model [0.03%]
基于马尔可夫随机场模型的混合图模型在多组学关联疾病网络中的应用
Jaehyun Park,Sungho Won
Jaehyun Park
In this article, we proposed a new method named fused mixed graphical model (FMGM), which can infer network structures associated with dichotomous phenotypes. FMGM is based on a pairwise Markov random field model, and statistical analyses i...
General Kernel Machine Methods for Multi-Omics Integration and Genome-Wide Association Testing With Related Individuals [0.03%]
具有相关性的个体的多组学整合和全基因组关联分析的广义核机器方法
Amarise Little,Ni Zhao,Anna Mikhaylova et al.
Amarise Little et al.
Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a chall...
Multivariable MR Can Mitigate Bias in Two-Sample MR Using Covariable-Adjusted Summary Associations [0.03%]
多重变量MR可以通过协变量调整的汇总关联来减轻使用两个样本MR中的偏差
Joe Gilbody,Maria Carolina Borges,George Davey Smith et al.
Joe Gilbody et al.
Genome-wide association studies (GWAS) are hypothesis-free studies that estimate the association between polymorphisms across the genome with a trait of interest. To increase power and to estimate the direct effects of these single-nucleoti...
Transferability of Single- and Cross-Tissue Transcriptome Imputation Models Across Ancestry Groups [0.03%]
单组织和跨组织转录组预测模型在不同人群中的迁移性研究
Inti Pagnuco,Stephen Eyre,Magnus Rattray et al.
Inti Pagnuco et al.
Transcriptome-wide association studies (TWAS) investigate the links between genetically regulated gene expression and complex traits. TWAS involves imputing gene expression using expression quantitative trait loci (eQTL) as predictors and t...