Hidden Markov Model-Based Behavioral Classification Reveals Visual Function Recovery After Retinal Organoid Transplantation in Mice [0.03%]
基于隐马尔可夫模型的行为分类揭示了移植视网膜器官oids后的视觉功能恢复情况
Hironobu Shuto,Michiko Mandai,Takayuki Yamada et al.
Hironobu Shuto et al.
Retinal degenerative diseases cause irreversible vision loss due to photoreceptor degeneration. Retinal organoid transplantation offers a promising strategy for restoring vision, but assessing functional recovery remains challenging. Standa...
Altered Effective Connectivity of the Numerical Brain in Children With Developmental Dyscalculia [0.03%]
发育性算术障碍儿童大脑数值加工有效连接的改变
Simone Schwizer Ashkenazi,Ursina McCaskey,Ruth O&#x;Gorman Tuura et al.
Simone Schwizer Ashkenazi et al.
Numerical-order ability, a strong predictor of arithmetic, is often impaired in children with developmental dyscalculia (DD). While previous research has shown altered brain responses in number-processing regions in DD compared to typically...
Piano Training Induces Dynamic Neuroplasticity of Bimanual Coordination but Not Auditory Processing in Young Adults [0.03%]
钢琴训练能够动态增强成年人的双手协调能力但不能改善听觉处理能力
Alicja M Olszewska,Maciej Gaca,Dawid Droździel et al.
Alicja M Olszewska et al.
Piano training enables the study of the interplay between the auditory and motor domains in the acquisition of complex skill. Here, we uniquely combine longitudinal and cross-sectional designs to show how the motor and auditory brain system...
Peripheral Nerve Repair: Historical Perspectives, Current Advances, and Future Directions in Natural and Synthetic Neural Conduits [0.03%]
外周神经修复：天然和合成神经导管的历史、现状及未来方向
Tayebeh Sadat Tabatabai,Morteza Alizadeh,Mohammad Kamalabadi Farahani et al.
Tayebeh Sadat Tabatabai et al.
Regenerative medicine aims to restore damaged tissues or organs using stem cells, biomaterials, and decellularized grafts. Peripheral nerve injuries (PNI), affecting 2.8% of patients, lead to severe functional impairments with global socioe...
Curcumin Prevents Neuronal Loss and Inhibits Development of Spontaneous Recurrent Seizures via the PPARγ/PTEN/Akt Pathway in Chronic Epilepsy [0.03%]
姜黄素通过PPARγ/PTEN/Akt通路预防神经元丢失并抑制慢性癫痫中自发性复发性惊厥的发展
Sun Hong,Liu GuoYan,Wu JiaWen et al.
Sun Hong et al.
Chronic epilepsy is mainly characterized by spontaneous recurrent seizures (SRS). The peroxisome proliferator activated receptor gamma/phosphatase and tensin homolog/protein kinase B (PPARγ/PTEN/Akt) pathway is involved in the pathogenesis...
P2X7R: A Critical Regulator and Potential Therapeutic Target for Glioma [0.03%]
P2X7受体：胶质瘤的关键调控因子和潜在治疗靶点
Meng Yan,Ronglan Zhao,Yanwen Xue et al.
Meng Yan et al.
Glioma is the most common primary brain tumor, characterized by high invasiveness and poor prognosis. The purinergic ligand-gated ion channel 7 receptor (P2X7R), an ion channel-type purinergic receptor with adenosine triphosphate (ATP) as i...
Unveiling the Neural Pathways of Empathic Pain: Implications for Modulation Strategies and Beyond [0.03%]
揭开共鸣疼痛的神经通路：调节策略及展望
Yingying Zhang,Kun Zhang,Hengxin Gong et al.
Yingying Zhang et al.
Empathic pain, a core manifestation of empathy, encompasses an individual's perceptual sensitivity, evaluative judgment, and emotional responsiveness to the suffering of others. This capacity is vital for healthy social interaction, as it f...
Single-Neuron Discharges Correlating High-Frequency Oscillations Dynamics in Epileptogenesis and Epilepsy Development [0.03%]
癫痫发生和癫痫发作过程中单神经元放电与高频振荡动力学相关性研究
Xiaonan Li,Shipei He,Jiaoyang Wang et al.
Xiaonan Li et al.
The mechanism of epilepsy is still unclear. We aim to explore the relationship between high-frequency oscillations (HFOs) dynamics and epilepsy, with a focus on deciphering underlying mechanisms at the single-neuron level. Using a rat model...
Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells [0.03%]
lanthionine ketimine乙酯诱导原代小鼠少突胶质前体细胞增殖、成熟及钙离子流的变化
Veronica T Cheli,Swathi G Tumuluri,Zachary McDonald et al.
Veronica T Cheli et al.
Previous studies have shown that lanthionine ketimine ethyl ester (LKE), a semi-synthetic derivative of the endogenous amino acid lanthionine, can induce proliferation and maturation of oligodendrocyte progenitor cells (OPCs) in vivo. In th...
Characteristics and Changes of Cingulate Gyrus Function and Perfusion in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis [0.03%]
抗N-甲基-D-天冬氨酸受体脑炎患者扣带回功能与灌注特征及变化规律研究
Yuanyuan Guo,Yue Zhao,Chenglong Li et al.
Yuanyuan Guo et al.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune condition associated with neuropsychiatric and cognitive deficits. Changes in the cingulate cortex may be central to this disorder. This study investigates subregional...