CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma [0.03%]
利用CRISPR筛选技术鉴定PIK3C2A为头颈部鳞状细胞癌表皮生长因子受体抑制剂耐药的新调节因子
Jiayu Wang,Megan L Ludwig,Aditi Kulkarni et al.
Jiayu Wang et al.
Background: Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and survival. While epidermal growth factor receptor (EGFR) is a known driver of HNSCC, EGFR inhibitors show limited efficacy a...
Clinical Outcomes of Radiologically Node-Negative Oropharyngeal Squamous Cell Carcinoma: A Retrospective Analysis [0.03%]
放射学检查未见淋巴结转移的口腔鳞状细胞癌患者预后回顾性分析
Mohamed Elmarghani,Panagiotis Asimakopoulos,Mathew Donachie et al.
Mohamed Elmarghani et al.
Background: Oropharyngeal squamous cell carcinoma (OPSCC) shows distinct clinical patterns based on HPV status. In the UK, rising HPV-positive cases have changed the disease's demographics and prognosis. While nodal invol...
Single Port Robot-Assisted Supraclavicular Flap Repair of Iatrogenic Hardware-Associated Pharyngeal Perforation: A Case Report [0.03%]
单孔机器人协助锁骨上皮瓣修复医源性咽喉器械穿孔：病例报告
Febronia Morcos Mansour,Mark Marzouk
Febronia Morcos Mansour
Background: The incidence of iatrogenic pharyngeal perforation has been reported to comprise 50%-75% of all pharyngeal perforations. In the context of anterior cervical diskectomy and fusion (ACDF) procedures, pharyngeal ...
Case Reports
Head & neck. 2025 Sep 16. DOI:10.1002/hed.70041 2025
Comparing Functional Outcomes Following TORS With Free Flap Reconstruction Using a Radial Forearm vs. Anterolateral Thigh Flap [0.03%]
经口机器人手术后采用桡动脉前臂皮瓣和股外侧皮瓣游离皮瓣重建的功能预后比较研究
Praneet Kaki,Doreen Lam,Neel R Sangal et al.
Praneet Kaki et al.
Background: Free flap reconstruction (FFR) following transoral robotic surgery (TORS) is commonly performed using radial forearm free flaps (RFFF). This study compares patterns of functional recovery between RFFFs and ant...
Prognosis After Discontinued Treatment due to Immune-Related Adverse Events in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma [0.03%]
头颈鳞状细胞癌免疫相关不良事件导致停药后的预后研究
Hiromasa Ishihara,Yuki Asahi,Masashi Kuroki et al.
Hiromasa Ishihara et al.
Background: The prognostic impact of immune-related adverse events (irAEs) in recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC) remains unclear, particularly after treatment discontinuation. ...
Predictive Nomogram for Risk Stratification After Transoral Surgery in HPV-Related Oropharyngeal Cancer [0.03%]
基于 nomogram 的 HPV 相关型喉癌经口手术后预后分层预测模型
Andrea Costantino,Vinidh Paleri,F Christopher Holsinger et al.
Andrea Costantino et al.
Background: This study develops a predictive model that stratifies patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) by survival outcomes based on adjuvant treatment received following transoral surg...
Hypoglossal Neuropathy in the Pathogenesis of Fibrosis-Related Late-Radiation Associated Dysphagia: A Correlative Analysis Utilizing Electromyography to Explore the Frequency of Clinical and Subclinical Neuropathy in a Pilot Dysphagia Trial [0.03%]
舌下神经病在放射性食管纤维化相关晚期吞咽困难发病机制中的作用：一项针对吞咽困难的探索临床和亚临床神经病频率的电生理研究的相关分析（ pilot 研究）
Holly McMillan,Christine Okoro,Sheila Buoy et al.
Holly McMillan et al.
Background: Late radiation-associated dysphagia (late-RAD) commonly presents in patients with signs of hypoglossal neuropathy, with hallmark clinical features including lingual atrophy, deviation, and fasciculation. Gold-...
Transoral Robotic Surgery (TORS) Versus Open Surgery for Recurrent Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis [0.03%]
复发性口咽鳞癌经口机器人手术与开放手术的系统评价和 meta 分析
Francisco Laxague,Drosa Zabihi-Pour,Claudia C Correa Roa et al.
Francisco Laxague et al.
Background: Salvage surgery (SS) is one of the best treatment options for recurrent oropharyngeal squamous cell carcinoma (OPSCC) after prior definitive radiation. ...
Neoadjuvant Chemotherapy Followed by Surgery-A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer [0.03%]
新辅助化疗联合手术治疗有望成为减少局部晚期舌癌术后并发症的策略
G A Deshpande,S Rai,A Singh et al.
G A Deshpande et al.
Background: Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain. Methods: ...
Flap Complications Following Maxillectomy, Reconstructive Surgery, and Postoperative Proton Radiotherapy: A Cohort Study and Considerations for Risk Mitigation [0.03%]
上颌切除、重建手术和术后质子放射治疗后的并发症：一项队列研究及风险降低的考虑因素
Amir H Safavi,Fan Yang,Yingzhi Wu et al.
Amir H Safavi et al.
Background: Flap complications following maxillectomy, reconstruction, and adjuvant proton beam therapy (PBT) for primary maxillary and sinonasal malignancies are not well described. ...