Editorial highlights [0.03%]
主编手记
Paul A Trainor
Paul A Trainor
Fumiya Meguro,Katsushige Kawasaki,Yoshito Kakihara et al.
Fumiya Meguro et al.
Background: Genomes are constantly exposed to a myriad of DNA-damaging agents. Robust DNA repair mechanisms protect DNA by removing or tolerating damage. However, it remains unclear whether these mechanisms are required f...
Streamlining asymmetry quantification in fetal mouse imaging: A semi-automated pipeline supported by expert guidance [0.03%]
基于专家指导的胎儿小鼠影像不对称量化半自动化流程的设计与实现
S M Rolfe,D Mao,A M Maga
S M Rolfe
Background: Asymmetry is a key feature of numerous developmental disorders and in phenotypic screens is often used as a readout for environmental or genetic perturbations. A better understanding of the genetic basis of as...
Differences in palatal shelf epithelial stiffness between the lingual/nasal and buccal/oral surfaces during palatal shelf elevation in developing mice [0.03%]
发育小鼠腭 Shelf 升高过程中舌侧/鼻侧和颊侧/口侧上皮硬度的差异
Arata Nagasaka,Yasuhiko Bando,Miyuki Toda-Fujii et al.
Arata Nagasaka et al.
Background: During secondary palate formation, bilateral palatal shelves grow vertically to a horizontal position. This morphological change of the palatal shelves, defined as the palatal shelf elevation, occurs from embr...
Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD [0.03%]
果蝇中肠道PSS敲低导致的生长迟缓与人类LMHD类似
Kwan-Young Kim,You-Lim Hwang,Sunwoo Yeom et al.
Kwan-Young Kim et al.
Background: Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz-Majewski hyperostotic dwarfism, a disorder affecting growth ...
Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos [0.03%]
Nipbl/CRL4轴下游的蛋白质周转参与斑马鱼胚胎发育异常
Annie C Sanchez,Niusha Banoukh,Fiona Mensching et al.
Annie C Sanchez et al.
Background: Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) r...
Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face [0.03%]
受体酪氨酸激酶信号通路的下游分支相互依存地塑造面部结构
Nicholas Hanne,Diane Hu,Marta Vidal-García et al.
Nicholas Hanne et al.
Background: Previously we found that increasing fibroblast growth factor (FGF) signaling in the neural crest cells within the frontonasal process (FNP) of the chicken embryo caused dysmorphology that was correlated with r...
The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl [0.03%]
内源大麻素系统调节尾巴切除后墨西哥钝头螈脑室上皮细胞和神经元的反应
Michael Tolentino,Sarah E Walker,Gaynor E Spencer et al.
Michael Tolentino et al.
Background: The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous s...
Vanessa Barone,Luisa Coronado,Deka Ismail et al.
Vanessa Barone et al.
Background: The use of the sea star Patiria miniata as a model system has produced groundbreaking advances in a disparate set of biomedical research fields, including embryology, immunology, regeneration, cell biology, an...
Therapeutic potential of stem cells in colorectal cancer management: Current trends and future prospects [0.03%]
干细胞在结直肠癌管理中的治疗潜力：当前趋势和未来前景
Manya D Desai,Namrata B Parmar,Isha T Shah et al.
Manya D Desai et al.
Colorectal cancer (CRC) ranks among the leading causes of cancer-related morbidity and mortality worldwide. Despite progress in understanding its molecular intricacies, the management of CRC, especially in advanced stages, remains a signifi...