Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis [0.03%]
外胚层Wnt通过调节BMP/FGF/JNK信号轴控制鼻孔形态发生
Xiao-Jing Zhu,Yudong Liu,Xueyan Yuan et al.
Xiao-Jing Zhu et al.
Background: Mutations of WNT3, WNT5A, WNT9B, and WNT11 genes are associated with orofacial birth defects, including nonsyndromic cleft lip with cleft palate in humans. However, the source of Wnt ligands and their signalin...
Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems [0.03%]
Müller胶质细胞依赖的神经视网膜再生：跨脊椎动物模型系统的综述
Annaïg Hamon,Jérôme E Roger,Xian-Jie Yang et al.
Annaïg Hamon et al.
Retinal dystrophies are a major cause of blindness for which there are currently no curative treatments. Transplantation of stem cell-derived neuronal progenitors to replace lost cells has been widely investigated as a therapeutic option. A...
Laura Ariza,Rita Carmona,Ana Cañete et al.
Laura Ariza et al.
Coelomic cavities of vertebrates are lined by a mesothelium which develops from the lateral plate mesoderm. During development, the coelomic epithelium is a highly active cell layer, which locally is able to supply mesenchymal cells that co...
Adrián Ruiz-Villalba,Stefan Hoppler,Maurice J B van den Hoff
Adrián Ruiz-Villalba
Wnt signaling plays an essential role in development and differentiation. Heart development is initiated with the induction of precardiac mesoderm requiring the tightly and spatially controlled regulation of canonical and noncanonical Wnt s...
Germ cells influence cord formation and Leydig cell gene expression during mouse testis development [0.03%]
生殖细胞影响小鼠睾丸发育过程中的连接结构形成和支持细胞基因表达
Clarissa Rios-Rojas,Cassy Spiller,Josephine Bowles et al.
Clarissa Rios-Rojas et al.
Background: It is widely accepted that, during the development of testes in the mammalian embryo, male germ cells are influenced by signals from the surrounding somatic cells, but not vice versa, so that germ cells are di...
Marta Linde-Medina,Benedikt Hallgrímsson,Ralph Marcucio
Marta Linde-Medina
The upper jaw in vertebrates forms from several prominences that arise around the stomodeum or primitive mouth. These prominences undergo coordinated growth and morphogenesis to fuse and form the face. Undirected, regionalized cell prolifer...
Bone mineralization-dependent craniosynostosis and craniofacial shape abnormalities in the mouse model of infantile hypophosphatasia [0.03%]
幼年低磷酸酶症小鼠模型中的骨矿化依赖性颅缝早闭和颅面形态异常
John Durussel,Jin Liu,Cassandra Campbell et al.
John Durussel et al.
Background: Inactivating mutations in tissue-nonspecific alkaline phosphatase (TNAP) cause hypophosphatasia (HPP), which is commonly characterized by decreased bone mineralization. Infants and mice with HPP can also devel...
Akiko Suzuki,Dhruvee R Sangani,Afreen Ansari et al.
Akiko Suzuki et al.
The morphogenesis of midfacial processes requires the coordination of a variety of cellular functions of both mesenchymal and epithelial cells to develop complex structures. Any failure or delay in midfacial development as well as any abnor...
Cardiomyocyte differentiation from mouse embryonic stem cells using a simple and defined protocol [0.03%]
一种简单的心肌细胞分化的小鼠胚胎干细胞体系
Ioannis Kokkinopoulos,Hidekazu Ishida,Rie Saba et al.
Ioannis Kokkinopoulos et al.
Background: Embryonic stem (ES) cells are pluripotent cells with the ability to differentiate to any cell type of the resident organism. In recent years, significant advances have been made in using these cells to obtain ...
K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds [0.03%]
新生小鼠角膜上皮早期存在K14+复合生态位，并在去角质伤口后扩增
Ahdeah Pajoohesh-Ganji,Sonali Pal-Ghosh,Gauri Tadvalkar et al.
Ahdeah Pajoohesh-Ganji et al.
Background: We previously identified compound niches (CNs) at the limbal:corneal border of the mouse cornea that contain corneal epithelial progenitor cells, express Keratin 8 (K8), and goblet cell mucin Muc5AC. During re...