Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development [0.03%]
在整个小鼠肺发育过程中内皮细胞和间充质细胞中初级纤毛的动态变化
Stephen Spurgin,Ange Michelle Nguimtsop,Fatima N Chaudhry et al.
Stephen Spurgin et al.
Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their...
Human stem cell model of neural crest cell differentiation reveals a requirement of SF3B4 in survival, maintenance, and differentiation [0.03%]
人类干细胞神经嵴细胞分化的模型揭示了SF3B4在生存、维持和分化中的需求
Casey Griffin,Jean-Pierre Saint-Jeannet
Casey Griffin
Background: In vitro modeling is a powerful approach to investigate the pathomechanisms driving human congenital conditions. Here, we use human embryonic stem cells (hESCs) to model Nager and Rodriguez syndromes, two cran...
Editorial highlights [0.03%]
编辑亮点
Paul A Trainor
Paul A Trainor
The synergistic link between sonic hedgehog signaling pathway and gut-lung axis: Its influential role toward chronic obstructive pulmonary disease progression [0.03%]
Sonic Hedgehog信号通路与肠肺轴的相互作用链接：其对慢性阻塞性肺疾病进展的影响作用
Nidhi Mahajan,Vishal Chopra,Kranti Garg et al.
Nidhi Mahajan et al.
Sonic Hedgehog (SHH) is an evolutionarily conserved signaling pathway essential for embryonic development, tissue homeostasis, and tumorigenesis. Aberrant activation of the SHH pathway induces various types of cancer and different types of ...
Jason C Mills,Nattapon Thanintorn,Yongjun Yin et al.
Jason C Mills et al.
Background: Fibroblast Growth Factor 9 (Fgf9) and its paralog Fgf20 are expressed in the developing stomach. We investigate the role of these growth factors during gastric development, using combinations of null alleles. ...
An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate [0.03%]
斑马鱼神经板浅表表面细胞的收缩和前伸行为的分析
Claudio Araya,Raegan Boekemeyer,Francesca Farlie et al.
Claudio Araya et al.
Background: The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial ...
Active cell proliferation contributes to the enlargement of the nascent nucleus pulposus [0.03%]
活跃的细胞增殖有助于新生椎间盘髓核的增大
Rose G Long,Changhee Lee,Clifford J Tabin
Rose G Long
Background: The notochord is an embryonic organ involved in forming and patterning the spinal column. The mechanism by which the notochord transforms from a continuous rod to a segmented structure excluded from the verteb...
Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish [0.03%]
上皮转录因子grhl3的丢失导致斑马鱼发育表型可变性渗透
Nishanthi Mathiyalagan,Travis K Johnson,Zachary Di Pastena et al.
Nishanthi Mathiyalagan et al.
Background: Environmental influence is critical for embryogenesis but is significantly under-appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report e...
β-Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function [0.03%]
栉水母Mnemiopsis leidyi中的β-连环蛋白定位提示其在细胞粘附和核功能中的祖先作用
Brian M Walters,Lucas J Guttieres,Mayline Goëb et al.
Brian M Walters et al.
Background: The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β-Catenin is signif...
Editorial highlights [0.03%]
编者按
Paul A Trainor
Paul A Trainor