Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling [0.03%]
通过GLP-1介导的肠关节轴治疗骨关节炎靶向肠道FXR信号转导
Yuanheng Yang,Cong Hao,Tingying Jiao et al.
Yuanheng Yang et al.
Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) in osteoarthritis. Suppressing farnesoid ...
Failure to communicate [0.03%]
沟通不力
Rebekah White
Rebekah White
Geoengineering could be crucial in the fight against climate change. But first scientists need to learn how to talk to the public about it.
Vaccine-enhanced competition permits rational bacterial strain replacement in the gut [0.03%]
疫苗增强的竞争允许肠道细菌菌株的理性替代
Verena Lentsch,Aurore Woller,Andrea Rocker et al.
Verena Lentsch et al.
Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or selected niche-competitor strains permit...
Qingsong Pan,Kunqing Ding,Song Guo et al.
Qingsong Pan et al.
Cyclic creep, or ratcheting, is a severe form of fatigue deformation caused by cumulative unidirectional plastic strain under asymmetrical stress cycling with a nonzero mean stress. It often causes premature failure of structural materials,...
Myeonghwan Kim,Youngjoon Pyo,Seong-In Hyun et al.
Myeonghwan Kim et al.
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens with in vitro-transcribed mRNAs in lipi...
Matthew J Ferrari,William J Moss
Matthew J Ferrari
Benchmarks must be established and progress tracked to set a global target and take action.
Taking flight [0.03%]
展翅飞翔
Melanie Ortiz Alvarez De La Campa
Melanie Ortiz Alvarez De La Campa
Catalysis at the crossroads [0.03%]
催化十字路口论催化
Cathy L Tway,Sorin V Filip
Cathy L Tway
Homogeneous and heterogeneous catalysis work concurrently in a chemical process.
Dancing with the cells: How acoustically levitating a diamond enabled a redesign of biotech automation [0.03%]
与细胞共舞：如何利用悬浮的钻石重新设计生物技术自动化
Luke Cox
Luke Cox
How acoustically levitating a diamond enabled a redesign of biotech automation.
Cathleen O&#x;Grady
Cathleen O&#x;Grady
Study is the first to show an animal combining different calls to make new meanings.