Hao Zhang,Lei Luo,Qiaoyi Liang et al.
Hao Zhang et al.
Taste is crucial in shaping animal perception. Sourness, one of the primary tastes, is aversive in mammals, whereas many birds frequently consume acidic fruits, suggesting a potential tolerance. Our study uncovers a mechanism enabling avian...
Cholinergic feedback for modality- and context-specific modulation of sensory representations [0.03%]
特异性和情境特定的感觉表征模态胆碱能反馈调制
Bin Yu,Yuxuan Yue,Chi Ren et al.
Bin Yu et al.
The brain's ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb (OB) circuits in mice. The activity of ...
Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome [0.03%]
释放因子介导的核糖体上肽基-tRNA水解机制
Elena V Aleksandrova,Egor A Syroegin,Ritwika S Basu et al.
Elena V Aleksandrova et al.
Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factors (RFs) that recognize stop codons and c...
Karen Allen,Peter B Armentrout,Clifford Berkman et al.
Karen Allen et al.
Raphael M Kudela
Raphael M Kudela
Shifts in phytoplankton populations could affect marine ecology and fisheries around the world.
Qiaomei Fu,Fan Bai,Huiyun Rao et al.
Qiaomei Fu et al.
Denisovans are a hominin group primarily known through genomes or proteins, but the precise morphological features of Denisovans remain elusive due to the fragmentary nature of discovered fossils. Here we report ninety-five endogenous prote...
Chen Wang,Anthony D Rish,Emily G Armbruster et al.
Chen Wang et al.
Retrons are antiphage defense systems that produce multicopy single-stranded DNA (msDNA) and hold promises for genome engineering. However, the mechanisms of defense remain unclear. The Retron-Septu system uniquely integrates retron and Sep...
Dipan Roy,Poonam Mehra,Lisa Clark et al.
Dipan Roy et al.
Reactive oxygen species function as key signals in plant adaptation to environmental stresses like drought. Roots respond to transient water unavailability by temporarily ceasing branching through the acclimative response xerobranching. In ...
Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation [0.03%]
连续两次碳碳键活化介导的酮基到硫基转换反应
Zining Zhang,Guangbin Dong
Zining Zhang
In drug development, replacement of a skeletal carbon with a sulfur atom can result in analogs of bioactive compounds with improved properties. Currently, the sulfur analogs are almost exclusively prepared by de novo synthesis; the existing...
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction [0.03%]
BBO-10203通过阻断RAS-PI3Kα相互作用抑制肿瘤生长而不引起高血糖症
Dhirendra K Simanshu,Rui Xu,James P Stice et al.
Dhirendra K Simanshu et al.
BBO-10203 is an orally available drug that covalently and specifically binds to the RAS-binding domain of phosphoinositide 3-kinase α (PI3Kα), preventing its activation by HRAS, NRAS, and KRAS. It inhibited PI3Kα activation in tumors wit...