Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans [0.03%]
mRNA编码纳米颗粒疫苗驱动人类广义中和抗体前体的早期成熟
Jordan R Willis,Madhu Prabhakaran,Michelle Muthui et al.
Jordan R Willis et al.
A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SHM) and produce bnAbs. In two randomized,...
Bacterial reverse transcriptase synthesizes long poly-A-rich cDNA for antiphage defense [0.03%]
细菌逆向转录酶合成长聚腺苷酸丰富的cDNA以防御噬菌体
Xin-Yi Song,Yushan Xia,Jun-Tao Zhang et al.
Xin-Yi Song et al.
Prokaryotic defense-associated reverse transcriptases (DRTs) were recently identified with antiviral functions; however, their functional mechanisms remain largely unexplored. Here we show that DRT9 forms a hexameric complex with its upstre...
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting [0.03%]
用于肠道微生物介导的药物靶向的定制植物糖缀合物
Wei Jen Ma,Changqing Wang,Jagatheeswaran Kothandapani et al.
Wei Jen Ma et al.
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on be...
Sandra Gómez-López,Ahmed S N Alhendi,Moritz J Przybilla et al.
Sandra Gómez-López et al.
Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we ...
Qinghao Cui,Lishuai Jin
Qinghao Cui
As rose petals change shape during maturation, they do not follow classical geometrical incompatibility.
J Trae Hampton,Wenshe Ray Liu
J Trae Hampton
Pairs of split protein segments can modify a variety of target proteins in a living cell.
Sally N Aitken
Sally N Aitken
Genetic variation is inadequate for the adaptation of a montane plant to new climates.
Searching for partners [0.03%]
寻找合作伙伴
Yuwei Zhong,Claude Desplan
Yuwei Zhong
Simplifying a three-dimensional search helps neurons find their targets.
Lora V Hooper,Andrew Y Koh
Lora V Hooper
A metabolite secreted by an intestinal fungus blunts metabolic disease.
New Products [0.03%]
新产品动态
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.