Rohini Pande
Rohini Pande
In January 2025, Donald Trump signed executive orders 14151 and 14173, which were intended to eliminate all diversity, equity, and inclusion (DEI) activities in the federal bureaucracy and nondiscrimination requirements for federal contract...
The cost of health [0.03%]
健康的价格
Lara de Macedo Monteiro
Lara de Macedo Monteiro
Ziyu Xiang,Hongyuan Li,Jianghan Xiao et al.
Ziyu Xiang et al.
Two-dimensional strongly interacting electrons crystalize into a solid phase known as the Wigner crystal at low densities and form a Fermi liquid at high densities. At intermediate densities, the two-dimensional solid evolves into a strongl...
Katheryn B Lefton,Yifan Wu,Yanchao Dai et al.
Katheryn B Lefton et al.
Locus ceruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show t...
Sustainability insights from Late Pleistocene climate change and horse migration patterns [0.03%]
来自晚更新世气候变化和马迁徙模式的可持续性启示
Yvette Running Horse Collin,Clément P Bataille,Samantha Hershauer et al.
Yvette Running Horse Collin et al.
Climate affects habitat, food availability, and the movement and sustainability of all life. In this work, we apply Indigenous and Western scientific methods, including genomics and isotope profiling, on fossils from across Beringia to expl...
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi [0.03%]
两种致病真菌单倍体染色体的独立分离分布规律
Yan Xu,Lei Tian,Jinyi Tan et al.
Yan Xu et al.
Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered that haploid cells of the pathogenic fu...
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase [0.03%]
实验室进化CRISPR相关转座酶在人类细胞中实现程序化基因插入
Isaac P Witte,George D Lampe,Simon Eitzinger et al.
Isaac P Witte et al.
Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISPR-associated transposases (CASTs) cataly...
Leilei Dai,Roger Ruan,Hanwu Lei et al.
Leilei Dai et al.
Precise targeting of HIV broadly neutralizing antibody precursors in humans [0.03%]
在人体中精确靶向广谱中和抗体前体
Tom G Caniels,Madhu Prabhakaran,Gabriel Ozorowski et al.
Tom G Caniels et al.
A protective HIV vaccine will need to induce broadly neutralizing antibodies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging. In a double-blinded, placebo-controlled phase 1 human clinical trial, the recombin...
A wave of Thetis cells imparts tolerance to food antigens early in life [0.03%]
一类Thetis细胞通过早期接触赋予机体对食物抗原的耐受性
Vanja Cabric,Yollanda Franco Parisotto,Tyler Park et al.
Vanja Cabric et al.
Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (APC) that instruct food-specific pTreg c...