Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning [0.03%]
INO80通过大型构象跃迁自抑制调节核小体定位
Upneet Kaur,Hao Wu,Yifan Cheng et al.
Upneet Kaur et al.
Increasing the flanking DNA from 40 to 80 base pairs (bp) causes ~100-fold faster nucleosome sliding by INO80. A prevalent hypothesis posits that the Arp8 module within INO80 enables a ruler-like activity. Using cryogenic electron microscop...
Dome-celled aerogels with ultrahigh-temperature superelasticity over 2273 K [0.03%]
超过2273K的超高温超高弹性穹顶单元气凝胶
Kai Pang,Yuxing Xia,Xiaoting Liu et al.
Kai Pang et al.
Aerogels are known for their high porosity and very low density and can be made from a range of materials, but are limited by structural instability under extreme thermomechanical conditions. We report on 194 types of dome-celled ultralight...
Haunted by sharks [0.03%]
被鲨鱼诅咒
Alexa Robles-Gil
Alexa Robles-Gil
After a series of deadly shark attacks, the Indian Ocean island of Réunion became a hub of shark attack science.
Adam Mann
Adam Mann
World's telescopes scrutinize inbound comet for clues on exoplanet formation.
Elise Cutts
Elise Cutts
Overlooked rock samples from 640 million years ago record microbes clinging to life beneath frozen oceans.
Joseph L Graves Jr,Alan Goodman,Stacy Farina et al.
Joseph L Graves Jr et al.
Arjee J Restar,Kristi E Gamarel,Don Operario
Arjee J Restar
Richard M Allen,Alexei Barski,Micah Berman et al.
Richard M Allen et al.
Earthquake early-warning systems are increasingly being deployed as a strategy to reduce losses in earthquakes, but the regional seismic networks they require do not exist in many earthquake-prone countries. We use the global Android smartp...
Massimo M Onesto,Neal D Amin,Chenjie Pan et al.
Massimo M Onesto et al.
Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led to fundamental discoveries about floor plate (FP)-mediated midline organization, an experimental model of the human...
Kejia Wu,Hanlun Jiang,Derrick R Hicks et al.
Kejia Wu et al.
Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such systems challenging. We describe a general a...