Olga Smirnova
Olga Smirnova
Advanced optical approaches reshape the frontiers of chiral sensing.
Juan Carlos Cambronero-Heinrichs
Juan Carlos Cambronero-Heinrichs
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders [0.03%]
聚甘氨酸介导的FAM98B聚集会干扰GGC重复障碍中的tRNA加工
Jason Yang,Yunhan Xu,David R Ziehr et al.
Jason Yang et al.
Aggregation-prone polyglycine-containing proteins produced from expanded GGC repeats are implicated in an emerging family of neurodegenerative disorders. In this study, we showed that polyglycine itself forms aggregates that incorporate end...
Jinghao Li,Pengcheng Tang,Yang Fan et al.
Jinghao Li et al.
Given the prevalence of nitrogen-containing heterocycles in bioactive molecules, inserting a nitrogen atom into a saturated ring offers a powerful yet underdeveloped scaffold-hopping strategy for expanding drug-like chemical space. In this ...
Mikus Puriņš,Hikaru Nakahara,Mark D Levin
Mikus Puriņš
Pairs of heterocycles differing by a single constitutive ring atom can exhibit stark differences in the retrosynthetic disconnections available for their preparation. Such a synthesis gap is exemplified by pyridine and pyridazine. Pyridine ...
This is not the time to step back from diversity, equity, and inclusion [0.03%]
现在不是放弃多样性、公平性和包容性的时刻
Agustín Fuentes
Agustín Fuentes
Recently, I exchanged views with a prominent Ivy League scientist who was complaining about the minority students and junior faculty applying to his program. He claimed that the university, through diversity, equity, and inclusion (DEI) pol...
Unraveling the emergent chorus of the mind: Machine learning reveals how a hidden neural code orchestrates diverse emotion states [0.03%]
拨开迷雾探寻大脑深处的交响乐：机器学习揭示了隐藏在神经中的编码如何协调多种情绪状态
Aditya Nair
Aditya Nair
Machine learning reveals how a hidden neural code orchestrates diverse emotion states.
Mridu Kapur,Susan L Ackerman
Mridu Kapur
Disruption of transfer RNA processing may unite the pathogenesis of CGG repeat expansion disorders.
Vaccination to mitigate climate-driven disruptions to malaria control in Madagascar [0.03%]
疫苗接种缓解马达加斯加气候驱动的疟疾控制中断事件
Benjamin L Rice,Estelle Raobson,Sylviane Miharisoa et al.
Benjamin L Rice et al.
Extreme weather is common in high malaria burden areas and is likely to increase in severity owing to climate change-related severe weather events. Yet, data on infection rates after these events and the consequences for planning disease co...
Biao Qin,Jianfeng Jiang,Lu Wang et al.
Biao Qin et al.
Two-dimensional (2D) indium selenide, with its low effective mass, high thermal velocity, and exceptional electronic mobility, is a promising semiconductor for surpassing silicon electronics, but grown films have not achieved performance co...