Sensing early civilizations Dinner with King Tut Sam Kean Little, Brown, 2025. 464 pp [0.03%]
触摸早期文明——与图坦卡蒙王共进晚餐萨姆·基安著李明洁译Little, Brown, 2025年464页
Patrick E McGovern
Patrick E McGovern
Armchair archaeologists summon ancient tastes, sights, and sounds to understand the past.
Tianyun Dong,Zhenzhong Zeng,Ming Pan et al.
Tianyun Dong et al.
The year 2023 witnessed an extraordinary surge in marine heatwaves (MHWs) across Earth's oceans, setting new records in duration, extent, and intensity, with MHW activity totaling 53.6 billion °C days square kilometer-more than three stand...
Melanie Mitchell
Melanie Mitchell
A few weeks ago, a colleague of mine needed to collect and format some data from a website, and he asked the latest version of Anthropic's generative AI system, Claude, for help. Claude cheerfully agreed to perform the task, generated a com...
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin [0.03%]
促进RAS与PI3Kα结合的分子胶可以无胰岛素促葡萄糖吸收
Koji Terayama,Shinji Furuzono,Nicole Fer et al.
Koji Terayama et al.
While exploring strategies to control blood glucose concentrations in diabetes, we identified so-called molecular glues D223 and D927 that promote glucose uptake in the absence of insulin. They act by increasing the binding affinity of phos...
Proactive assisted gene flow for Caribbean corals in an era of rapid coral reef decline [0.03%]
珊瑚礁快速衰退时代加勒比珊瑚主动基因流动辅助育种
Andrew C Baker,Iliana B Baums,Sarah W Davies et al.
Andrew C Baker et al.
Regulatory action could facilitate cross-border efforts to retain ecosystem function.
A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors [0.03%]
一个新发多形蛋白界面催化肿瘤中RASG12D天冬氨酸的共价抑制作用
Caroline Weller,G Leslie Burnett,Lingyan Jiang et al.
Caroline Weller et al.
Mutant RAS proteins are among the most prevalent drivers of human cancer, and the glycine to aspartic acid mutation at codon 12 (G12D) is the most common variant. Mutation-selective covalent inhibitors spare RAS in healthy tissue and enable...
Katarzyna Nowak,Jacopo Cerri,Svitlana Kudrenko et al.
Katarzyna Nowak et al.
Running out of road [0.03%]
走投无路
Na Zhao
Na Zhao
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway [0.03%]
一种与SIR2抗噬菌体蛋白同源的人类蛋白质通过 toll 样受体途径介导免疫反应
Delphine Bonhomme,Hugo Vaysset,Eirene Marie Q Ednacot et al.
Delphine Bonhomme et al.
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent information regulator 2 (SIR2) protein dom...