Yichao Zhang,Ballal Ahammed,Sang Hyun Bae et al.
Yichao Zhang et al.
Twisted two-dimensional materials exhibit distinctive vibrational modes called moiré phonons, which arise from the moiré superlattice. Here, we demonstrate atom-by-atom imaging of phasons, an ultrasoft class of moiré phonons in twisted b...
De novo design and structure of a peptide-centric TCR mimic binding module [0.03%]
从头设计并解析一种结合肽类抗原的T细胞受体模体蛋白质结构
Karsten D Householder,Xinyu Xiang,Kevin M Jude et al.
Karsten D Householder et al.
T cell receptor (TCR) mimics offer a promising platform for tumor-specific targeting of peptide-major histocompatibility complex (pMHC) in cancer immunotherapy. In this study, we designed a de novo α-helical TCR mimic (TCRm) specific for t...
De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells [0.03%]
从头设计的pMHC结合物促进T细胞介导的癌症细胞毒性作用
Kristoffer Haurum Johansen,Darian Stephan Wolff,Beatrice Scapolo et al.
Kristoffer Haurum Johansen et al.
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patient material remains complex. We present ...
Bingxu Liu,Nathan F Greenwood,Julia E Bonzanini et al.
Bingxu Liu et al.
Class I major histocompatibility complex (MHC-I) molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance. Proteins that recognize peptide-MHC-I (pMHCI) complexes with specificity for diseas...
Genetics, energetics, and allostery in proteins with randomized cores and surfaces [0.03%]
随机化核心和表面的蛋白质中的遗传学、能量学与别构效应
Albert Escobedo,Gesa Voigt,Andre J Faure et al.
Albert Escobedo et al.
A lack of systematic experimental data limits our understanding of protein evolution. In this study, we experimentally characterized proteins with randomized sequences. Vast numbers of amino acid combinations constitute stable protein cores...
Craig E Landry,Lynne Lewis,Shana McDermott et al.
Craig E Landry et al.
Stone and its stories Strata: Stories from Deep Time Laura Poppick Norton, 2025. 288 pp [0.03%]
石与故事——来自地质年代的故事Laura·波皮克著 Norman出版, 2025. 288页
Riley Black
Riley Black
A journalist pens a love letter to geologic history.
Guangzhou Wang,Wim H van der Putten,John Klironomos et al.
Guangzhou Wang et al.
The challenge of producing food at low monetary cost comes with high environmental impacts as yield maximization by excessive fertilization and chemical pest control drive farmers away from using the natural multifunctional potential of soi...
Little-to-no industrial fishing occurs in fully and highly protected marine areas [0.03%]
几乎没有工业捕鱼发生在完全受保护和高度受保护的海洋区域中
Jennifer Raynor,Sara Orofino,Christopher Costello et al.
Jennifer Raynor et al.
There is a widespread perception that illegal fishing is common in marine protected areas (MPAs) due to strong incentives for poaching and the high cost of monitoring and enforcement. Using artificial intelligence and satellite-based Earth ...
Global patterns and drivers of untracked industrial fishing in coastal marine protected areas [0.03%]
全球沿海海洋保护区内未加监管的渔业模式及驱动因素
Raphael Seguin,Frédéric Le Manach,Rodolphe Devillers et al.
Raphael Seguin et al.
Marine protected areas (MPAs) are expanding worldwide, but industrial fishing within their boundaries remains poorly understood. By combining vessel Global Positioning System data with satellite imagery, we detected industrial fishing in 47...