Imaging collective quantum fluctuations of the structure of a complex molecule [0.03%]
集体量子波动的成像：复杂分子结构的例子
Benoît Richard,Rebecca Boll,Sourav Banerjee et al.
Benoît Richard et al.
Because of the Heisenberg uncertainty principle, the structure of a molecule fluctuates about its mean geometry, even in the ground state. Observing this fundamental quantum effect experimentally-particularly, revealing the collective natur...
Single-photon detection enabled by negative differential conductivity in moiré superlattices [0.03%]
摩尔超晶格中的负微分电导单光子探测
Krystian Nowakowski,Hitesh Agarwal,Sergey Slizovskiy et al.
Krystian Nowakowski et al.
Detecting individual light quanta is essential for quantum information, space exploration, advanced machine vision, and fundamental science. In this work, we introduce a single-photon detection mechanism using highly photosensitive nonequil...
Convergence and divergence of individual immune responses over the life course [0.03%]
个体免疫反应一生中的趋同与分歧
C Jessica E Metcalf,Andrea L Graham,Andrew J Yates et al.
C Jessica E Metcalf et al.
Three ingredients create the strikingly variable immune trajectories observed across human populations: (i) genetic variation, (ii) individual-scale generation of additional genetic diversity solely in lymphocytes, and (iii) collision of th...
Sarah Ross,Caroline Ash
Sarah Ross
Mateo Aboy,Urs Gasser,I Glenn Cohen et al.
Mateo Aboy et al.
Standards offer a flexible, globally harmonized path to govern early-stage quantum technologies while preserving innovation, security, and international cooperation.
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA [0.03%]
转铁蛋白受体靶向抗淀粉样蛋白抗体可增强脑递送并减轻ARIA现象
Michelle E Pizzo,Edward D Plowey,Nathalie Khoury et al.
Michelle E Pizzo et al.
Amyloid-related imaging abnormalities (ARIA), side effects of anti-amyloid drugs seen in magnetic resonance imaging of the brain, are a major safety concern in patients with Alzheimer's disease. We developed an antibody transport vehicle (A...
Radular teeth matrix protein 1 directs iron oxide deposition in chiton teeth [0.03%]
铁oxide在帽贝牙齿中的沉积由牙本质蛋白1调控
Michiko Nemoto,Koki Okada,Haruka Akamine et al.
Michiko Nemoto et al.
Nature builds multiscale mineral structures with impressive mechanical properties through spatially and temporally orchestrated organic-mineral assembly. One example of regulated mineralization is found in hypermineralized and ultrahard mag...
The membrane skeleton is constitutively remodeled in neurons by calcium signaling [0.03%]
钙信号可重构神经元胞膜骨架结构
Evan Heller,Naina Kurup,Xiaowei Zhuang
Evan Heller
The membrane skeleton in neurons adopts a periodic lattice structure in which actin filaments, capped by adducin and tropomodulin, form ring-shaped structures connected by spectrin tetramers along neurites. This membrane-associated periodic...
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice [0.03%]
半胱氨酰白三烯通过促进小鼠食物过敏原的肠道吸收来诱导过敏性休克
Laura R Hoyt,Elise Liu,Eli C Olson et al.
Laura R Hoyt et al.
Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied strains of mice with different sensitivities...