The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD [0.03%]
吸入性皮质类固醇和长效β受体激动剂联合治疗对慢性阻塞性肺疾病预后的影响
Nicola A Hanania
Nicola A Hanania
Chronic obstructive pulmonary disease (COPD) is an under-recognized cause of morbidity and mortality worldwide that imposes an ever increasing burden on the patient and society alike. The disease encompasses multiple structural and function...
Denufosol: a review of studies with inhaled P2Y(2) agonists that led to Phase 3 [0.03%]
吸入性P2Y(2)激动剂的研究进展：登福素引论
Donald Kellerman,Andrea Rossi Mospan,Jean Engels et al.
Donald Kellerman et al.
Among the most promising of the new therapies being developed for the treatment of Cystic Fibrosis (CF) are those targeted at increasing mucosal hydration on the surface of the airways. One of these therapies, P2Y(2) receptor agonists, bypa...
Sildenafil for pulmonary hypertension: dose-dependent improvement in exercise performance [0.03%]
西地那非治疗肺动脉高压：运动能力的改善与剂量相关
Riina Marjaana Spring,Silvia Ulrich,Lars C Huber et al.
Riina Marjaana Spring et al.
Sildenafil has been widely used as an orphan drug for several years, mostly at a dose of 50mg tid. Since a recent randomized study showed no dose-response relationship, the target dose in future will be 20mg tid. This might, however, have a...
Nerve growth factor enhances neurokinin A-induced airway responses and exhaled nitric oxide via a histamine-dependent mechanism [0.03%]
神经生长因子通过依赖组胺的机制增强缓激肽引起的气道反应和呼出的一氧化氮水平
Lydia Bennedich Kahn,Lars E Gustafsson,Caroline Olgart Höglund
Lydia Bennedich Kahn
The neurotrophin nerve growth factor (NGF) is elevated in serum and locally in the lung in asthmatics and has been suggested to evoke airway hyperresponsiveness. The aim of this study was to explore mechanisms behind NGF-evoked changes in a...
Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway [0.03%]
铜绿假单胞菌在囊性纤维化气道中的生物被膜形成过程研究
Sophie Moreau-Marquis,Bruce A Stanton,George A O&#x;Toole
Sophie Moreau-Marquis
The cystic fibrosis (CF) lung is chronically inflamed and infected by Pseudomonas aeruginosa, which is a major cause of morbidity and mortality in this genetic disease. Although aerosolization of Tobramycin into the airway of CF patients im...
Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice [0.03%]
慢性一氧化氮合酶抑制可防止 Caveolin-1 基因敲除小鼠出现不良肺重塑和肺动脉高压
Carsten Wunderlich,Alexander Schmeisser,Christian Heerwagen et al.
Carsten Wunderlich et al.
Recently generated caveolin-1 deficient mice (cav-1 ko) suffer from severe lung fibrosis with marked pulmonary hypertension and arterial hypoxemia and may therefore serve as an useful animal model of this devastating human disorder. Accumul...
Stem cells and cell therapies for cystic fibrosis and other lung diseases [0.03%]
囊性纤维化和其他肺疾病的干细胞和细胞疗法
Daniel J Weiss
Daniel J Weiss
This review will critically evaluate recent findings suggesting that embryonic stem cells and stem cells derived from adult tissues, including bone marrow and umbilical cord blood, may be utilized in repair and regeneration of injured or di...
Randomized comparison of ciclesonide 160 and 640 microg/day in severe asthma [0.03%]
比较两种剂量环索奈德(每日160微克和640微克)治疗重度哮喘的疗效的随机对照试验
E D Bateman,D Cheung,J Lapa e Silva et al.
E D Bateman et al.
Objective: Demonstrating clinical benefit of higher doses of inhaled corticosteroids in asthma is frequently problematic owing to their relatively flat dose-response curve in this condition. In this study we compared the ...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(3):489-98. DOI:10.1016/j.pupt.2007.11.002 2008
GC-MS determined cotinine in an epidemiological study on smoking status at delivery [0.03%]
流行病学调查中使用气相色谱-质谱法测定 delivered 时的 cotinine 含量以确认吸烟状况
Ingrid de Chazeron,Sandrine Daval,Sylvie Ughetto et al.
Ingrid de Chazeron et al.
The objective of this study was to measure the plasma cotinine levels in pregnant women and their newborns using a gas chromatography-mass spectrometry (GC-MS) method in an epidemiological-delivered population with a wide range of tobacco i...
Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease [0.03%]
口服白三烯B4受体拮抗剂LTB019对慢性阻塞性肺疾病患者炎症性痰标志物的影响
L Grönke,K M Beeh,R Cameron et al.
L Grönke et al.
This study aimed to evaluate the effect of a LTB4 receptor antagonist on inflammatory markers in induced sputum, in particular sputum neutrophilia, in ex-smokers with moderate stable chronic obstructive pulmonary disease (COPD). The trial f...
Randomized Controlled Trial
Pulmonary pharmacology & therapeutics. 2008;21(2):409-17. DOI:10.1016/j.pupt.2007.10.007 2008